DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GUCY1A1 and CG43373

DIOPT Version :9

Sequence 1:	NP_000847.2	Gene:	GUCY1A1 / 2982	HGNCID:	4685	Length:	690	Species:	Homo sapiens
Sequence 2:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster

Alignment Length:	855	Identity:	180/855 - (21%)
Similarity:	295/855 - (34%)	Gaps:	271/855 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    19 LLAPGQVPN-ESSEEAAGSSESCKATVPI-----------------CQDIPEKNIQ-ESLPQRKT 64
            ||.||...| |::...:.......|..|:                 |.....||:| |.|.||
  Fly   198 LLQPGDASNLEANNPMSSGGGGGTANGPVSPSISFWFRLNRIILRLCSTHQFKNLQVEMLYQR-- 260

Human    65 SRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKS----LERE----DFEKTIAEQ 121
                 |...:.:|....|......|.:||..||......:.|:|    ||..    |...|:...
  Fly   261 -----YFLRMNQSNTTHILALLLALILALSCTLLVFTTLQLRRSTSLLLEISEIGLDANATVGNL 320

Human   122 AVAAGVPVEVIKE---SLGEEVFKICYEEDENIL--GVVGGTLK--------DFLNSFSTLL--- 170
            ..|...|..:...   :.|..:..:....:.:..  |.|||.||        ||....:..|
  Fly   321 TTATMKPPTLASSDQMTRGSSIPLLALASNGSWAGNGAVGGELKSAHNHNIADFEADHNGQLVWR 385

Human   171 ---------------KQSSH--------------CQEAG--KRGRL-----------EDASILCL 193
                           |..||              .|:||  |.|.:           :||.:..:
  Fly   386 RQKRKHYRRLHKHRYKHKSHQQHRTRYRMREKRSLQDAGLVKGGGIQTQLIVDTATDDDADVYTV 450

Human   194 DKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEV----EVSLMPPCFHNDCSEFVN----- 249
            ..:||             ..:..|....:.|:.|...|    ::|      |.:..|.:|
  Fly   451 ASDDD-------------DDVDGGRSAGSKHITYTPRVRDYNQIS------HAERDEVLNTSSNA 496

Human   250 -------QPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRR 307
                   .|.|.|.    ...|.:.....:|.||....:......:.|:    :.||
  Fly   497 GVATDNSDPPLGYG----QLIPLILMQVDESVLVFLIVMLICGIVYAFL----LCIL-------- 545

Human   308 LMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIY 372
                    .||...|.|.:|   ::....|  |.|.::..|.                      |
  Fly   546 --------SKPAMNEIFLVL---VSYVILG--TFLAIEVAVS----------------------Y 575

Human   373 IVESSAILFLGSPCVD------------RLEDFTGRGLYLSDIPIH-----NALRD--------- 411
            .::.|. .|.||.|..            ||.:....|:.||.:.::     ||::|
  Fly   576 AMQPSK-SFNGSACCIVLIYMTYTMLPLRLREALIGGILLSVVHLYTCLRLNAMQDEAVEMIHWE 639

Human   412 -------VVLIGEQARAQDGLKKRLGKLKATLE-----QAHQALEEEKKKTVDLLCSIFPCEVAQ 464
                   .:|:...........|...:.||.:|     :|....:.|.::...||.|:.|..||.
  Fly   640 ELLCTLVALLLANLTGVYTHWPKEKAQRKAFIETRQCIEARLRTQRENQQQERLLLSVLPRHVAM 704

Human   465 QL----------WQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGE 519
            ::          .|...:..::..||::||:||.|||::..||:..:::.:||.|:.|||:...|
  Fly   705 EMKDDIAGQPRDTQFHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAE 769

Human   520 LDVYKVETIGDAYCVAGGLHKESDTH---AVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGS 581
            ....:::.:||.|....||.:....|   ||::.|..:..:.|..|||:.:   :.||:|:|:|.
  Fly   770 HHCLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVN---VNMRVGIHTGR 831

Human   582 VFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYR------------------LLKD 628
            |..||:|:...::.::.|:|||||..||..:|.:::::..|.:                  .|||
  Fly   832 VHCGVLGLVKWQFDVWSNDVTLANHMESGGIPGRVHITKETLKCLDGDYEVEVGKGNERNSYLKD 896

Human   629 --------CPGFVFTP----RSREELPPNFPSEIPGICHFLDAYQQGTNSKPCF-----QKKDVE 676
                    .||.::.|    |:|.::..|...|:..:.|   ...|...||..|     ..||.|
  Fly   897 HQIETYLIVPGDIYRPHKKSRNRLQVNGNISKELRMMGH---GTAQKHTSKFGFGDSSESAKDPE 958

Human   677 DGNANFLGKA 686
            |....:|.:|
  Fly   959 DEVNEYLMRA 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	39/226 (17%)
GUCY1A1	NP_000847.2	Guanylate_cyc	472..643	CDD:306677	58/203 (29%)
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831	43/244 (18%)
		CYCc	686..881	CDD:214485	58/197 (29%)
		Guanylate_cyc	722..895	CDD:278633	50/175 (29%)
		DUF1053	<949..1005	CDD:283888	6/20 (30%)
		CYCc	1259..1455	CDD:214485
		Guanylate_cyc	1285..1479	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810