Protein Alignment GUCY1A1 and CG32301

DIOPT Version :9

• Sequence 1: NP_000847.2
• Gene: GUCY1A1 / 2982
• HGNCID: 4685
• Length: 690
• Species: Homo sapiens
• Sequence 2: NP_728724.2
• Gene: CG32301 / 38285
• FlyBaseID: FBgn0052301
• Length: 1111
• Species: Drosophila melanogaster
• Alignment Length: 539
• Identity: 108/539 - (20%)
• Similarity: 193/539 - (35%)
• Gaps: 183/539 - (33%)

Human   195 KEDDFLHV--YYFFPKRTTSLILP------------GIIKAAAHVLYETEVEVSLMPPCFHNDCS 245
            |..|||.|  |:.....|.|:::|            .|:.:....|..|.::: ::|.|:.
  Fly    74 KNIDFLTVLPYFAVMLLTPSILMPSREPNVEQYESIAILVSCLMALLLTAMDL-ILPICYF---- 133

Human   246 EFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMN 310
                :|:            ||.||.....:|    |....||..|:
  Fly   134 ----RPF------------SLVPSYDHVVIV----LIYLMFPIAFV------------------- 159

Human   311 RRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVE 375
                   .|...||  |...::..:.|.|.::            :.:....:|.:|.....|
  Fly   160 -------KNGRAYF--LGLAVSLFYFGYMALI------------DKISTLDKVWELTAYGAY--- 200

Human   376 SSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAH 440
               :.||...|           ::||....:| :|..:|...|...|:.:             ..
  Fly   201 ---LFFLNMLC-----------MFLSRFQEYN-MRSGILSRYQVVYQNLV-------------FQ 237

Human   441 QALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQ-------------------AKKFSNVTMLFSD 486
            .|::|||.    ||.||.|..:|:.| |..:..                   .:....|::|.:|
  Fly   238 MAMKEEKA----LLDSIIPVTLARSL-QDAIASHIEEDPSNLMPFTKTRHLFMEPHPEVSILEAD 297

Human   487 IVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIAL 551
            :|.||.:.:......::.:|:.|:..||.........:::.:||:|....|:.....|||.....
  Fly   298 MVDFTGLTTTMEVSDLVAILHELFVSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVN 362

Human   552 MALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKI 616
            .||.|:|:|.||.....:.|.:|||:|||.:.||::|:...::.::..:|.:.|:.||..:|..:
  Fly   363 QALDMIEISREVSKRRNKKIDLRIGVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMV 427

Human   617 NVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNS---KPCFQKK----- 673
            ::|..|..||.:                          |::  |::||::   .|..|:.
  Fly   428 HISSRTLGLLDN--------------------------HYV--YEEGTDTAKLDPLLQRSNLSTY 464

Human   674 -------------DVEDGN 679
                         |:||.|
  Fly   465 LIRSRLPNFEDTDDLEDDN 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	33/188 (18%)
		Guanylate_cyc	472..643	CDD:306677	43/189 (23%)
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	43/155 (28%)
		CYCc	812..1051	CDD:214485
		Nucleotidyl_cyc_III	841..1076	CDD:299850

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900