DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GUCY1A1 and CG3216

DIOPT Version :9

Sequence 1:	NP_000847.2	Gene:	GUCY1A1 / 2982	HGNCID:	4685	Length:	690	Species:	Homo sapiens
Sequence 2:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster

Alignment Length:	250	Identity:	109/250 - (43%)
Similarity:	147/250 - (58%)	Gaps:	12/250 - (4%)

- Green bases have known domain annotations that are detailed below.

Human   404 PIHNALRD---VVLIGEQARAQDGLKKRL----GKLKATLEQAHQALEEEKKKTVDLLCSIFPCE 461
            |..:.:|.   .::.|......|.|..|:    ..|::.:|:..:.|..||::|.:||..|.|..
  Fly   870 PTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRP 934

Human   462 VAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVE 526
            |||||..|.:|:.::||:||:.||||||||.:|::.||:.|:..||.||:.||:..|..||||||
  Fly   935 VAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVYKVE 999

Human   527 TIGDAYCVAGGL-HKESDTHAVQIALMALKMMELSDEVMSPHGEP---IKMRIGLHSGSVFAGVV 587
            ||||||.|..|| ....|.||.:||||||.::.........| :|   |::|||:|||||.||||
  Fly  1000 TIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRH-KPEYKIQIRIGMHSGSVCAGVV 1063

Human   588 GVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREEL 642
            |.|||.|||||:.|..|::.||...|.||:||..|..:|.....|....|...||
  Fly  1064 GKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVEL 1118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	19/68 (28%)
GUCY1A1	NP_000847.2	Guanylate_cyc	472..643	CDD:306677	86/174 (49%)
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368
		ANF_receptor	107..479	CDD:279440
		PKc_like	616..885	CDD:304357	2/14 (14%)
		TyrKc	627..877	CDD:197581	1/6 (17%)
		HNOBA	<882..939	CDD:285003	17/56 (30%)
		CYCc	918..1109	CDD:214485	96/191 (50%)
		Guanylate_cyc	945..1131	CDD:278633	86/174 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810