Protein Alignment GUCY1A1 and CG33958

DIOPT Version :10

• Sequence 1: XP_047306103.1
• Gene: GUCY1A1 / 2982
• HGNCID: 4685
• Length: 767
• Species: Homo sapiens
• Sequence 2: NP_001033958.1
• Gene: CG33958 / 37088
• FlyBaseID: FBgn0053958
• Length: 710
• Species: Drosophila melanogaster
• Alignment Length: 782
• Identity: 194/782 - (24%)
• Similarity: 294/782 - (37%)
• Gaps: 224/782 - (28%)

Human    16 SGQLH-------PAGCGVGKRRVLLHSKSCDRWAAQRRQPANCPAAPRVSYKNYSSSGGDRSRVR 73
            :|:.|       |:.|..|..|:...|...|....|..:|.....||  ...|.|..||
  Fly     3 NGKAHKSGENPDPSPCPAGGSRMPTPSVKIDISTCQSNRPMESRTAP--DDVNPSGEGG------ 59

Human    74 DTNTMFCTKLKDLKITGECPFSLLAPG---------QVPNESSEEAA--GSSESCKATVPICQDI 127
                                 .||.|.         .|.:.|||:.:  ||...|.|..
  Fly    60 ---------------------LLLVPTHHNLQLDKISVRSISSEDISNGGSGRCCNAAA------ 97

Human   128 PEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFE 192
              :|     |..||.| |:.|..:      :|.|....|.:.:|.::...:|.|.|.::...:.:
  Fly    98 --RN-----PAIKTGR-RLQLMQM------IILPFIPILALIVQTSVTLQEILEYRSAVADIETQ 148

Human   193 KTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLK-----DFLNSFSTLLKQS-- 250
            .|||.........:::.:..:...:|....::..|:      ||:     ..||:.:|..:.|
  Fly   149 VTIATDLGKVVTRLQLERSEVAFYIFTNGSKQRANL------TLRFANTDHALNNMTTWSEISVP 207

Human   251 --------------------SHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGI 295
                                |...|...|.|||       .:|.....|..::    || |..|:
  Fly   208 TAPDEDEDDREMMLNRYEFQSRLNEFRDRVRLE-------PEESSITEVMNWY----TS-INRGL 260

Human   296 IKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFC 360
            :...:..:.||:                  |.....|.|..|:...|:.               |
  Fly   261 LHHLSEQIKETD------------------NSGVWRYLVGFKNLLKSIE---------------C 292

Human   361 KTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGK-----PNFEEY--FEILTPK-INQTFSGIMT 417
            :.....|             |||       :.|:     .||..|  :|.:..: ||.|.:....
  Fly   293 QNIATSF-------------GIR-------YYGRGSLTAENFVSYVRYEFMAREMINSTLNYAPM 337

Human   418 MLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDR----LEDFTGRGLYLS 478
            :.||...:      .|.||..|...:          ...|...:|.|..    :|.:.....|..
  Fly   338 LKNMYTNI------TSTKKFHRAKQM----------GTTLLKNNPNVSNERSAIEYYELMNNYTD 386

Human   479 DIPI-HNALR-------DVVLIGEQARAQDGL-----------------KKRLGKLK---ATLEQ 515
            |:.| ..|||       |..|:....:...|:                 |.....::   ..|.|
  Fly   387 DLRILQKALRRLIKEYVDKTLVEADRKEAIGIAILVVVLIVSPVIIVLVKNAAATIQLYALNLSQ 451

Human   516 AHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVI 580
            ..:.|:.||:|:..||..:.|..||.||.|.|.|.|:.:..||:.||||||||.|.:.|:||:|:
  Fly   452 KAKELKREKRKSDSLLFQMLPPSVAMQLKQTQQVPAELYEAVTIYFSDIVGFTEIAADCTPLEVV 516

Human   581 TMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLH-KESDTHAVQIALMALKMMELSDEVMSPH 644
            |.||::|..||::....||||||||||:|.||.||. |..:.|..:||.|||.:::.|.....|.
  Fly   517 TFLNSIYRVFDERIECYDVYKVETIGDSYMVASGLPVKNGNKHISEIATMALDLLDASSVFRIPR 581

Human   645 G--EPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCP 707
            .  |.:::|.|:|:|.|.||:||.|||||||||:.|..|::.||....:||:::...:..|:...
  Fly   582 AGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVG 646

Human   708 GF 709
            ||
  Fly   647 GF 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GUCY1A1	XP_047306103.1	HNOBA	354..543	CDD:462234	44/228 (19%)
		Guanylate_cyc	549..720	CDD:425528	75/164 (46%)
CG33958	NP_001033958.1	NIT	159..396	CDD:462453	54/323 (17%)
		CYCc	459..647	CDD:214485	85/187 (45%)