Protein Alignment GUCY1A1 and ACXC

DIOPT Version :9

• Sequence 1: NP_000847.2
• Gene: GUCY1A1 / 2982
• HGNCID: 4685
• Length: 690
• Species: Homo sapiens
• Sequence 2: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Alignment Length: 480
• Identity: 97/480 - (20%)
• Similarity: 197/480 - (41%)
• Gaps: 109/480 - (22%)

Human   199 FLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTK 263
            ||.:...:.:...::....:|:..:.:|..|.:.:        |.|.:||::...:
  Fly    75 FLTIELLYVQHYNAVFFNFVIRVVSTILVLTVLSI--------NFCEKFVSRHRWV--------- 122

Human   264 PSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILT 328
             .::.|.....||:.|.:...::.|:                     :.|:....:|:.:
  Fly   123 -MIASSVLSVYLVVLTDIVMISYHFY---------------------KNDWPLNTSFDVF----- 160

Human   329 PKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDF 393
                 |...|...|.:..:           |.:.::.....:||:......|...:...||  |.
  Fly   161 -----TLCMIYMFLPIPSI-----------KGAALLASSVSLIYVAFFMHSLTFNAVYTDR--DS 207

Human   394 TGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRL---GKLKATLEQAHQALEEEK-------K 448
            .|..:..:|| :||...:::          |:..|:   ..::|:....||.:.||.       :
  Fly   208 FGYDVISTDI-LHNLGFNMM----------GIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQ 261

Human   449 KTVDLLCSIFPCEVA---QQLWQGQVVQAK----KFS----------------NVTMLFSDIVGF 490
            ::: ||.||.|.::|   |:..:.::.|::    :|.                :|::|::|:|.:
  Fly   262 ESI-LLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNY 325

Human   491 TAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA-YCVAGGLHKESDTHAVQIALMAL 554
            |.:.:..:...::.:|:.||.|||.......|.:::.:||. |||||....:.| ||.....:.:
  Fly   326 THLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPD-HAKCCVSLGI 389

Human   555 KMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVS 619
            .|:....||.:..|..|.||||:||||:.||::|....::.::|.:|.:||..||...|..::||
  Fly   390 SMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVS 454

Human   620 PTTYRLLKDCPGFVFTPRSREELPP 644
            ..|..:|......:.:...:.:..|
  Fly   455 GRTLSMLNPADYTILSGTQKAQSDP 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	33/201 (16%)
		Guanylate_cyc	472..643	CDD:306677	51/191 (27%)
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	45/283 (16%)
		CYCc	293..468	CDD:214485	50/175 (29%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	49/159 (31%)
		CYCc	833..1060	CDD:214485
		Nucleotidyl_cyc_III	861..1085	CDD:299850

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810