DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GUCY1A1 and Gyc32E

DIOPT Version :9

Sequence 1:	NP_000847.2	Gene:	GUCY1A1 / 2982	HGNCID:	4685	Length:	690	Species:	Homo sapiens
Sequence 2:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster

Alignment Length:	619	Identity:	172/619 - (27%)
Similarity:	276/619 - (44%)	Gaps:	137/619 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    90 NVALQR--TLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENIL 152
            |:||.|  .:|..||  .:||::                     |..|:.:|:..:.....|||:
  Fly   575 NIALFRGNIVAMKKI--HKKSVD---------------------ITRSIRKELKLMREVRHENII 616

Human   153 GVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPG 217
            ..:|.:     ....:::..:::|    .||.|||.    |..||  ||:.:.|.....|.||.|
  Fly   617 NFIGAS-----TDHGSVIIFTTYC----ARGSLEDV----LANED--LHLDHMFISSLVSDILKG 666

Human   218 IIKAAAHVLYETEVEVSLMPPCFH-----NDC---SEFVNQ--PYLLYSVHMKSTKPSLSPSKPQ 272
            :|     .|:::|: :|      |     ::|   |.:|.|  .:.|:.:.....:|:.|..:.:
  Fly   667 MI-----YLHDSEI-IS------HGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELK 719

Human   273 SSLVIPTSLFCKTF-PFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNF--EEYFE-ILTPKINQ 333
            .:|.:...|....: |.......|  :..||..:..::.|:...|...:  ||..: :..|::.|
  Fly   720 RALCMAPELLRDAYRPGRGSQKGD--VYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCPEMLQ 782

Human   334 --TFSGIMTMLNMQFVVRVRR-----WDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLE 391
              .|...:|..::.....:|:     ||...:...   |::...:::.|..|.|   .|
  Fly   783 HGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRP---DIRLVRMHLKELQAGL---KP------ 835

Human   392 DFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCS 456
                           |...:::.|         ::|....|:..:::....|.||||||..||..
  Fly   836 ---------------NIFDNMLSI---------MEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQ 876

Human   457 IFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELD 521
            :.|..||:.|.:|..|:|:.|..||:|||||||||.:|:..:|.:|:.|||..||..|......|
  Fly   877 MLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYD 941

Human   522 VYKVETIGDAYCVAGGLHKESDT-HAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVF 583
            |||||||||||.|..||..::.: ||.:||.:||.::|....:...|  .|.:::|||:|||...
  Fly   942 VYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCA 1006

Human   584 AGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLK-------------------DC 629
            |||||.|||||||||:.|..|::.||.....:|::|..||:||:                   |.
  Fly  1007 AGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSIKGKGDM 1071

Human   630 PGFVFTPRSREELPPNFPSEIPGICHFLDAYQQG 663
            ..:..|.|.:.||.|:..|.:    ..||.|..|
  Fly  1072 RTYWLTKRQQPELTPDLISTV----DTLDTYCSG 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	37/199 (19%)
GUCY1A1	NP_000847.2	Guanylate_cyc	472..643	CDD:306677	81/192 (42%)
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365
		ANF_receptor	59..427	CDD:279440
		PHA02988	534..826	CDD:165291	62/305 (20%)
		PK_GC-A_B	550..832	CDD:270944	63/311 (20%)
		HNOBA	<847..886	CDD:285003	14/38 (37%)
		CYCc	865..1057	CDD:214485	90/191 (47%)
		Guanylate_cyc	892..1076	CDD:278633	78/183 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810