DRSC/TRiP Functional Genomics Resources

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Protein Alignment GUCY1A1 and rut

DIOPT Version :10

Sequence 1:XP_047306103.1 Gene:GUCY1A1 / 2982 HGNCID:4685 Length:767 Species:Homo sapiens
Sequence 2:NP_511156.2 Gene:rut / 32406 FlyBaseID:FBgn0003301 Length:2248 Species:Drosophila melanogaster


Alignment Length:232 Identity:73/232 - (31%)
Similarity:121/232 - (52%) Gaps:27/232 - (11%)


- Green bases have known domain annotations that are detailed below.


Human   489 VVLIG------------EQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQ 541
            |:.||            |:|:.:..|..| ..:.:.||     :::|.:|...||.|:.|..||.
  Fly   191 VIFIGVNVAGLVVNIMMERAQRRTFLDTR-NCIASRLE-----IQDENEKLERLLLSVLPQHVAM 249

Human   542 QLWQ-------GQV--VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGEL 597
            |:..       ||.  :..:|..||::||:||||||.:.||||..:::.:||.|:.||||...:.
  Fly   250 QMKNDILSPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDN 314

Human   598 DVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAG 662
            ...:::.:||.|....||.:....||.....|.|.|::....|:......:.||:|:|:|.|..|
  Fly   315 HCLRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCG 379

Human   663 VVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTT 699
            |:|::..::.::.|:|||||..||...|.:::|:..|
  Fly   380 VLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRAT 416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GUCY1A1XP_047306103.1 HNOBA 354..543 CDD:462234 17/65 (26%)
Guanylate_cyc 549..720 CDD:425528 53/151 (35%)
rutNP_511156.2 AC_N <17..255 CDD:318454 18/69 (26%)
Guanylate_cyc 266..428 CDD:425528 53/151 (35%)
Adcy_cons_dom 624..698 CDD:461877
AcyC 742..1150 CDD:441717
Guanylate_cyc 954..1151 CDD:425528
Blue background indicates that the domain is not in the aligned region.

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