DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GUCY1A1 and CG32305

DIOPT Version :9

Sequence 1:	NP_000847.2	Gene:	GUCY1A1 / 2982	HGNCID:	4685	Length:	690	Species:	Homo sapiens
Sequence 2:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster

Alignment Length:	244	Identity:	70/244 - (28%)
Similarity:	118/244 - (48%)	Gaps:	34/244 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   448 KKTVDLLCSIFPCEVAQQLWQGQVV-----QAKKFS---------------NVTMLFSDIVGFTA 492
            ||...||.||.|.::.:.| |.::.     |.|.|:               ||::|.:|:|.:|.
  Fly   246 KKENGLLESILPRKMIRTL-QEEICSRIEDQDKNFTPSKAGLRKLFLEPYPNVSILVADMVNYTH 309

Human   493 ICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAY-CVAGGLHKESDTHAVQIALMALKM 556
            :.:.....|::.:|:.|:..||.........:::.:||:| ||| |:......||......||:|
  Fly   310 LTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVA-GIPNYFPAHASCCVDQALEM 373

Human   557 MELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPT 621
            :.::..|.|.....|.:|||:|||.||||::|....::.::..:|.:.|:.||..:|..::||..
  Fly   374 IHITQGVSSRRELDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQR 438

Human   622 TYRLLKDCPGFVFTPRSREELPPNFP-SEIPGICHFL------DAYQQG 663
            |..:|.:  .::|  |...|...|.| .:..||..||      ||.:.|
  Fly   439 TLSMLDE--HYIF--REGTEAAKNDPILQQAGIRTFLVSNRLPDAVEPG 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	7/17 (41%)
GUCY1A1	NP_000847.2	Guanylate_cyc	472..643	CDD:306677	52/191 (27%)
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	56/201 (28%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	46/153 (30%)
		CYCc	814..1056	CDD:214485
		Nucleotidyl_cyc_III	845..1081	CDD:299850
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810