DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bag3 and Nedd4

DIOPT Version :9

Sequence 1:	NP_038891.4	Gene:	Bag3 / 29810	MGIID:	1352493	Length:	577	Species:	Mus musculus
Sequence 2:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster

Alignment Length:	395	Identity:	88/395 - (22%)
Similarity:	134/395 - (33%)	Gaps:	96/395 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse    22 DPLPPGWEIKIDPQTGWPFFVDHNSRTTTWNDPRVPPEGPKDTASSANGPSRDGSRLLPI-REGH 85
            |.||.|||.:.| ..|..::|:|.:|||.|:.|.|        .:|.:..|.|....... |..|
  Fly   246 DALPAGWEERQD-ANGRTYYVNHTARTTQWDRPTV--------LNSHSSQSTDDQLASDFQRRFH 301

Mouse    86 PIYPQLRPGYIPIPVLHEGSENRQPHLFHAYSQPGVQRFRTEAAAATPQRSQSPLRGGMTE-AAQ 149
            ........|.....:.|...|:.......||:.      :|.|.::.|..:.:...|.:.: |.|
  Fly   302 ISVDDTESGRSADSISHNSIEDNNNAAGLAYTP------KTAATSSAPPNTPTNNNGILAQIAMQ 360

Mouse   150 TDKQCGQMPATATTA----AAQPPTAH-GPERSQSPAASDCSSSSSSASLPSSG------RSSLG 203
            ...:..|.|....|:    :.:.|.|| .||.|.:...:|......:..:|...      |.:.|
  Fly   361 YRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNPFTRRAAG 425

Mouse   204 SHQLPRGYIPIPVIHEQNITRPAAQPSFHQAQKTHYPAQQG------EYQPQQPVYHKIQGDDWE 262
            :.....|:       :|...|...|....|.|:.....||.      :::.|:| .|:.|....:
  Fly   426 NMAGGAGW-------QQERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEP-QHRGQRHQQQ 482

Mouse   263 PRPLRAASPFRSPVRGASSREGSPARSGTPVHCPSPIRVHTVVDRPQPMTHREP-------PPVT 320
            .||               |.|.:   ..|..|.||.|..        |.|.|..       ||:.
  Fly   483 HRP---------------SNEDT---DHTDSHNPSDISA--------PSTRRNSEEDNAAVPPME 521

Mouse   321 QPENKPESKPGPAGPDLPPGHIPIQVI------------RREADSKPVS-QKSPPPAEKVEVKVS 372
            | ....|.:|      ||| ...:||.            ||.....|.: :.||.|.:...|:..
  Fly   522 Q-NTGGEEEP------LPP-RWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDD 578

Mouse   373 SAPIP 377
            ..|:|
  Fly   579 LGPLP 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bag3	NP_038891.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81		19/58 (33%)
		WW	23..55	CDD:197736	13/31 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..207		19/92 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..427		39/175 (22%)
		BAG	426..503	CDD:214591
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..577
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809	13/29 (45%)
		WW	531..560	CDD:278809	7/29 (24%)
		WW	581..613	CDD:197736	2/3 (67%)
		HECTc	650..1003	CDD:238033
		HECTc	674..1003	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11382
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900