DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZDHHC1 and Zdhhc8

DIOPT Version :9

Sequence 1:	NP_037436.1	Gene:	ZDHHC1 / 29800	HGNCID:	17916	Length:	485	Species:	Homo sapiens
Sequence 2:	NP_001259382.1	Gene:	Zdhhc8 / 31887	FlyBaseID:	FBgn0085478	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	246	Identity:	67/246 - (27%)
Similarity:	100/246 - (40%)	Gaps:	63/246 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    55 AWLLYLFFAVIGFGILVP----LLPHHWVPAGYACMGAIFAGHLVVHLTAVSIDPA-------DA 108
            ||::.|....:.|  ..|    :..|.||   .|..|.|....|.....|..:||.       |.
  Fly    16 AWIVLLLTTFLFF--FYPCQFYVKSHPWV---LAYQGVITFFVLANFTLATFMDPGIIPKASPDE 75

Human   109 NVRDKSYAGPLPIFNRSQ-HAHVIEDLHCNLCNVDVSARSKHCSACNKCVCGFDHHCKWLNNCVG 172
            :..::..|   |::..:: :...::...|..|......|..|||.||.|:..|||||.|:|||:|
  Fly    76 DCEEELRA---PLYKNAEINGITVKMKWCVTCKFYRPPRCSHCSVCNHCIETFDHHCPWVNNCIG 137

Human   173 ERNYR---LFLHSVASALLGVLLLVLVATYVFVEFFVNPMRLRTNRHFEVLKNHTDVWFVFLPAA 234
            .||||   .||.|::..:|.:..|.||  ||                .:::.|..|       .|
  Fly   138 RRNYRFFFFFLVSLSIHMLSIFSLCLV--YV----------------LKIMPNIKD-------TA 177

Human   235 PVETQAPAILALAALLILLGL---LSTALLGHLLCFHIYLMWHKLTTYEYI 282
            |:           ..:||:||   |:..:.| |..||:.|:....||.|.:
  Fly   178 PI-----------VAIILMGLVTILAIPIFG-LTGFHMVLVSRGRTTNEQV 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZDHHC1	NP_037436.1	Mediates interaction with STING1. /evidence=ECO:0000269\|PubMed:25299331	1..271		63/233 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		zf-DHHC	129..284	CDD:307600	49/160 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..358
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..485
Zdhhc8	NP_001259382.1	zf-DHHC	94..219	CDD:279823	49/160 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810