DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GUCY1A2 and Gyc89Da

DIOPT Version :9

Sequence 1:	NP_001243353.1	Gene:	GUCY1A2 / 2977	HGNCID:	4684	Length:	763	Species:	Homo sapiens
Sequence 2:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster

Alignment Length:	686	Identity:	160/686 - (23%)
Similarity:	295/686 - (43%)	Gaps:	160/686 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   109 LKRTLQYYEHQVIGYRDAEKNFHNISNRC---SYADHSNKEE--IEDVSGILQ-CTANILGLKFE 167
            |..::|:|..:..|.....|..|.|.  |   |:..|....:  :.|::..|. ||    |..|:
  Fly     5 LYESVQHYVQEEYGVDIWRKVCHIID--CKHNSFKTHQIYPDKLMPDIAEALSACT----GESFD 63

Human   168 EIQKRFGEEFFNICFHEN---ERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKE 229
            .....||..|  :.|..|   ::::|:.|....||....|.:...:|.::.|   ::|||.....
  Fly    64 FCMNFFGRCF--VRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLIMRFTYPK---MKSPSMQLTN 123

Human   230 LPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKLCSDVSNPGNC-------S 287
            :.:...::.|......:...::|.:....::.|.|:::...:.::   :|:|. |..       .
  Fly   124 MDDNGAVILYRSSRTGMSKYLIGQMTEVAREFYGLEIKAYVIESQ---NDISG-GTAGPIKLTDG 184

Human   288 CLTFLIK---ECENTNIM-KNLPQGTSQVPADLR---ISINTFCRAFPFHLMFDPSMSVLQLGE- 344
            .||.::|   :.:|...| |.:  .|...|:.|:   :.::.|...|||..:.:..|.:...||
  Fly   185 PLTVIVKYRLDFDNREYMAKRV--NTEAHPSQLKMPTVKLDVFLDLFPFTFVLNHDMKITHAGEK 247

Human   345 ----------GLRKQLRCDTHKVLKFEDC----------------------FEIVSPKVN-ATFE 376
                      |...:....|| |:....|                      ||::....| |.::
  Fly   248 IVETWIMHNPGANPKSFIGTH-VMDLFQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYD 311

Human   377 RVL-----------LRLSTPFVIRTKPEASGSENKD-----------------------KVMEVK 407
            .||           |..:....:....|.|.|...|                       :.:.:|
  Fly   312 AVLNMDFENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEIDPATGERRSSQGLRSILLK 376

Human   408 GQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQ--AKAQDGLKK--- 467
            |||.::.:.:|::||.||.::.||||.|.||:|:|:..|..:|::::.|.|  :|.:...:|
  Fly   377 GQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQ 441

Human   468 RMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIV---- 528
            |.|:|:.:||    ..:..|::..:||||:.|..:|:::...::...:.|::|:::|.:::
  Fly   442 RSDELEKSLE----LADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYD 502

Human   529 -GFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALM 592
             |..:|..   .||.::.||::::..|.:.....:|||||:|..|...:|....:..||:....:
  Fly   503 EGLNSIQG---AMQTVNTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDL 564

Human   593 ALKMMELSEEVLTPDGRPIQPQRSELLFSFPVSIQLVPDQHQSETDLGTEKMRIGIHSGSVLAGV 657
            ||::|:..:                              .|    |:|...:|:||:||.|:|||
  Fly   565 ALRVMKKFK------------------------------AH----DMGDVAIRVGINSGPVVAGV 595

Human   658 VGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTT 693
            ||.::|||||||:.|..||:.||.|.|.:|.:|..|
  Fly   596 VGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYT 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GUCY1A2	NP_001243353.1	HNOB	<159..270	CDD:285002	21/113 (19%)
		HNOBA	316..503	CDD:285003	59/262 (23%)
		CYCc	485..705	CDD:214485	61/214 (29%)
		Guanylate_cyc	514..729	CDD:278633	54/185 (29%)
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	35/166 (21%)
		HNOBA	218..476	CDD:285003	59/262 (23%)
		CYCc	457..643	CDD:214485	61/212 (29%)
		Guanylate_cyc	485..662	CDD:278633	54/184 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820