DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment USP25 and Usp47

DIOPT Version :9

Sequence 1:	NP_001269970.1	Gene:	USP25 / 29761	HGNCID:	12624	Length:	1125	Species:	Homo sapiens
Sequence 2:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster

Alignment Length:	828	Identity:	186/828 - (22%)
Similarity:	292/828 - (35%)	Gaps:	246/828 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    75 PGNDRYISVGSQADTNVIDLTG-DDKDDLQRAIALSLAESNRAFRETGITDEEQAISRVLEASIA 138
            ||.|.....|   |::|..:|| .|...:........|.||...|:.| .||.:|..||......
  Fly   312 PGYDYGAPTG---DSDVEGVTGVTDPSTIGTDDGTYPALSNFYRRKYG-GDELRAWQRVNTTGAD 372

Human   139 ENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPP 203
            ...:....|..|..:.|..|       :..|||.|...||:.::::|:||...|||..:..::..
  Fly   373 FVSSATTETEAEARQASLGP-------RGYVGLVNQAMTCYLNSLLQALFMTPEFRNALYRWEFD 430

Human   204 SNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEI--LKDAFKSNDS---QQQDV 263
                    |..|.:|:|:  :|:.||..|      ...|..|||.  |..:|..:.:   ||.|:
  Fly   431 --------NDNEAKNIPY--QLQKLFLNL------QTSPKAAVETTDLTRSFGWDSTEAWQQHDI 479

Human   264 SEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAVGVLEGKKFE-------NTE--- 318
            .|....:.|.||..|:        ..|..|.:..|:          |||..:       |||
  Fly   480 QELCRVMFDALEHKFK--------NTKQANLISNLY----------EGKMNDYVKCLECNTEKTR 526

Human   319 --MFGQYPLQV------NGFKDLHECLEAAM----IEGEIESLHSENSGKSGQEH---WFTELPP 368
              .|...||.|      :.:..:.|.|.|.:    ::|..:.| .|...|....|   .|...|.
  Fly   527 EDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQYL-CEKCKKKCDAHKGLHFKSFPY 590

Human   369 VLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRL 433
            :||..|.||:|:.......|:::::.|||.|.|:.:::|
  Fly   591 ILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINR-------------------------- 629

Human   434 ERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDASSPPSGSIPSQTLPSTTEQQGALS 498
                |..||.:...|                 ...||  |.|:..|||         ..:...||
  Fly   630 ----SGNSGEQNSQL-----------------NGTVD--DCSTADSGS---------AMEDDNLS 662

Human   499 SELPSTSPSSVAAISSRSVIHKPFTQSRIPPDLPMHPAPRHITEEELSVLESCLHRWRTEIENDT 563
            |.:.:|:.||                             :|                    |||.
  Fly   663 SGVVTTASSS-----------------------------QH--------------------ENDL 678

Human   564 RDLQESISRIHRTIELMYSDKSMIQ----VPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYN 624
            .|..|.|.....|      .||..|    ..|.|.|:::|.|.|:.|||:|||.|...:.|..:|
  Fly   679 NDEDEGIDMSSST------SKSAKQGSGPYLYELFAIMIHSGSASGGHYYAYIKDFDNNEWFCFN 737

Human   625 DIAVTKSSWEELVRDSFGG-----YRNA-----SAYCLMY--INDKAQFLIQE--EFNKETGQPL 675
            |..||..:.|::.| ||||     |.:|     :||.|||  ::.|...|:.:  :|.:.
  Fly   738 DQNVTSITQEDIQR-SFGGPNGSYYSSAYTSSTNAYMLMYRQVDAKRNELVAKVADFPEH----- 796

Human   676 VGIETLPPDLRDFVEEDNQRFEKELEEWDAQLAQKALQEKLLASQKLRESE-TSVTTAQAAGDPE 739
              |:||.|.|....|....|..:.:...|..|...........:..|::.: |.|..:|:
  Fly   797 --IKTLLPKLHSEEETRVSRLGRHITVTDLALPDLYKPRVYFYNPSLKKMKITRVYVSQS----- 854

Human   740 YLEQPSRSDFS---------KHLKEETIQIITKASHEHEDKSPETVLQSKPENTTSQPLSNQRVV 795
                     |:         :.|..|....:::......:.|.:|::||. |:.|...|:..|..
  Fly   855 ---------FNINLVLMSAYEMLNVEQFAPLSRCRLVAYNSSMDTIIQSL-ESCTDPALTELRAA 909

Human   796 EVAIPHVGKFMIESKEGGYDDEIMMTPNMQGIIMAIGKSRSVYDRCGP 843
            :   .:...|::|.:....:.|:.....:...:..:..|....|  ||
  Fly   910 Q---NYSLDFLLEYRAEDQEFEVYPPNGITWYVFKVDLSTMAMD--GP 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
USP25	NP_001269970.1	UBA_UBP25	15..60	CDD:270539
		SUMO interaction domain (SIM)	77..102		7/25 (28%)
		Required for SUMO paralog-specific binding	89..95		1/5 (20%)
		UCH	168..>405	CDD:278850	69/266 (26%)
		Peptidase_C19I	170..655	CDD:239130	128/530 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..507		11/42 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	727..749		3/21 (14%)
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188
		Rib_recp_KP_reg	122..265	CDD:282899
		peptidase_C19C	394..780	CDD:239124	129/534 (24%)
		UCH	395..776	CDD:278850	127/529 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810