DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hdac11 and HDAC11

DIOPT Version :9

Sequence 1:	NP_001100080.2	Gene:	Hdac11 / 297453	RGDID:	1311706	Length:	347	Species:	Rattus norvegicus
Sequence 2:	NP_001247296.1	Gene:	HDAC11 / 326120	FlyBaseID:	FBgn0051119	Length:	343	Species:	Drosophila melanogaster

Alignment Length:	310	Identity:	167/310 - (53%)
Similarity:	212/310 - (68%)	Gaps:	1/310 - (0%)

- Green bases have known domain annotations that are detailed below.

  Rat    17 PIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLN 81
            |||:|..|.:.|.|||:||||||.|...:...|..:..|.||...|..|.:::.|..:|||.||.
  Fly    33 PIVFSRNYAVRFGGLERLHPFDAAKGKHIHKLLCAQLQLDDGSFYEPTELTKDQLRRIHTREYLK 97

  Rat    82 ELKWSFVVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSS 146
            .|:||..||.|.|:|.:.|:||..:||..|||:|.|..|:|:|||||::.|||||:|||||||.|
  Fly    98 SLRWSMNVACIAEVPLMAFVPNRYIQRSYLRPMRFQAAGSILAGKLALDYGWAINLGGGFHHCCS 162

  Rat   147 DRGGGFCAYADITLAIKFLFERVE-GISRATIIDLDAHQGNGHERDFMGDKRVYIMDVYNRHIYP 210
            .||||||.||||:|.|..|||:.. .:.|..|:||||||||||||||.....|||.|:||..:||
  Fly   163 YRGGGFCPYADISLLIVRLFEQEPFRVRRIMIVDLDAHQGNGHERDFNNVAAVYIFDMYNAFVYP 227

  Rat   211 GDRFAKEAIRRKVELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSISP 275
            .|..|||:||..|||...|||..||.:::|.:.:||.|..||:|||||||||||||.||.|:||.
  Fly   228 RDHVAKESIRCAVELRNYTEDGFYLRQLKRCLMQSLAEFRPDMVVYNAGTDVLEGDPLGNLAISA 292

  Rat   276 AGIVKRDEVVFRVVRAHDIPILMVTSGGYQKRTARIIADSILNLHDLGLI 325
            .|:::||.:||...||..||::|:.||||.|.:|.:|.|||:||...||:
  Fly   293 EGVIERDRLVFSTFRALGIPVVMLLSGGYLKASAGVITDSIVNLRLQGLL 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hdac11	NP_001100080.2	HDAC_classIV	35..319	CDD:212519	153/284 (54%)
HDAC11	NP_001247296.1	HDAC_classIV	51..336	CDD:212519	153/284 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352802
Domainoid	1	1.000	295	1.000	Domainoid score	I1438
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11743
Inparanoid	1	1.050	325	1.000	Inparanoid score	I2399
OMA	1	1.010	-	-		QHG57761
OrthoDB	1	1.010	-	-		D1037375at2759
OrthoFinder	1	1.000	-	-		FOG0006007
OrthoInspector	1	1.000	-	-		oto97087
orthoMCL	1	0.900	-	-		OOG6_103672
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4306
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770