DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema4f and Sema1b

DIOPT Version :9

Sequence 1:	NP_062145.1	Gene:	Sema4f / 29745	RGDID:	3658	Length:	776	Species:	Rattus norvegicus
Sequence 2:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster

Alignment Length:	802	Identity:	215/802 - (26%)
Similarity:	343/802 - (42%)	Gaps:	174/802 - (21%)

- Green bases have known domain annotations that are detailed below.

  Rat    23 PLSLLLLLAILSAPVCGRVPRSVPRTSLPISEADSYLTRFAASHTYNYSALLVDPASHTLYVGAR 87
            |:.||:.|:.|:. |.|.:|...|...   ::.|..|..|..:.| :|..:| |.....:.|||:
  Fly    18 PMILLITLSGLTI-VAGWMPDVKPDLQ---TKQDKVLAHFIGNST-DYFKIL-DHNDEFVLVGAK 76

  Rat    88 DSIFALTLPFSG-ERPRRIDWMVPETHRQNCRKKGKKEDECHNFIQILAIVNASHLLTCGTFAFD 151
            |.|:.::|  :| :...|::|...:..|:.|..|||.|.:|||::::.|:.....:|.|||.::.
  Fly    77 DVIYNVSL--NGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGEVLLCGTNSYK 139

  Rat   152 PKC---GVIDVSSFQ------------QVERLESGRGKCPFEPAQRSAAVMAGGVLYTATVKNFL 201
            |:|   ..::|||.:            :|.|....:|.||:.||..|....|.|.||:|||.:|.
  Fly   140 PRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFS 204

  Rat   202 GTEPIISRAVGRAEDWIRTETLS-SWLNAPAFVAAMVLSPAEWGDEDGDDEIFFFFTETSRVLDS 265
            |.:|:|.|      :.:|||... ..||.|.||.|:          :.:..:.|||.|.|..:.:
  Fly   205 GGDPLIYR------ENLRTEQYDLKQLNQPDFVGAI----------ERNGYVLFFFRELSMEVMN 253

  Rat   266 YERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASGVLQAMAELRPQPGAGT-P 329
            :.:....||||||..|.||..:..:.||:||||.|.|..|  |........:..:.|...:|: .
  Fly   254 FGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVP--GEFPFYFDEIQAISPIVESGSKS 316

  Rat   330 IFYGIFSSQWEGAAISAVCAFRPQDIRAVLNGPFRELKHDCNRGLPVMDNEVPQPRPGECIANNM 394
            :.|.:|::.......||||||...||.|..:|.|:..|...:..|||...:||:||||:|:.:
  Fly   317 LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCVED-- 379

  Rat   395 KLQQFGSSLSLPDRVLTFIRDHPLMDRPVFPADGRPLLVTTDTAY--LRVVAH-RVTSLSGKEYD 456
                   |.:|....:.||::||||:..|....|||||...:..:  ..:..| :|.||||..||
  Fly   380 -------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAYYD 437

  Rat   457 VLYLGTEDGHLHRAVRIGAQLS-------------VLEDLALFPEPQPVESMKL--YHDWLLVGS 506
            |:|.||:||.:.:.:.|   ||             |:.::.:.|...|:..:.:  ..:.|:|.|
  Fly   438 VIYSGTDDGKVTKFINI---LSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKNSLVVVS 499

  Rat   507 HTEVTQVNTSNCGRLQSCSECILAQDPVCAWSFRLDACVAHA-GEH----RGMVQDIESADVSS- 565
            ...:..|...:|..:..|..|:..|||:|||..:...|...| .:|    :..:|.:.|...::
  Fly   500 DGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQSLNSTKKAAA 564

  Rat   566 -LCPKEPGEHPVVFEVPVATVGHVVLPCSPS-------SAWASCVWHQPS-----------GVTA 611
             |||..|.:.|     ...||..|.:...|:       |...|...:|||           |:..
  Fly   565 LLCPHIPRDAP-----GAETVSFVTMAPPPTEEQKLLYSNVGSSQGNQPSLEQQPTGGDDFGLNK 624

  Rat   612 LT---------------PRR-----DGLEVVVTPGAM------------GAYACECQEGGAARVV 644
            :|               |::     |.::...||..|            |..|..|       .|
  Fly   625 ITLTSMDPDDIMPNLNDPQKSTASVDEIKYASTPSFMLLTTIVFFTFLVGGIAGIC-------CV 682

  Rat   645 AAYSLVWGSQRGPSNRAHTVVGAGLVGFLLGVLAASLTLLLIGRRQQRRRQRELLARDKVGLDLG 709
            .|.|.:..:|...|:|.|                       .|:..|.:.|       ..|.|:.
  Fly   683 KAKSRLMEAQMDESHRNH-----------------------FGKPMQFKHQ-------NTGKDIN 717

  Rat   710 APPSGTTSYSQDPPSPSPEDER 731
            . ..|:.:|:....:|:.:.|:
  Fly   718 L-LMGSNAYTTTQKTPNLDLEK 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema4f	NP_062145.1	Sema_4F	57..516	CDD:200522	151/494 (31%)
		PSI	517..568	CDD:279745	15/57 (26%)
		Ig	575..654	CDD:299845	23/128 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	702..741		6/30 (20%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q9Z123	774..776
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	149/489 (30%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	9/26 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910