DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema6c and Sema1b

DIOPT Version :9

Sequence 1:	NP_059004.1	Gene:	Sema6c / 29744	RGDID:	3659	Length:	960	Species:	Rattus norvegicus
Sequence 2:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster

Alignment Length:	756	Identity:	232/756 - (30%)
Similarity:	330/756 - (43%)	Gaps:	178/756 - (23%)

- Green bases have known domain annotations that are detailed below.

  Rat     6 HSMPLLLLLLLSLPQAQTAFPQDPIPLLTSDLQGTSPSSWFRGLEDDAVAAELG--LDFQRFLTL 68
            :::|::||:.||.......:..|..|    |||..         :|..:|..:|  .|:.:.|..
  Fly    15 NAIPMILLITLSGLTIVAGWMPDVKP----DLQTK---------QDKVLAHFIGNSTDYFKILDH 66

  Rat    69 N-RTLLVAARDHVFSFDLQAQEEGEGLVPNKFLTWRS--QDMENCAVRGKLTDECYNYIRVLVPW 130
            | ..:||.|:|.:::..|      .||.....|.|.|  .|.|.||::||...:|:||:||....
  Fly    67 NDEFVLVGAKDVIYNVSL------NGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYALR 125

  Rat   131 DSQTLLACGTNSFSPVCRSYGITSLQQEGEE-----------------LSGQARCPFDATQSTVA 178
            .:..:|.|||||:.|.||.|  |.::...||                 :..|..||:....::..
  Fly   126 PNGEVLLCGTNSYKPRCRHY--TPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTY 188

  Rat   179 ISAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVYALEHGDHVYFFFREVS 243
            ..|:|.|||||.|||...|.::||.     .||:.:||.|.|.:|.||.|:|...:|.|||||:|
  Fly   189 AFADGHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELS 248

  Rat   244 VEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQSLTGPVNL 308
            :|....|:..:||||||||.|.|| |.:..:.||||||.||||||||:..||||.:|:::..|..
  Fly   249 MEVMNFGKAVYSRVARVCKNDRGG-PYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVES 312

  Rat   309 HGRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSCA 373
            ..:|.::.||||..|:|||||||||.:|||...|:|:||.|:.....|.||..::||.||||.|.
  Fly   313 GSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCV 377

  Rat   374 GVGAAALFSSSQDLPDDVLLFIKAHPLLDPAVPPATHQPLLT-------LTSRALLTQVAVDGMA 431
                    ..|:.|....:.|||.|||::.|||....:||||       ||:.|:..|  |..::
  Fly   378 --------EDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQ--VKSLS 432

  Rat   432 GPHRNTTVLFLGSNDGTVLKVLPPGGQSLGPEP---------IILEEIDAYSHARCSGKRSPRAA 487
            |.:.:  |::.|::||.|.|.:    ..|...|         :::.|:....           ..
  Fly   433 GAYYD--VIYSGTDDGKVTKFI----NILSTHPNSTVDRLKTVVISEMQVLP-----------LG 480

  Rat   488 RRIIGLELDTEGHRLFVAFPGCIVYLSLSRCARHGACQRSCLASLDPYCGW-------------- 538
            ..|..|.:.|..:.|.|...|.:|.:.|..|:....| ..||:..||.|.|
  Fly   481 TPIRELVISTSKNSLVVVSDGSLVSVPLHHCSHIVDC-LGCLSLQDPICAWDLQTHECKNLATSQ 544

  Rat   539 HRFRG-----------------CVNI--RGPGGTDVDLT---------------------GNQES 563
            |:|..                 |.:|  ..||...|...                     |||.|
  Fly   545 HKFGTKTYLQSLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSNVGSSQGNQPS 609

  Rat   564 MEHGDCQDGATGSQSGPGDSAYVLLGPGPSPETPSSPSDAHPG---PQSSTLGAHTQGVRRDLSP 625
            :|          .|...||.    .|......|...|.|..|.   ||.||  |....::...:|
  Fly   610 LE----------QQPTGGDD----FGLNKITLTSMDPDDIMPNLNDPQKST--ASVDEIKYASTP 658

  Rat   626 ASASRSIPIPLLLACVAAAFALGASVSGLLVSCACRRANRR 666
            :       ..||...|...|.:| .::|:    .|.:|..|
  Fly   659 S-------FMLLTTIVFFTFLVG-GIAGI----CCVKAKSR 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema6c	NP_059004.1	Sema	52..516	CDD:417757	177/501 (35%)
		PSI	517..>538	CDD:396154	7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..624		19/92 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..725
		PHA03307	730..>956	CDD:223039
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	745..792
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	806..960
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	177/496 (36%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1206
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2014
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8939
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.820