DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc22a5 and CG6356

DIOPT Version :9

Sequence 1:	NP_062142.1	Gene:	Slc22a5 / 29726	RGDID:	3702	Length:	557	Species:	Rattus norvegicus
Sequence 2:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	143/533 - (26%)
Similarity:	235/533 - (44%)	Gaps:	28/533 - (5%)

- Green bases have known domain annotations that are detailed below.

  Rat    11 LGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHR-CLVP--HTVNLSSAWRNHSIPLETK 72
            :|..|.|...||||.....|.|||:..|...|...|:.: |.:|  ...|.:.|.:...:.....
  Fly    31 VGSGGAFVWAIFFLCVTPNILNGFHVSSYTLLGHLPDDQWCGIPELQDTNWTHAQKREIVAKGLD 95

  Rat    73 DGRQVPQSCRRYRLATIANFSALGLEPGRDVDLEQLEQENCLDGWEYNKDVFLSTIVTEWDLVCK 137
            .|...........||.::..:||.. .|....:....:.:|....::......:|.|.:|||.|.
  Fly    96 SGGCTVWDWNYGHLAKMSYEAALNY-TGHLTQISPPAEVSCRVKGQHEFAHPETTFVADWDLTCD 159

  Rat   138 DDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGFSFLQLFSVNFEMFTVLFVL 202
            ...:.........:|...|||..|.|:|:||||:...|........||...||..:.:|......
  Fly   160 RSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIVGSFFCTFSPWYSLFLAGRFA 224

  Rat   203 VGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRDWRMLLLALTVPG 267
            :|......:..||.:..|.:....| .:.::.....|..|.::|.:..|.|:.||.|.||||:|.
  Fly   225 LGAASSGLFYPAFTMIVENICLKHR-SWMSIAFSASYPVGMIILAIVGYVIQPWRHLQLALTIPS 288

  Rat   268 VLCGALWWFIPESPRWLISQGRVKEA-EVIIRKAAKFN---GIVAPSTIFDPSELQDLNSKKPQS 328
            :|.....:.:.|||||||:..|.... :::.|:.:.:.   .:.|||.:     ..|..|.:|:.
  Fly   289 LLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPAVAAPSQV-----ASDKKSLEPEE 348

  Rat   329 -------------HHIYDLVRTRNIRIITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLA 380
                         ..|.:|.....:|.:...|..::...|:.|:..:|:..||....|:......
  Fly   349 GFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSLSYYVTALNAANLSVSRYLYIIGTG 413

  Rat   381 AVEVPAYVLAWLLLQHLPRRYSISAALFLGGSVLLFIQLVPSELFYLSTALVMVGKFGITSAYSM 445
            .|::|:|::..::|:...||.:........|..||.:..||:.......|..|:|:|||::.||:
  Fly   414 LVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVPAGSTTWIVAFAMLGRFGISATYSV 478

  Rat   446 VYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFV-YLGAYDRFLPYILMGSLTILTAILTLFF 509
            |.:||||||||.:||..:|..||.:.:|||.:||.| .|||...::|..:.|...::..:|||..
  Fly   479 VTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWYIPTTICGCCVLVAGLLTLTL 543

  Rat   510 PESFGAPLPDTID 522
            ||:....|.|.::
  Fly   544 PETGTGKLSDKVE 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a5	NP_062142.1	2A0119	12..520	CDD:273328	142/528 (27%)
		MFS	123..510	CDD:119392	114/404 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..557
CG6356	NP_651240.1	MFS	167..544	CDD:119392	108/382 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347264
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.940