DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc22a5 and CG4630

DIOPT Version :9

Sequence 1:	NP_062142.1	Gene:	Slc22a5 / 29726	RGDID:	3702	Length:	557	Species:	Rattus norvegicus
Sequence 2:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	579	Identity:	185/579 - (31%)
Similarity:	311/579 - (53%)	Gaps:	70/579 - (12%)

- Green bases have known domain annotations that are detailed below.

  Rat     3 DYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLSSA-----W 62
            |:|::...:||:|.|||..:.|:...::....|.:|.||.||:|.:||.||....|..|     |
  Fly    14 DFDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANW 78

  Rat    63 RNHSIPLE-TKDGRQVPQSCRRYRLATIANFSAL--GLEPGRDVDLEQ-------LEQENCLDGW 117
            .:.::|.. :|.|...|.:|.|:    :||...|  ..:|.....|:|       .|.|.|
  Fly    79 VSIAVPGSWSKRGHFTPSTCERF----VANGDHLESSSDPWSAWPLDQCFAENFTTETERC---- 135

  Rat   118 EYNKDVFLS---TIVTEWDLVCKDD-WKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNV-LFLTM 177
              |:.|:.|   |||.:|.|.|.:: ||.....::.|.|:::|:.:||.|:||:|||:: ||..:
  Fly   136 --NQFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIV 198

  Rat   178 GMQ-TGFSFLQLFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAF 241
            .|. ||.:  |..|.::..|....:|..:|....|..||::|.|::....|.: :::.:..|||.
  Fly   199 FMALTGVA--QALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREM-SSIVLNYFYAV 260

  Rat   242 GFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRVKEAEVIIRKAAKFNGI 306
            |..:|.| :.|:.|||.|.|||:||.::|.|.:|.:|||.|||:::.|.::|.||||:|||.|..
  Fly   261 GEALLGL-SVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRR 324

  Rat   307 VAPSTIFDPSELQDLNSKKPQSHH----------------IYDLVRTRNIRIITIMSIILWLTIS 355
            .....:....:.|:|:::..|...                :.::.|:..:.....:.:::|...:
  Fly   325 DISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNA 389

  Rat   356 VGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQHLPRRYSISAALFLGGSVLL---FI 417
            :.|:||||:..:|.|:.|:|..|:..||:|.|.||||.|:...||.::|.:|.|.....:   |:
  Fly   390 IVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFV 454

  Rat   418 QLVPSELF----------------YLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVS 466
            .|...:..                :|...|.:|||.||||:::::|.:|||:.|||:|:.||||.
  Fly   455 TLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVM 519

  Rat   467 STASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFFPESFGAPLPDTIDQML 525
            ||.:|.|::|:|:...|.:|...||.:|.|:|:::..:|:|..||:|...||||:::.:
  Fly   520 STFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEAI 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a5	NP_062142.1	2A0119	12..520	CDD:273328	181/563 (32%)
		MFS	123..510	CDD:119392	139/427 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..557
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	181/563 (32%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	122/378 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.880