DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc22a5 and CarT

DIOPT Version :9

Sequence 1:	NP_062142.1	Gene:	Slc22a5 / 29726	RGDID:	3702	Length:	557	Species:	Rattus norvegicus
Sequence 2:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	178/569 - (31%)
Similarity:	283/569 - (49%)	Gaps:	27/569 - (4%)

- Green bases have known domain annotations that are detailed below.

  Rat     3 DYDEVTAFLGEWGPFQRLIFF-LLSASIIPNGFNGMSIVFLAGTP-EHRCLVPHTVNLSSAWRNH 65
            |.|::...:||:|.:|:|:.| :...:.||.||...:.:|:|.|| ::.|.:|..::|....|..
  Fly    35 DLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLDLPLEQRKS 99

  Rat    66 -SIPLETKDGRQVPQSCRRYRLATIANFSALGLEPGRDVDLEQLEQE------NCLDGWEYNKDV 123
             |||.|..:...|...|..|.:    |::.| ||.|.:.||..:|..      .|..|||||..|
  Fly   100 LSIPKELDNDELVYSKCYTYGV----NWTQL-LESGEEDDLTTMEPNASWPLIKCPQGWEYNTSV 159

  Rat   124 FLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGFSFLQL 188
            ..|:||.::||||..|....:..:....|..:|.::.|.|:||.||:...|:.:......|.:..
  Fly   160 VWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLLAGSLMTS 224

  Rat   189 FSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFI 253
            .|.:|..:....|:||:...:.|...|::..|::.::.| .|.|:..|.||..|.|:|....|..
  Fly   225 LSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYR-SFVTVMTCTFYTSGIMLLSGVTYLE 288

  Rat   254 RDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRVKEAEVIIRKAAKFNGIVAPSTIFDPSEL 318
            |||..|....::|........:.:|||||||:.:||::||..|:.:.||.||...|..:....|.
  Fly   289 RDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVHLKLEA 353

  Rat   319 Q------DLNSKKPQSHHIYDLVRTRNIRIITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCF 377
            |      ....||..:..:.||.||.|:|:.||:..:.|......|.|||...|.|..:.||:.|
  Fly   354 QIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALGTNQYVSFF 418

  Rat   378 LLAAVEVPAYVLAWLLLQHLPRRYSISAALFLGGSVLLFIQLVPSELFYLSTALVMVGKFGITSA 442
            |.|.||:|:|:..|..:....||:.:|.::.|||...:...::|.:....:..|.:|.|..::::
  Fly   419 LSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLYLVSKALLSAS 483

  Rat   443 YSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTL 507
            :.::|.:..|||||.||.:|:|.||....||.|..|:..|||..:..||.::||.|::|..:..|
  Fly   484 FLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGL 548

  Rat   508 FFPESFGAPLPDTIDQMLRVKGIKQWQIQSQTRTQKDGGESPTVLKSTA 556
            ..||:....||.||::.....  |.||.:...|.    .:.|.:|...|
  Fly   549 RLPETLHHRLPQTIEEGEEFG--KNWQFKDCCRC----AQKPEILSQPA 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a5	NP_062142.1	2A0119	12..520	CDD:273328	167/522 (32%)
		MFS	123..510	CDD:119392	124/392 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..557		4/20 (20%)
CarT	NP_610052.1	2A0119	44..561	CDD:273328	167/522 (32%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	115/369 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9198
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D375160at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.930