DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hivep2 and shn

DIOPT Version :9

Sequence 1:NP_077051.1 Gene:Hivep2 / 29721 RGDID:61988 Length:2437 Species:Rattus norvegicus
Sequence 2:NP_001260883.1 Gene:shn / 36171 FlyBaseID:FBgn0003396 Length:2587 Species:Drosophila melanogaster


Alignment Length:2625 Identity:543/2625 - (20%)
Similarity:873/2625 - (33%) Gaps:860/2625 - (32%)


- Green bases have known domain annotations that are detailed below.


  Rat    65 GSGKLASPGEGVHQVTEKQYPPHRPSPYPCQHSLSFPQHS-LPQG--MMHSNKPHQSLEGPPWLF 126
            |.|.|.:.|:.|           |.:......|||.|..: |..|  :|...:.||.::......
  Fly   323 GGGALQASGDAV-----------RTTSLSSNSSLSPPPTTPLANGHHLMTQQQSHQQVQQQQQQQ 376

  Rat   127 SGPLPSVASEDL---FPFPMH----GH------SSGY-----PRKKISSLNPAYSQYSQKSIEQA 173
            ..|.||||..:.   |....|    ||      :|||     .|..:::.|...:..|..:...|
  Fly   377 QTPPPSVAIHEFSANFVNSNHVNAIGHEESIISNSGYKAAGRTRTPLANSNSNTNSTSNSNSNHA 441

  Rat   174 EDA---------HKKEHKP------------------KKPGKYICPYCSRACAKPSVLKKHIRSH 211
            .:|         |::..:|                  :|.|:|:|.||:..|||||||:||||:|
  Fly   442 ANATLSPASFAQHQQLTQPTTVSPGIPGGAAAPNPACEKSGRYVCQYCNLICAKPSVLEKHIRAH 506

  Rat   212 TGERPYPCIPCGFSFKTKSNLYKHRKSHAHAIKA-GL-VPFTESSVSKLDLEAGFIDVEAEIHSD 274
            |.||||||..||.:||||||||||.:|.:||.:| || ||        .|.:.|..|.:||:.:.
  Fly   507 TNERPYPCDTCGIAFKTKSNLYKHCRSRSHAARARGLEVP--------ADADDGLSDQDAELSNS 563

  Rat   275 GEQSTDTDEESSLFAEASDKVSPGPPIPLDIASRGGYPGSLEESLGGPMKVPILIIPKSGIPLPN 339
            ..                           ::.||.|.|  .||.:..|...|        ..|..
  Fly   564 SS---------------------------ELPSRAGSP--YEEPINSPTPSP--------STLSA 591

  Rat   340 EGSQYLGPDMLPNPSLNAKADDSHTVKQKLALRLSEKKGQDSEPSLNLLSPHSKGSTDSGYFSRS 404
            ..|.|:....||            |..|:|.|         ..|:...|.|    :|...:.|.:
  Fly   592 AKSAYIQQPPLP------------TYMQQLPL---------GSPAAGTLPP----TTADNHHSAT 631

  Rat   405 ESAEQQI-----SPPNTNAKSYEEIIFGKYC---RLSPRNTLSVTPTGQERTAMGRRGLVEPLPH 461
            ....|.|     .|...||..|.       |   .|..:.........|::..:.::.|...||.
  Fly   632 AQHRQSIDYKPYKPKFHNASLYS-------CSSKELQQQQQQLQIQQQQQQHQLAQQKLSIQLPL 689

  Rat   462 VNTRLEVKMFEDPITQLIPSKGEMDPSQVNMLKTTKFNSECRQPQAMAASVRNEGKPYPGSFPGS 526
            |...........|.||: ..|..::..|:.:        :.:|.|::.|                
  Fly   690 VQQPSLAHPTLSPSTQM-KMKHHINSHQIQL--------QLQQQQSLLA---------------- 729

  Rat   527 NPILLEAPVDSSPLIRSNSMPTSSATNLSIPPSLRGSHSFDERMTGSDDVFYPGTVGIPPQRMLR 591
            ...||.|            ||......|       |..|:..:.|.:         .|....:..
  Fly   730 QQSLLAA------------MPPGGVYYL-------GQPSYYNQDTAA---------AIHQHALAI 766

  Rat   592 RQAAFELPSVQEGHMEFEHPARVPKILAGSSLKEKKLVPGDRSGYDYDACRKPYKKWEDPETPKQ 656
            :|....|...|:...: :||   |.:.|...:::...:|                       |:|
  Fly   767 QQFQIHLAQQQQQQQQ-QHP---PLVKATPPMQQPPSLP-----------------------PQQ 804

  Rat   657 SYR---DISCLSTFKHGGEYFMDPSVPLPGVPTMFGTTCENRKRRKEKSVGDEEDTPMICGGMGS 718
            ..|   .||.::|         .|:.|.|..         |.......|.|.:.:...:      
  Fly   805 LVRANSQISSVAT---------APATPTPAA---------NLSTFASSSGGKQVNVAKV------ 845

  Rat   719 APGSMMSSEYDSKLQDGGRSGFTMTGHESLPHGYSDRLDLARPQLPSRSPSLGSEDLPSAGDPDK 783
                   .|:.|||         ::.:|::.......|....|:..|||.|..:.:..:|..   
  Fly   846 -------QEHISKL---------ISQNEAIVENKEILLQKKYPKQLSRSRSFNNANSNNASQ--- 891

  Rat   784 MTDLGKKPPGNVISVIQHTNSLSRPNSF--ERSESTEMAVSTQDKTPSPSEMGDSEVLEGPVSPE 846
                    .|:..|.:...||.:..|:.  ||.....:|.:...|.....:....:.:       
  Fly   892 --------HGSNASALHANNSQNNTNAQMPERETKVNLAQAIFQKQQHQLQQQQQQQI------- 941

  Rat   847 WAPPGDGAESGSRPTPSQQVPQHSYH---GQPRLVRQHNIQVPEIRVTEEPDKPEKEKEAPTKEP 908
                        .....||:.|.:|:   .|.:..:|..::.|...|.....||......|.|:.
  Fly   942 ------------TQQQQQQLEQQNYYTYIQQQQECQQQQLEPPNGVVKRNAYKPGVVMTTPVKQQ 994

  Rat   909 EK--------PVEEFQW---PQRSETLSQLPAEKLP------PKKKRLRLADMEHSSGESSFEST 956
            ::        |::..|:   |....|..:.|...:|      ..|.:..|..:..||..:|    
  Fly   995 QQLPPPPSPLPMQTMQYRQDPATPVTKIEQPTTAVPVMPLNLSAKPKPTLVTVPVSSLSTS---- 1055

  Rat   957 GTGLSRSPSQESNLSHSSSFSMSFDRDETVKLTAPPKQDESGK-------HSEFLTVPAGS---- 1010
              .|:.:|:..:|.:.||.             ||||....:..       ::..|.||.|.    
  Fly  1056 --SLAPTPTTSTNPTSSSK-------------TAPPPAQVNNSIIKNLLLNARGLAVPIGEGDDA 1105

  Rat  1011 -YSLSVPGHHHQKEMRRCSSEQMPCPHPTEVPEIRSKSFDYGNLSHAPVAGASPSTLSPSRERKK 1074
             ||..:           |:||.    ...:..::.:.::.....|.||::.||    ||.|..  
  Fly  1106 VYSCPI-----------CASEF----RSADDLKLHNSTYCQDASSSAPMSPAS----SPFRSN-- 1149

  Rat  1075 CFLVRQASFSGS-PEIAQGEAGMDPSVKQEQLEQLHAGLRAAWTTVLPPLPGDDPGKQVVGPCGQ 1138
                   |.|.| ||:....|                                            
  Fly  1150 -------SISLSLPELKSHMA-------------------------------------------- 1163

  Rat  1139 LSSGPPLHLAQQQIMHMDSQESLRNPLIQPTSYMTGKHLPEQPHLFPHQDAVPFSPIQNALFQFQ 1203
             :|..||.||:   :.....::.|:.|:  .|.::....|.:............:|.        
  Fly  1164 -NSKNPLSLAK---LAWSQLKTKRSSLV--LSRLSAAQTPARTSTVTAPTVTASAPA-------- 1214

  Rat  1204 YPTVCMVHLPAQQP-PWWQA-HFPHPFTPHPQNSYSKPPFQADIHSSYSLEHVAEHTGKKSAD-- 1264
             |.|..|..|:..| |..:| .|.....|.|.....|.|.         :::..:.|.:|:.|  
  Fly  1215 -PAVATVTAPSSAPAPQIEALRFVDAPLPSPGPLLGKTPL---------VDYAQQSTPRKAQDSV 1269

  Rat  1265 ---------------YPHAKEQTYPCYSGASGLHSKNLPPKFPSDPGSKST---EAPPTEQLLRE 1311
                           .|..:.:|......:|.....:....|.:...|.|.   ::...|:|.|.
  Fly  1270 VITKMHEDRQFVIEAQPAKRIKTSDLVVASSSQQPTSFNFSFNNQNSSNSVPELQSSKEERLRRF 1334

  Rat  1312 DFASENAGPLQSLPG-TVVPVRIQTHVPSYGSVMYTSISQILGQNSPAIVICKVDENMTQRTLVT 1375
            ..:..:..|:...|. ...|..|:|.:.|.||....|:.          |..:...:..:|.|: 
  Fly  1335 TSSGGSMIPISECPDLDNSPKMIRTPLLSGGSFQDVSVK----------VNNETGSSSKERKLM- 1388

  Rat  1376 NAAMQGIGFNIAQVLGQRTGLEKYPLWKVPQTLPL-GLESSIPLCLPSTSDSAASLGGSKR---- 1435
             |.:.|.|     :||..:|.:.:      |..|: .:.:..||.||..|      ||.|.    
  Fly  1389 -ALVSGSG-----LLGVSSGPQHF------QFPPINSITAFNPLTLPPMS------GGDKTTPVT 1435

  Rat  1436 -------MLSPAS---SLELFMETKQQKRVKEEKMYGQIVEELSAVELTNSDIKKGLSRPQKPQL 1490
                   |..|.|   .:.|.....||.::......|                 :..:|.|...|
  Fly  1436 PIPHVPGMPGPGSLTPQMPLLPPPPQQLQLPIPSSRG-----------------RSPNRKQPSPL 1483

  Rat  1491 VRQGCASEPKD----GSSQSRSSSFSSLSPSSSQDHPAASGPFPPNREIL--SGSRAPPRRKF-- 1547
            :..|.:.|.|.    |..|:..|.||...|:            |..|:.|  :...||.:..|  
  Fly  1484 LLGGGSGELKALSPFGGVQNVPSEFSRQPPT------------PAQRQALQWNSKEAPKKAPFNF 1536

  Rat  1548 --------SGPSESRESSDELDIDETSSDMSMSPQSSSLPTGGSQQED--------EGKARKL-P 1595
                    :...|.|..:.|..|.....::.::|.....|.|.:.:|.        ..|::.| |
  Fly  1537 LRMADNVKTTEPEVRHFNLENVISGKQQELPLTPLHVDTPNGNAPEETSPVASASASAKSKFLRP 1601

  Rat  1596 VSMLV---------HMASGPGGNVANSTLLFT------DVADFQQILQ-----FPSLRTTTTVSW 1640
            .|:.:         |....|   .||:..|.:      ..:..|..|.     :..|:.:|.:.:
  Fly  1602 TSLPLKPGTFTPKRHHGITP---TANTLPLISPETPRPSKSCVQLYLNGHAYTYLGLKCSTKMFY 1663

  Rat  1641 CFLNYTKPNFVQQATFKSSVYASWCISSCN-PNPSGLNTKTTLALLRSKQKITAEIYTLAAMHRP 1704
            |.:|..:|::| ....|.|:|:.|.:...| |:|.|...|..:||..|:|::.....:.|   ..
  Fly  1664 CTVNCPQPSYV-AGMHKLSMYSVWQVCEENQPHPLGFKLKQVMALYDSRQRMLGNGSSTA---MA 1724

  Rat  1705 GTGKL-----------------TSSSAWKQFAQMKPDAPFLFGNKLERKLGGNVLKERGKGEIHG 1752
            |:|||                 ::|||:.|.....|....:           ..|.|        
  Fly  1725 GSGKLSYNLVASQQIVSSPSTSSTSSAFYQGPLKTPPTVTI-----------AALSE-------- 1770

  Rat  1753 DKDLGSKQTEPIRIKIFE---------GGYKSNEDYVYVRGRGRGKYICEECGIRCKKPSMLKKH 1808
             .::.:|..|..:.|..|         |||:|:|||.|:||||||:|:|.|||||||||||||||
  Fly  1771 -ANVAAKANEEAQAKKLETSPSGQPLVGGYESHEDYTYIRGRGRGRYVCSECGIRCKKPSMLKKH 1834

  Rat  1809 IRTHTDVRPYVCKLCNFAFKTKGNLTKHMKSKAHMKKCLELGVSMTSVDETETEEAENME-DLHK 1872
            |||||||||:.|..|||:|||||||||||:||.|.|||:|||::...:    ..::|.:: |:..
  Fly  1835 IRTHTDVRPFTCSHCNFSFKTKGNLTKHMQSKTHFKKCIELGINPGPM----PPDSEFLDVDMDF 1895

  Rat  1873 TSEKHSMSGISTDHQFSDAEESDGEDGDDNDEDDEDDDDFDDQGDLTPKTRSRSTSPQPPRFSSL 1937
            ..:..:.:|..|.   |.|.|||.:|..||:.:..|.|:          ::||....:..|    
  Fly  1896 DQQSSTSAGGRTS---SMAGESDSDDYSDNESESSDTDE----------SKSRQKEHEAAR---- 1943

  Rat  1938 PVNVGAVAHGVPSDSSLGHSSLISYLVTLPSIQVTQLMTPSDSCEDTQMTEYQRLFQSKSTDSEP 2002
                                .|:|..:|.|   :.|.::|....:||.:..........|:.|:|
  Fly  1944 --------------------GLLSLSMTPP---IPQSVSPYPQLQDTPLPAASPANSIGSSGSQP 1985

  Rat  2003 DKDRLDIPSSMDEEAMLSSEPSSSPRDFSPSSYRSSPGYDSSPCRDNSPKRYLIPKGDLSPRRHL 2067
            .:             ::.|..|..|    |..|:....|.|:| .::.|||.:            
  Fly  1986 KR-------------LVCSFTSPKP----PFDYQKQEQYYSNP-EESKPKRSV------------ 2020

  Rat  2068 SPRRDLSPMRHLSPRKEAALRREMSQGDASPRRHLSPRRPLSPGKDITTRRDLSPRRERRYMTTI 2132
             ...:.:||....||....|                                             
  Fly  2021 -ANEESAPMDLTKPRGSILL--------------------------------------------- 2039

  Rat  2133 RAPSPRRALYHNPPLPMGQYLQTEPIVLGPPNLRRGLPQV-----PYFSLYGDQEGAYEHHGSSL 2192
            .:|||.....|:  ||..|..|...::.|......|..:.     ....:..:.|...:|..   
  Fly  2040 ISPSPVSVPAHD--LPKSQAQQMHDVIFGTSGNESGFMKTLISVSDKVRISAEMEEQAKHEA--- 2099

  Rat  2193 FPEGPTDYVFSHLPLHSQQQVR-----------------APIPMVPVGGIQMVHSLPPAISGLHP 2240
              ||....:.:::..|:..|.:                 |..|::.........:..|.:| ::.
  Fly  2100 --EGEDVQLQTYIKEHALHQAKIKQSQFSRSYLINTLYTAASPVMSSSSTLFTANSRPVMS-VNE 2161

  Rat  2241 PPTLPL----PTEGSEEKKGAPGEA---LTQ------------DPYTLSRRHEKQAPHVLQSSGL 2286
            .|::.:    ..|..|..:.||.:|   |.|            :|:..:.....|.|.|.:.:|:
  Fly  2162 VPSIEVHEVKTPEAIESPRSAPEQAPVILAQIAQEENEEPNIAEPHNANLPAAVQQPDVNEFTGV 2226

  Rat  2287 PSSPSSPRLLMKQSTS-----------EDSLNSTEREQ------EENIQTCTKAIASLRI----- 2329
            ..:|::|......:||           ..:.|||:..|      |:..::.|....|..:     
  Fly  2227 LGNPTAPPTSSVTATSVSTTTAAPVAPSSTANSTQPAQRTVIVGEDGFKSSTPTSKSGDLQHVSY 2291

  Rat  2330 --ATEEAALLGADQPTWV------QESPQKPLESAHISIRHFSGPEPGQLCT----SAAHPDLHD 2382
              ....|.:.|..:||..      |...|..|   |::|.:.......:.|:    :..|...|:
  Fly  2292 GRGVPPAPIAGDARPTCTMCSKTFQRQHQLTL---HMNIHYMERKFKCEPCSISFRTQGHLQKHE 2353

  Rat  2383 GEK---------DTFGTSQTAVAHP 2398
            ..:         .|||...|:...|
  Fly  2354 RSEAHKNKVMMTSTFGVPTTSNPRP 2378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hivep2NP_077051.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..121 15/58 (26%)
C2H2 Zn finger 191..211 CDD:275368 14/19 (74%)
zf-H2C2_2 204..228 CDD:290200 16/23 (70%)
C2H2 Zn finger 219..239 CDD:275368 13/19 (68%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 271..304 0/32 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 340..416 16/80 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 717..1002 53/313 (17%)
Nuclear localization signal. /evidence=ECO:0000255 934..940 1/5 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1284..1305 3/23 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1480..1591 26/134 (19%)
zf-C2H2 1790..1812 CDD:278523 19/21 (90%)
C2H2 Zn finger 1792..1812 CDD:275370 18/19 (95%)
zf-H2C2_2 1804..1829 CDD:290200 19/24 (79%)
C2H2 Zn finger 1820..1838 CDD:275370 14/17 (82%)
C2H2 Zn finger 1843..1877 CDD:275371 8/34 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1938 17/83 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1993..2125 19/131 (15%)
10 X 4 AA tandem repeats of S-P-[RGMKC]-[RK] 2044..2139 12/94 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2233..2316 24/118 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2364..2437 8/48 (17%)
shnNP_001260883.1 C2H2 Zn finger 486..506 CDD:275368 14/19 (74%)
zf-H2C2_2 499..523 CDD:290200 16/23 (70%)
C2H2 Zn finger 514..536 CDD:275368 14/21 (67%)
zf-C2H2 1816..1838 CDD:278523 19/21 (90%)
C2H2 Zn finger 1818..1838 CDD:275370 18/19 (95%)
zf-H2C2_2 1830..1855 CDD:290200 19/24 (79%)
zf-C2H2 1844..1868 CDD:278523 17/23 (74%)
C2H2 Zn finger 1846..1868 CDD:275370 17/21 (81%)
zf-C2H2 2307..2328 CDD:278523 5/23 (22%)
C2H2 Zn finger 2308..2328 CDD:275368 4/22 (18%)
zf-C2H2_jaz 2333..2359 CDD:288983 3/25 (12%)
C2H2 Zn finger 2336..2358 CDD:275368 3/21 (14%)
C2H2 Zn finger 2381..2403 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 107 1.000 Domainoid score I6377
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 319 1.000 Inparanoid score I2452
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm45702
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45944
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
77.110

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