DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kcnj2 and Irk3

DIOPT Version :9

Sequence 1:	NP_058992.1	Gene:	Kcnj2 / 29712	RGDID:	61968	Length:	427	Species:	Rattus norvegicus
Sequence 2:	NP_001137835.2	Gene:	Irk3 / 35131	FlyBaseID:	FBgn0032706	Length:	446	Species:	Drosophila melanogaster

Alignment Length:	352	Identity:	111/352 - (31%)
Similarity:	194/352 - (55%)	Gaps:	18/352 - (5%)

- Green bases have known domain annotations that are detailed below.

  Rat    22 ATMAVANGFGNG--KSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWM 84
            :|:.:....|:|  .|.....::..:|.::|:|..||.|..:.||..||:.|:.||.:::.|::|
  Fly    91 STIELTPDLGSGPRTSSSDGLRRSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYM 155

  Rat    85 LVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKES--------KACVSEVNSFTAAFLFSIETQT 141
            |.:|..::.||||.|..:.:::|..|||......|        ..|:..|:|:.|..::|:||||
  Fly   156 LTLFLGSYFLSWLLFAALCYVVAYSHGDFIFDPVSGKRMGEGVDPCIYGVHSWVAMIIYSVETQT 220

  Rat   142 TIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDG 206
            |:|:|.:..::|||..:|:.|.|.:...:|:..::..:.||.|:|.::...|.||..|||..|||
  Fly   221 TLGFGEKYASEECPETIFLFVMQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDG 285

  Rat   207 KLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVH 271
            :|||::||.:.|:...:|:.:|..::..:.|.|||.|. ..:::.:   .|.....::.|..:.|
  Fly   286 RLCLLFRVCDPREQQSIESKIRVYIIVDKRTREGETIK-SHVELKL---EGNGEQIILWPDVVCH 346

  Rat   272 EIDEDSPLYDLSKQDIDN-ADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLF--EE 333
            .|||.|||...:...:.| |.||:.|.:.|...|||..|:.::|||..||.||.|:..::.  .:
  Fly   347 VIDETSPLSQFTTAKLFNAAQFELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNIIHYDAQ 411

  Rat   334 KHCYKVDYSRFHKTYEVPNTPLCSARD 360
            ...|.|||..|::|..| :.|:.:.::
  Fly   412 NERYIVDYENFNRTISV-DMPMTNPKN 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kcnj2	NP_058992.1	IRK_N	1..47	CDD:400662	4/26 (15%)
		IRK	48..186	CDD:395797	48/145 (33%)
		Selectivity filter. /evidence=ECO:0000250	142..147		2/4 (50%)
		IRK_C	193..366	CDD:407551	57/171 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..427
		PDZ-binding. /evidence=ECO:0000255	425..427
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	105/317 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020