DRSC/TRiP Functional Genomics Resources

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Protein Alignment Scn8a and NaCP60E

DIOPT Version :9

Sequence 1:NP_062139.2 Gene:Scn8a / 29710 RGDID:3638 Length:1978 Species:Rattus norvegicus
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:2653 Identity:822/2653 - (30%)
Similarity:1172/2653 - (44%) Gaps:863/2653 - (32%)


- Green bases have known domain annotations that are detailed below.


  Rat    53 PKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLN---RGKTLFRFSATPALYI 114
            |:..:.:|.|..||..:...|:.:...|||:.|. ::.::||.|::   |...:.||:.|.:|::
  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFL 108

  Rat   115 LSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPEWSKNVEYTFTGIYTFESLVKIIA 179
            ..|::..||:.:.|..:..|...:|.|||.||:|:..:   |..:..||.|..||:.|.::||||
  Fly   109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIA 170

  Rat   180 RGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 244
            :||.::.:|:||:|||||||.||...|.|..:::||::.||||||||||||:|::||||||:.||
  Fly   171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235

  Rat   245 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCV-----VWPINFNESYLENGTRGFDWEE 304
            :.|.::|::||.||:|||.||||..||::||.||||||     .|.   |.|:.       ||:.
  Fly   236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWT---NVSHT-------DWQI 290

  Rat   305 YINNKTNFYMVPGMLEPLLCGNSSDAGQCPEGFQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQ 369
            ::|:..|:......| |:||||.:.|..||..:.|:..|.|||:|||:||.|.|:.|..|:|:|.
  Fly   291 WVNDTDNWLYDEDEL-PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITL 354

  Rat   370 DYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAE------QK 428
            |||||:|.:.|...|...:.||.:|:|.|||||:||:|||||::|||:.:.|.||.:      :.
  Fly   355 DYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRD 419

  Rat   429 EAEF---------KAMLEQLKKQQEEAQAAAMA-----------TSAGTVSEDAIEEEGEDGVGS 473
            ::.|         |.:.:..||:.:..:...:|           |..|       :|.|.:|.|:
  Fly   420 DSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGG-------KEGGTNGNGN 477

  Rat   474 PRSSSELSKLSS---------KSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAF 529
            ..:..:....|:         .||.||.:....:.||:..:.|::   .|:.||.| .|......
  Fly   478 GSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQ---HKLAKSGS-GGSNNPMA 538

  Rat   530 RLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEES 594
            ..|..||.     ...|.:.:.....|...:.|..:.:..|.......|...|.:.|:...|::.
  Fly   539 PTPKGRIS-----FQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDH 598

  Rat   595 E--------GRRDSLFIPIRARERRSSYSGYSGYSQCSRSSRIFPSLRRSVKRNSTVDCNGVVSL 651
            |        |...::.:.:..||.|                              .:.|||.::.
  Fly   599 EEQDTTNDMGHVSTVELALSPREVR------------------------------LIKCNGNIAR 633

  Rat   652 IGPGSHIGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRK 716
            | ...::..|..|.::||                                   .::::|.:  |.
  Fly   634 I-KNHNVYALHQEFSSEV-----------------------------------VVIDDLPD--RN 660

  Rat   717 CPPCWYKFANTFLIWECHPY--WIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQF 779
            |..|.:        | |..|  |::.:..:..:|.||..:||||:||||||.|:|||||.|:..|
  Fly   661 CDRCVH--------W-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESF 716

  Rat   780 EHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSF 844
            .:.|.|||.|||.|||.|..:||:|:.. .:|..||||||..||:.||:::....|:||||||..
  Fly   717 RNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGL 780

  Rat   845 RLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQE 909
            |||||.|||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|.:.:
  Fly   781 RLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD 843

  Rat   910 CKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQAMCLIVFMMVMVIGNLVVLNLFL 971
             .:|||:.|||||||:::||:|||||||.:||||   |..|.:.|..:|:..:|:||.:||||||
  Fly   844 -PVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFL 907

  Rat   972 ALLLSSFSADNLAATDDD-GEMNNLQISVIRI-----KKGVAWTKVKVHAF-----------MQA 1019
            ||||:||:::.|.:..:: ||.:.|..|:.|:     ||.......|...|           .||
  Fly   908 ALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQA 972

  Rat  1020 HFKQ---------READEVKPLDEL------YEKKANCIAN--------------HT---GVDIH 1052
            |.:.         ...|:...|.|.      |::..|...:              ||   |::..
  Fly   973 HAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYD 1037

  Rat  1053 RNGDFQK-----------------------------------NGNGT------------------ 1064
            ..||..:                                   |||||                  
  Fly  1038 DTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQI 1102

  Rat  1065 ---------------------------------------TSGIGS----------SVEKYIIDED 1080
                                                   .||.||          |..:|..:|.
  Fly  1103 SSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEH 1167

  Rat  1081 HMSFIN-NPNLTVRVP------------------------------------------------- 1095
            ..:|:. ..:|..|.|                                                 
  Fly  1168 DEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLS 1232

  Rat  1096 -------------------------------------------------------IAVGESDFEN 1105
                                                                   ..|..|:|:|
  Fly  1233 QQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDN 1297

  Rat  1106 L------NTEDV-----------SSESDPEGSKD------------------------------- 1122
            :      ..|::           |:.|:|..:.|                               
  Fly  1298 IIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNP 1362

  Rat  1123 ------------------------------------KLDD------------------------- 1126
                                                |:|:                         
  Fly  1363 YDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAM 1427

  Rat  1127 ----TSSSEG----------------------STIDIKPEVEEVP-------------------- 1145
                ||:|:.                      ..:.:...|||||                    
  Fly  1428 AVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKF 1492

  Rat  1146 ----------------------------------------------------------------- 1145
                                                                             
  Fly  1493 LHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTP 1557

  Rat  1146 -------------------------------------------VEQPEEYLD------------- 1154
                                                       :|.|:..||             
  Fly  1558 PLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESH 1622

  Rat  1155 ----------------------------------------------------------------- 1154
                                                                             
  Fly  1623 SSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGA 1687

  Rat  1155 ------------------PDACFTEGCVQR--FKC-----CQVNIEEGLGKSWWILRKTCFLIVE 1194
                              ||.||.:.|...  |:|     |   ::....|.|..:|.....:|:
  Fly  1688 YNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC---MDTQSAKHWTRVRTAVLTVVD 1749

  Rat  1195 HNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFT 1259
            ...||.|::.:|..||..|.||||.:::.||::.:|.:.:..|..||::||:|||.|.||.|:||
  Fly  1750 TPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFT 1814

  Rat  1260 NAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPS 1324
            :.|..|||:||.||:.||:...  ...|..::|||||||||||||:||::|||:|||||:.||||
  Fly  1815 SFWTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPS 1877

  Rat  1325 IMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIDIVNNKTDCEKLMEGNSTEIRWKN 1389
            |.|||||||:||||||||||..|.||:..|.||..|: ..|..||:|.||   :|.|.|   |.|
  Fly  1878 IFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGEL-LPITEVNDKWDC---IEQNYT---WIN 1935

  Rat  1390 VKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPDYEGNIYMYIYFVIFIIFGSFFTL 1454
            .||.||:||.|||||||||||:|||::|..|||:|..|.||..|.|:|.||||||||:.||||||
  Fly  1936 SKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTL 2000

  Rat  1455 NLFIGVIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFV 1517
            ||||||||||||..|||:.|  .::|:||.||.||.||||||.|||||.|.||:|....:.:|..
  Fly  2001 NLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLS 2065

  Rat  1518 TQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIG 1582
            ..:.|:|.|.:||.|||:||.:|...|...:..||...|..|...|..|.::|:..||::|||:.
  Fly  2066 NSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVP 2130

  Rat  1583 WNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLP 1647
            ||:|||::|:.||.|:.:.||:....:||||.||:|:.||||||||||.|||||.|||||::|||
  Fly  2131 WNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLP 2195

  Rat  1648 ALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPI 1712
            ||||||.||.|:.||::|.|||.|..||.:..:|||.||:|||.||..||::.|||||:.:|..:
  Fly  2196 ALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESL 2260

  Rat  1713 LNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADP 1777
            :.:||||  |....|. ..|:||:|.:.|.:|.|:||||::||:|||||||||||:.|.:|....
  Fly  2261 MIQPPDC--DPFIHGH-TNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIG 2322

  Rat  1778 LSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHC 1842
            :.|||.|.||..|.|:||.|||||.:.:|:||..:|:.||.:.|||.:.|::.:||:..|::|||
  Fly  2323 IVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHC 2387

  Rat  1843 LDILFAFTKRVLGDSGELD---ILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAY 1904
            ||||.|..|.|||...|.|   .|::||:.:|....|::...|.:::|...|::|.:|..:|..:
  Fly  2388 LDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGW 2452

  Rat  1905 RGHL--------------------------------------ARRGFICRKMASN-KLENGGTHR 1930
            :.:|                                      :|||..|...||: |........
  Fly  2453 KEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDAS 2517

  Rat  1931 DKKESTPSTASLP-----SYDSVTKPDKEKQQRAEEGRR-------ERAKRQK 1971
            |..|......:||     ..|.|.|  ..|||..|.|:|       .||.|::
  Fly  2518 DLSELAGPWLNLPLMLVSGADEVVK--DIKQQNDELGKRGSIFVEAPRASRRR 2568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Scn8aNP_062139.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..62 2/8 (25%)
I. /evidence=ECO:0000305 114..442 150/347 (43%)
Ion_trans 131..421 CDD:395416 140/294 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..530 20/103 (19%)
Na_trans_cytopl 504..700 CDD:403218 30/203 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 576..597 5/28 (18%)
II. /evidence=ECO:0000305 733..1005 141/282 (50%)
Ion_trans 750..963 CDD:395416 116/215 (54%)
Na_trans_assoc 989..1190 CDD:399489 72/822 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1105..1146 16/303 (5%)
III. /evidence=ECO:0000305 1178..1493 177/316 (56%)
Ion_trans 1195..1471 CDD:395416 160/275 (58%)
Na_channel_gate 1463..1515 CDD:240441 30/53 (57%)
IV. /evidence=ECO:0000305 1502..1799 149/296 (50%)
Ion_trans 1520..1774 CDD:395416 132/253 (52%)
GPHH 1786..1833 CDD:407139 21/46 (46%)
IQ 1892..1913 CDD:197470 6/58 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1923..1978 16/61 (26%)
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 112/229 (49%)
Ion_trans 705..902 CDD:278921 105/200 (53%)
Ion_trans 1768..2019 CDD:278921 156/259 (60%)
Na_channel_gate 2009..2063 CDD:240441 30/53 (57%)
Ion_trans 2085..2320 CDD:278921 124/237 (52%)
GPHH 2331..2386 CDD:293510 24/54 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.720

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