Protein Alignment Gabrg2 and Rdl

DIOPT Version :10

• Sequence 1: NP_001380704.1
• Gene: Gabrg2 / 29709
• RGDID: 61966
• Length: 474
• Species: Rattus norvegicus
• Sequence 2: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Alignment Length: 597
• Identity: 162/597 - (27%)
• Similarity: 252/597 - (42%)
• Gaps: 167/597 - (27%)

  Rat    22 MTLWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTV--ILNNLLEGYDNKLRPDI 84
            :|:|:.:.::|....|..|.....:......:.:       |||.:  ||::....||.::||:.
  Fly    21 LTIWLAINMALIAQETGHKRIHTVQAATGGGSML-------GDVNISAILDSFSVSYDKRVRPNY 78

  Rat    85 GVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNST--IKVLRLNSNMVGKIWIP 147
            |..|..:...|||.||..::.:.|::|:|.:|.|.|.|.||.:...  ::.|.:.|..:..||:|
  Fly    79 GGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVP 143

  Rat   148 DTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGY 212
            ||||.|.|::..|..||.|..:|:.:.|.:..::||||.|.|.:.|..||||...|.:|..|:||
  Fly   144 DTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGY 208

  Rat   213 PREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQ 277
            ...:|.|.|:.....||.:....|.||..:|.|.....:..|:|:|..::......|.|||:.||
  Fly   209 TMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEINLTTGNYSRLACEIQFVRSMGYYLIQ 273

  Rat   278 TYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCF 342
            .|||..|||::||||||:|::|.|||.:||:|||||||||.:....:|||:|||.::|:::..||
  Fly   274 IYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCF 338

  Rat   343 IFVFSALVEYGTLHYFVSNRKPSKDK--------DKKKK------------NPLLRM-------- 379
            :.||::|:||.|:.|.....:..|.:        ::||:            ||...:
  Fly   339 VMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQQQANPNPNANVGGPGGVGV 403

  Rat   380 --------------------------------FSFKAP-----TIDIRPRS-ATIQMNNATHLQE 406
                                            .|...|     |:..||.. :.||.|..|
  Fly   404 GPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGT---- 464

  Rat   407 RDEEYGYECLDGKDCASFFCCFEDC-----------------------RTGAWRHG--------- 439
                        :.|:.....|::.                       |.|...||
  Fly   465 ------------RGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGP 517

  Rat   440 ---------------------------RIH---------------IRIAKMDSYARIFFPTAFCL 462
                                       .:|               |..:.:|.|:||.||..|..
  Fly   518 PGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVCFVC 582

  Rat   463 FNLVYWVSYLYL 474
            |||:||:.||::
  Fly   583 FNLMYWIIYLHV 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gabrg2	NP_001380704.1	LIC	68..471	CDD:455710	152/544 (28%)
		LGIC_ECD_GABAAR_G	89..270	CDD:349801	60/182 (33%)
		Cys-loop	189..203	CDD:349801	6/13 (46%)
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	60/182 (33%)
		Cys-loop	185..199	CDD:349809	6/13 (46%)
		Neur_chan_memb	274..588	CDD:460753	76/329 (23%)