DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gabrg2 and Rdl

DIOPT Version :9

Sequence 1:	NP_001380704.1	Gene:	Gabrg2 / 29709	RGDID:	61966	Length:	474	Species:	Rattus norvegicus
Sequence 2:	NP_001261617.1	Gene:	Rdl / 39054	FlyBaseID:	FBgn0004244	Length:	608	Species:	Drosophila melanogaster

Alignment Length:	597	Identity:	162/597 - (27%)
Similarity:	252/597 - (42%)	Gaps:	167/597 - (27%)

- Green bases have known domain annotations that are detailed below.

  Rat    22 MTLWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTV--ILNNLLEGYDNKLRPDI 84
            :|:|:.:.::|....|..|.....:......:.:       |||.:  ||::....||.::||:.
  Fly    21 LTIWLAINMALIAQETGHKRIHTVQAATGGGSML-------GDVNISAILDSFSVSYDKRVRPNY 78

  Rat    85 GVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNST--IKVLRLNSNMVGKIWIP 147
            |..|..:...|||.||..::.:.|::|:|.:|.|.|.|.||.:...  ::.|.:.|..:..||:|
  Fly    79 GGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVP 143

  Rat   148 DTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGY 212
            ||||.|.|::..|..||.|..:|:.:.|.:..::||||.|.|.:.|..||||...|.:|..|:||
  Fly   144 DTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGY 208

  Rat   213 PREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQ 277
            ...:|.|.|:.....||.:....|.||..:|.|.....:..|:|:|..::......|.|||:.||
  Fly   209 TMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEINLTTGNYSRLACEIQFVRSMGYYLIQ 273

  Rat   278 TYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCF 342
            .|||..|||::||||||:|::|.|||.:||:|||||||||.:....:|||:|||.::|:::..||
  Fly   274 IYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCF 338

  Rat   343 IFVFSALVEYGTLHYFVSNRKPSKDK--------DKKKK------------NPLLRM-------- 379
            :.||::|:||.|:.|.....:..|.:        ::||:            ||...:
  Fly   339 VMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQQQANPNPNANVGGPGGVGV 403

  Rat   380 --------------------------------FSFKAP-----TIDIRPRS-ATIQMNNATHLQE 406
                                            .|...|     |:..||.. :.||.|..|
  Fly   404 GPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGT---- 464

  Rat   407 RDEEYGYECLDGKDCASFFCCFEDC-----------------------RTGAWRHG--------- 439
                        :.|:.....|::.                       |.|...||
  Fly   465 ------------RGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGP 517

  Rat   440 ---------------------------RIH---------------IRIAKMDSYARIFFPTAFCL 462
                                       .:|               |..:.:|.|:||.||..|..
  Fly   518 PGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVCFVC 582

  Rat   463 FNLVYWVSYLYL 474
            |||:||:.||::
  Fly   583 FNLMYWIIYLHV 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gabrg2	NP_001380704.1	LIC	68..471	CDD:273305	152/544 (28%)
Gabrg2	NP_001380704.1	LGIC_ECD_GABAAR_G	89..270	CDD:349801	60/182 (33%)
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	60/182 (33%)
Rdl	NP_001261617.1	Neur_chan_memb	274..588	CDD:397193	76/329 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910