DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prkar2a and Pka-R1

DIOPT Version :9

Sequence 1:	NP_062137.1	Gene:	Prkar2a / 29699	RGDID:	3393	Length:	401	Species:	Rattus norvegicus
Sequence 2:	NP_001189150.1	Gene:	Pka-R1 / 40305	FlyBaseID:	FBgn0259243	Length:	464	Species:	Drosophila melanogaster

Alignment Length:	372	Identity:	139/372 - (37%)
Similarity:	199/372 - (53%)	Gaps:	42/372 - (11%)

- Green bases have known domain annotations that are detailed below.

  Rat    39 RLREARRQ-----ESDSFIAPPTTFH----AQESSGVPVIEEDGESE------------SDSDDE 82
            |:|..|..     |.|:........|    |:|......:|...|.|            |..|.|
  Fly    99 RMRHVRTSCTTIPEEDAVSDRSLQIHLSTLAREREQELELERQREREEQVKLDASRQVISPDDCE 163

  Rat    83 DLEVPIPS----KFTRRVSVCAETFNPDEEED--NDPRVVHPKTDEQRYRLQEACKDILLFKNLD 141
            ||. |:|.    ...||..:.||   |..|||  |..:.|.||..:....|.:|....:||.:||
  Fly   164 DLS-PMPQTAAPPVRRRGGISAE---PVTEEDATNYVKKVVPKDYKTMNALSKAIAKNVLFAHLD 224

  Rat   142 QEQLSQVLDAMFEKIVKTDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTR-SVGQYDNRGSFGE 205
            :.:.|.:.||||.......|::|.|||:|||||||:.|..|:.|..:..|. |.|     |||||
  Fly   225 ESERSDIFDAMFPVNHIAGENIIQQGDEGDNFYVIDVGEVDVFVNSELVTTISEG-----GSFGE 284

  Rat   206 LALMYNTPRAATIVATSDGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLFKSLEMSERMKI 270
            |||:|.||||||:.|.:|..|||:||.::|||::.:..:||||:|.|:..|.:.:||:..||:.:
  Fly   285 LALIYGTPRAATVRAKTDVKLWGIDRDSYRRILMGSTIRKRKMYEEFLSRVSILESLDKWERLTV 349

  Rat   271 VDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSKTKTNKNGGNQEVEIAHCHKGQYFGE 335
            .|.:....:.|||.|:.||...|.||||..| .:::::.:::.    |....|:.......||||
  Fly   350 ADSLETCSFDDGETIVKQGAAGDDFYIILEG-CAVVLQQRSEQ----GEDPAEVGRLGSSDYFGE 409

  Rat   336 LALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHY 382
            :||:.::||||:..|.|.:||:.:|...|||:||||.||:||||:.|
  Fly   410 IALLLDRPRAATVVARGPLKCVKLDRARFERVLGPCADILKRNITQY 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prkar2a	NP_062137.1	Dimerization and phosphorylation	2..135		32/122 (26%)
		DD_RIIalpha_PKA	4..44	CDD:213050	2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..85		10/45 (22%)
		Crp	132..>241	CDD:223736	52/109 (48%)
		CAP_ED	136..248	CDD:237999	54/112 (48%)
		Crp	252..>368	CDD:223736	39/115 (34%)
		CAP_ED	258..379	CDD:237999	45/120 (38%)
Pka-R1	NP_001189150.1	Crp	213..>339	CDD:223736	60/130 (46%)
		CAP_ED	219..328	CDD:237999	55/113 (49%)
		Crp	331..>442	CDD:223736	39/115 (34%)
		CAP_ED	337..453	CDD:237999	45/120 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54324
OrthoDB	1	1.010	-	-		D1047290at2759
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100449
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X421
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730