DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kcnq3 and KCNQ

DIOPT Version :9

Sequence 1:	NP_113785.4	Gene:	Kcnq3 / 29682	RGDID:	69222	Length:	873	Species:	Rattus norvegicus
Sequence 2:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster

Alignment Length:	1020	Identity:	300/1020 - (29%)
Similarity:	433/1020 - (42%)	Gaps:	346/1020 - (33%)

- Green bases have known domain annotations that are detailed below.

  Rat    74 GREEGQRRTPQGIGLLAKTPL--SRPVKRNNAKYRRIQTLIYDALERPRG-WALLYHALVFLIVL 135
            ||...:|.....:.||.| ||  :|..:| :.:|||:|:.:|:.|||||| .|:.||.:|||:|.
  Fly    23 GRPNSERILQPRMSLLGK-PLNYNRGTRR-DVRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVF 85

  Rat   136 GCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLC 200
            .||.|:|.:|.||||..:...|..:|...:..|..||..|:|::||..||:|..|||||.::|.|
  Fly    86 TCLALSVFSTIKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFC 150

  Rat   201 MLDIFVLIASVPVVAVGNQGNVLATS-LRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELIT 264
            ::||..::||:.|:.:|..|.|.||| ||.|||.|||||:||||||||||||||.:.||.:||||
  Fly   151 IIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELIT 215

  Rat   265 AWYIGFLTLILSSFLVYLVEKDVPEMDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWE 329
            ..|||||.||.:|||||:.||||          .::|..:|.|||||:|||.|:||||..|.||:
  Fly   216 TMYIGFLGLIFASFLVYMWEKDV----------NDKFSNFAQALWWGVITLCTVGYGDMVPITWQ 270

  Rat   330 GRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRL 394
            |:|||:..:|:|:|||||||||||||.|||||:|.||||..:||:|||.||||.||.||.:.:.:
  Fly   271 GKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSV 335

  Rat   395 DLVATWRFY--------------------ESVVSFPFFRKEQLEAAASQKLGLLDRVRLSNPRGS 439
            . ||||..:                    ..|...|..|:.:.:..  |..|..|...:|.|.||
  Fly   336 S-VATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRHKSQTI--QTPGGGDGGGVSKPPGS 397

  Rat   440 NTKGKLFTPL---------NVDAIEESPSKEP----------------------KPVGLNN---- 469
            :.....:|..         |::.::...|..|                      :|..|.|
  Fly   398 SRASTRYTRTIRDINASVENLEVVQNGKSMNPSFSEDSVAETTCLKNIKNSDASQPATLANCKLS 462

  Rat   470 -----------KERFRTAFR--------------MKA-------------YAFWQSS-------- 488
                       :.|.|...|              .||             |.|...:
  Fly   463 SSAGSLAQFPDRNRDRDQDRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLHGNFLGSTLSL 527

  Rat   489 --------------------------------------EDAGTGDPMTE-------------DRG 502
                                                  .|:.:|.|.:.             :.|
  Fly   528 RNPRVAPANDRDLEAGRDEDEVHKDTCQRSNTLPLPVKPDSPSGSPGSGRTGRFFAAASHFLETG 592

  Rat   503 YGN-----DFLIEDMIPTL-------KAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGH 555
            :.:     |...|:..|..       |.|||.:|.|::.:.::||||.|:|||||||:|||:|||
  Fly   593 FSSPNPIIDVANEEDEPRCTQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYAAGH 657

  Rat   556 LDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTYPSQQSPRNEPYVARAATSETEDQSMM 620
            :|:|.|:|.|..|:|.|.                     ..|.|...:.|.::.        |:.
  Fly   658 VDLLGRVKMLHLRLDQIL---------------------GKQGSKAKDVYASKI--------SLA 693

  Rat   621 GKFVKVERQVHDMGKKLDFLVDMHMQHMERL---------QVH---------------------- 654
            .:.|||||||.|:.:|||.|:..:|:..:|.         ::|
  Fly   694 SRVVKVERQVADIEEKLDILIKAYMEDRDRFLALPLPAKPKIHSISPSHKPLHHAHNLAMIDVWK 758

  Rat   655 ---VTEYYPTKGASSPAEGEKKEDNRYSDLKTIICNYSESGPPD--------PPYSFHQVPIDRV 708
               ....:|.:..::|.......|:  |:|:::....:.:...|        ||:..|..
  Fly   759 RTAALSVHPEQVTTTPLLNPSAPDS--SELRSLTATQTPTTTTDAIATQTPMPPHVQHTA----- 816

  Rat   709 GPYGFFAHDPVKLTRGGPSSTKAQA-NLPSSGSTYAERPTVLPILTLLDS------CVSYHSQTE 766
                              ::||:.. |....||...:...|  .:|.|::      .:|.|..|
  Fly   817 ------------------TNTKSSVLNSYQLGSEKQQHNDV--FMTELENRTKKRVTLSLHRST- 860

  Rat   767 LQGPYSDHISPRQRRSIT-----RDS----------DTPLSLM---------SVNHE-ELERSPS 806
             ..|||     :|.:.||     .||          |:.:.|:         .:|.| |::..|:
  Fly   861 -SEPYS-----KQEQRITIPDEGADSLDSSAKPTPPDSSIILIDEYEDFEEEDLNCEGEMDHFPT 919

  Rat   807 -------GFSISQDRDDYVFGPSGGSSWMREKRYLAEGETDTDTD 844
                   |..:..|.|                   |:|:.|..|:
  Fly   920 WEIDSDIGVEVDVDAD-------------------ADGDCDESTE 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kcnq3	NP_113785.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		Ion_trans	122..364	CDD:395416	134/242 (55%)
		Selectivity filter. /evidence=ECO:0000250	317..322		3/4 (75%)
		Mediates interaction with calmodulin. /evidence=ECO:0000250\|UniProtKB:O43525	357..538		67/344 (19%)
		KCNQ_channel	447..651	CDD:397540	70/347 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..603		2/27 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	723..742		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..873		21/111 (19%)
		KCNQC3-Ank-G_bd	771..867	CDD:403240	20/106 (19%)
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	119/214 (56%)
		Ion_trans_2	221..295	CDD:285168	47/83 (57%)
		KCNQ_channel	<619..719	CDD:281513	48/128 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I1342
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	474	1.000	Inparanoid score	I1440
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168835at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44832
orthoMCL	1	0.900	-	-		OOG6_102886
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X604
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.930