DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp11a1 and Cyp12a5

DIOPT Version :9

Sequence 1:	NP_058982.1	Gene:	Cyp11a1 / 29680	RGDID:	69325	Length:	526	Species:	Rattus norvegicus
Sequence 2:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	130/514 - (25%)
Similarity:	225/514 - (43%)	Gaps:	65/514 - (12%)

- Green bases have known domain annotations that are detailed below.

  Rat    41 NSP-----RSFNEIPSPGDNGWINLYHFLRENGTHRIHYHHMQNF-------QKYGPI--YREKL 91
            |.|     :.|.|||.      .|:.....::......|.:::..       |.||.|  ....:
  Fly    37 NDPEWLQAKPFEEIPK------ANILSLFAKSALPGGKYKNLEMMEMIDALRQDYGNIIFLPGMM 95

  Rat    92 GNMESVYILDPKDAATLFSCEGPNPERYLVPPW---VAYHQ------YYQRPIGVLFKSSDAWRK 147
            |....|...:|||...:|..||..|.|    |.   :.||:      ::....|::.....:|..
  Fly    96 GRDGLVMTHNPKDFEVVFRNEGVWPFR----PGSDILRYHRTVYRKDFFDGVQGIIPSQGKSWGD 156

  Rat   148 DRIVLNQEVMAPDSIKNFVPLLEGVAQDFIKVLHRRIKQQNSGKFSGDISDDLFRFAFESITSVV 212
            .|.::|..:|.|.:::.:...:..|.|:|:::: :.|:..::.:..|:..:.:.|:..||::.|.
  Fly   157 FRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELI-KEIRDASTQEVPGNFLETINRWTLESVSVVA 220

  Rat   213 FGERLGMLEEI-VDPESQRFIDAVYQMFHTSVPMLNMPPDLFRLFRTKTWKDHAAAWD----VIF 272
            ..::||:|.|. .:.|:.:....:.:.|..|.. |.|.|.|:|.|:|...|......|    |..
  Fly   221 LDKQLGLLRESGKNSEATKLFKYLDEFFLHSAD-LEMKPSLWRYFKTPLLKKMLRTMDSVQEVTL 284

  Rat   273 SKADEYTQNFYWD-----LRQKRDFSKYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTL 332
            ...||..:....:     :|.:.:.|    ||..||   |:..|.......:||..||||||.|.
  Fly   285 KYVDEAIERLEKEAKEGVVRPEHEQS----VLEKLL---KVDKKVATVMAMDMLMAGVDTTSSTF 342

  Rat   333 QWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAK-MVQLVPLLKASIKETLRLHPISVTLQRYIV 396
            ...|..:|.|.:.|..||.||:........:..: .::.||.|:|.|||:.|::|:.:...|.:.
  Fly   343 TALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEASMKNVPYLRACIKESQRVYPLVIGNARGLT 407

  Rat   397 NDLVLRNYKIPAKTLVQVASYAMGRESSFFPNPNKFDPTRWLEKSQNT------------THFRY 449
            .|.|:..|::||.|:|.:..........:||.|.:|.|.|||..:.::            ..|.:
  Fly   408 RDSVISGYRVPAGTIVSMIPINSLYSEEYFPKPTEFLPERWLRNASDSAGKCPANDLKTKNPFVF 472

  Rat   450 LGFGWGVRQCLGRRIAELEMTIFLINVLENFRIEVQSIRDVGTKFNLILMPEKPIFFNF 508
            |.||:|.|.|:|:||.|:|:.:....::.||.:|.........:..||.:|..|:.|.|
  Fly   473 LPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNHSTKNAFRSALINLPNIPLKFKF 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp11a1	NP_058982.1	cytochrome_P450	80..505	CDD:425388	120/465 (26%)
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	121/462 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820