DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ap1b1 and AP-1-2beta

DIOPT Version :10

Sequence 1:NP_001295227.1 Gene:Ap1b1 / 29663 RGDID:2064 Length:949 Species:Rattus norvegicus
Sequence 2:NP_523415.1 Gene:AP-1-2beta / 32987 FlyBaseID:FBgn0010380 Length:921 Species:Drosophila melanogaster


Alignment Length:951 Identity:708/951 - (74%)
Similarity:802/951 - (84%) Gaps:33/951 - (3%)


- Green bases have known domain annotations that are detailed below.


  Rat     1 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65
            |||||||||||||||||||:|||:|||||||||||||||||||||||||||||||||||||||||
  Fly     1 MTDSKYFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65

  Rat    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
            ||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||
  Fly    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130

  Rat   131 KDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSN 195
            ||||||||||||||||||:||:|.:||||||||.||||:||||||||||||||||||.|:..|..
  Fly   131 KDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQ 195

  Rat   196 -LLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSA 259
             |:::|..:||||||||||||||||:||||.||||.|||:|||||||||:||||:|||:||||||
  Fly   196 PLVEMNSVTINKLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSA 260

  Rat   260 VKVLMKFMEMLSKDLDYYATLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVF 324
            ||||||.:||||.|.|:.|||.||||||||||||:|||:||||||||||||||||:|||||||||
  Fly   261 VKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVF 325

  Rat   325 FVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAE 389
            ||||||||||||||||||||||:|:||||||:|||||||||||||||||||||||||||||.|||
  Fly   326 FVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAE 390

  Rat   390 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGE 454
            ||||||||||||||||||||||||||||||||||||||:|:|||||||:||||||||:|:||:||
  Fly   391 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGE 455

  Rat   455 YAERIDNADELLESFLDGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDL 519
            ||||||||||||:|||:||.||:.|||||||||:||||||:|::||||||.||||||||||||||
  Fly   456 YAERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDL 520

  Rat   520 RDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPNAFVEG 584
            ||||:||||||||||.||||||||:||||||||||:||||||||||:|.:|||||||||.|||||
  Fly   521 RDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEG 585

  Rat   585 GRGVVHKSLPPRTASSESTESPEAAPAGAPASDQPDVIPAQGDLLGDLLNLDL-GPPVSGPPLAA 648
            ....|.||||.|.|.|.:........||:.|.    |||.|..|:||||::|: .|.:...|.|.
  Fly   586 RGAGVRKSLPNRAAGSAAGAEQAENAAGSEAM----VIPNQESLIGDLLSMDINAPAMPSAPAAT 646

  Rat   649 SSVQMGAVDLLGGGLDSLMGDEPEGIGDSNFGAPPASVAAAAPARLGAPVSSGLSDLFDLTSGVG 713
            |:     |||||||||.|:            |.|||.   |||.  ||  :|.|.|:|.|  |..
  Fly   647 SN-----VDLLGGGLDILL------------GGPPAE---AAPG--GA--TSLLGDIFGL--GGA 685

  Rat   714 TLSGSYVAPKAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAP 778
            |||.....||..||||.|.|||||.|||:|:.|.:.||:.|||||:|.||:||||.|:|||||.|
  Fly   686 TLSVGVQIPKVTWLPAEKGKGLEIQGTFSRRNGEVFMDMTLTNKAMQPMTNFAIQLNKNSFGLVP 750

  Rat   779 AAPLQVHAPLSPNQTVEISLPLNTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHVLFVEDGK 843
            |:|:|. |||.|||::|:|:.|.|.|.:.:||||||||||||||||:|||:.|...:|||.|||:
  Fly   751 ASPMQA-APLPPNQSIEVSMALGTNGPIQRMEPLNNLQVAVKNNIDIFYFACLVHGNVLFAEDGQ 814

  Rat   844 MDRQMFLATWKDIPNENEAQFQIRDCPLNTEAASSKLQSSNIFTVAKRTVEGQDMLYQSLKLTNG 908
            :|:::||.|||:||..||.|:.:......|:..:||:.::||||:|||.|||||||||||||||.
  Fly   815 LDKRVFLNTWKEIPAANELQYTLSGVIGTTDGIASKMTTNNIFTIAKRNVEGQDMLYQSLKLTNN 879

  Rat   909 IWVLAELRIQPGNPSFTLSLKCRAPEVSQHVYQAYETILKN 949
            ||||.||::|||||..|||||.|:.||:..::.|||.|:::
  Fly   880 IWVLLELKLQPGNPEATLSLKSRSVEVANIIFAAYEAIIRS 920

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ap1b1NP_001295227.1 Adaptin_N 11..534 CDD:396262 463/523 (89%)
HEAT repeat 51..75 CDD:293787 23/23 (100%)
HEAT repeat 87..114 CDD:293787 25/26 (96%)
HEAT repeat 121..151 CDD:293787 28/29 (97%)
HEAT repeat 160..186 CDD:293787 23/25 (92%)
HEAT repeat 197..228 CDD:293787 22/30 (73%)
HEAT repeat 392..416 CDD:293787 23/23 (100%)
HEAT repeat 428..457 CDD:293787 22/28 (79%)
HEAT repeat 464..494 CDD:293787 23/29 (79%)
HEAT repeat 505..541 CDD:293787 32/35 (91%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 592..623 10/30 (33%)
Alpha_adaptinC2 729..829 CDD:197886 65/99 (66%)
B2-adapt-app_C 838..948 CDD:198088 63/109 (58%)
AP-1-2betaNP_523415.1 Adaptin_N 38..535 CDD:396262 438/496 (88%)
HEAT repeat 51..75 CDD:293787 23/23 (100%)
HEAT repeat 87..114 CDD:293787 25/26 (96%)
HEAT repeat 121..151 CDD:293787 28/29 (97%)
HEAT repeat 160..186 CDD:293787 23/25 (92%)
HEAT repeat 197..229 CDD:293787 23/31 (74%)
HEAT repeat 393..417 CDD:293787 23/23 (100%)
HEAT repeat 429..458 CDD:293787 22/28 (79%)
HEAT repeat 465..495 CDD:293787 23/29 (79%)
HEAT repeat 506..542 CDD:293787 32/35 (91%)
Alpha_adaptinC2 703..799 CDD:197886 63/96 (66%)
B2-adapt-app_C 809..919 CDD:198088 63/109 (58%)

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