DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ap1b1 and AP-1-2beta

DIOPT Version :9

Sequence 1:	XP_038947721.1	Gene:	Ap1b1 / 29663	RGDID:	2064	Length:	952	Species:	Rattus norvegicus
Sequence 2:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster

Alignment Length:	954	Identity:	708/954 - (74%)
Similarity:	802/954 - (84%)	Gaps:	36/954 - (3%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65
            |||||||||||||||||||:|||:|||||||||||||||||||||||||||||||||||||||||
  Fly     1 MTDSKYFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLEL 65

  Rat    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130
            ||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||
  Fly    66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130

  Rat   131 KDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSN 195
            ||||||||||||||||||:||:|.:||||||||.||||:||||||||||||||||||.|:..|..
  Fly   131 KDEDPYVRKTAAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQ 195

  Rat   196 -LLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSA 259
             |:::|..:||||||||||||||||:||||.||||.|||:|||||||||:||||:|||:||||||
  Fly   196 PLVEMNSVTINKLLTALNECTEWGQVFILDSLANYSPKDEREAQSICERITPRLAHANAAVVLSA 260

  Rat   260 VKVLMKFMEMLSKDLDYYATLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVF 324
            ||||||.:||||.|.|:.|||.||||||||||||:|||:||||||||||||||||:|||||||||
  Fly   261 VKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVF 325

  Rat   325 FVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAE 389
            ||||||||||||||||||||||:|:||||||:|||||||||||||||||||||||||||||.|||
  Fly   326 FVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAE 390

  Rat   390 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGE 454
            ||||||||||||||||||||||||||||||||||||||:|:|||||||:||||||||:|:||:||
  Fly   391 RCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGE 455

  Rat   455 YAERIDNADELLESFLDGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDL 519
            ||||||||||||:|||:||.||:.|||||||||:||||||:|::||||||.||||||||||||||
  Fly   456 YAERIDNADELLDSFLEGFQDENAQVQLQLLTAVVKLFLKRPSDTQELVQHVLSLATQDSDNPDL 520

  Rat   520 RDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPNAFVEG 584
            ||||:||||||||||.||||||||:||||||||||:||||||||||:|.:|||||||||.|||||
  Fly   521 RDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEG 585

  Rat   585 GRGVVHKSLPPRTASSESTESPEAAPAGAPASDQPDVIPAQGDLLGDLLNLDL-GPPVSGPPLAA 648
            ....|.||||.|.|.|.:........||:.|.    |||.|..|:||||::|: .|.:...|.|.
  Fly   586 RGAGVRKSLPNRAAGSAAGAEQAENAAGSEAM----VIPNQESLIGDLLSMDINAPAMPSAPAAT 646

  Rat   649 SSVQMGAVDLLGGGLDSLMGDEPEGIGDSNFGAPPASVAAAAPARLGAPVSSGLSDLFDLTSGVG 713
            |:     |||||||||.|:            |.|||.   |||.  ||  :|.|.|:|.|  |..
  Fly   647 SN-----VDLLGGGLDILL------------GGPPAE---AAPG--GA--TSLLGDIFGL--GGA 685

  Rat   714 TLSGSYVAPKAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAP 778
            |||.....||..||||.|.|||||.|||:|:.|.:.||:.|||||:|.||:||||.|:|||||.|
  Fly   686 TLSVGVQIPKVTWLPAEKGKGLEIQGTFSRRNGEVFMDMTLTNKAMQPMTNFAIQLNKNSFGLVP 750

  Rat   779 AAPLQVHAPLSPNQTVEISLPLNTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHVLFVEDGK 843
            |:|:|. |||.|||::|:|:.|.|.|.:.:||||||||||||||||:|||:.|...:|||.|||:
  Fly   751 ASPMQA-APLPPNQSIEVSMALGTNGPIQRMEPLNNLQVAVKNNIDIFYFACLVHGNVLFAEDGQ 814

  Rat   844 MDRQMFLATWKDIPNENEAQFQIRDCPLNTEAASSKLQSSNIFTVAKRTVEGQDMLYQSLKLTNG 908
            :|:::||.|||:||..||.|:.:......|:..:||:.::||||:|||.|||||||||||||||.
  Fly   815 LDKRVFLNTWKEIPAANELQYTLSGVIGTTDGIASKMTTNNIFTIAKRNVEGQDMLYQSLKLTNN 879

  Rat   909 IWVLAELRIQPGNPSFTDLELSLKCRAPEVSQHVYQAYETILKN 952
            ||||.||::|||||..|   ||||.|:.||:..::.|||.|:::
  Fly   880 IWVLLELKLQPGNPEAT---LSLKSRSVEVANIIFAAYEAIIRS 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ap1b1	XP_038947721.1	Adaptin_N	11..534	CDD:396262	463/523 (89%)
		HEAT repeat	51..75	CDD:293787	23/23 (100%)
		HEAT repeat	87..114	CDD:293787	25/26 (96%)
		HEAT repeat	121..151	CDD:293787	28/29 (97%)
		HEAT repeat	160..186	CDD:293787	23/25 (92%)
		HEAT repeat	197..228	CDD:293787	22/30 (73%)
		HEAT repeat	392..416	CDD:293787	23/23 (100%)
		HEAT repeat	428..457	CDD:293787	22/28 (79%)
		HEAT repeat	464..494	CDD:293787	23/29 (79%)
		HEAT repeat	505..541	CDD:293787	32/35 (91%)
		Alpha_adaptinC2	729..829	CDD:197886	65/99 (66%)
		B2-adapt-app_C	838..951	CDD:198088	63/112 (56%)
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	438/496 (88%)
		HEAT repeat	51..75	CDD:293787	23/23 (100%)
		HEAT repeat	87..114	CDD:293787	25/26 (96%)
		Cnd1	99..269	CDD:289487	142/169 (84%)
		HEAT repeat	121..151	CDD:293787	28/29 (97%)
		HEAT repeat	160..186	CDD:293787	23/25 (92%)
		HEAT repeat	197..229	CDD:293787	23/31 (74%)
		HEAT repeat	393..417	CDD:293787	23/23 (100%)
		HEAT repeat	429..458	CDD:293787	22/28 (79%)
		HEAT repeat	465..495	CDD:293787	23/29 (79%)
		HEAT repeat	506..542	CDD:293787	32/35 (91%)
		Alpha_adaptinC2	703..799	CDD:197886	63/96 (66%)
		B2-adapt-app_C	809..919	CDD:198088	63/112 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354606
Domainoid	1	1.000	895	1.000	Domainoid score	I47
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21972
Inparanoid	1	1.050	1341	1.000	Inparanoid score	I132
OMA	1	1.010	-	-		QHG53641
OrthoDB	1	1.010	-	-		D158630at33208
OrthoFinder	1	1.000	-	-		FOG0001621
OrthoInspector	1	1.000	-	-		otm45185
orthoMCL	1	0.900	-	-		OOG6_100684
Panther	1	1.100	-	-	LDO	PTHR11134
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1351
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910