Protein Alignment GTF2H1 and Tfb1

DIOPT Version :9

• Sequence 1: NP_001135779.1
• Gene: GTF2H1 / 2965
• HGNCID: 4655
• Length: 548
• Species: Homo sapiens
• Sequence 2: NP_001246321.1
• Gene: Tfb1 / 36598
• FlyBaseID: FBgn0033929
• Length: 585
• Species: Drosophila melanogaster
• Alignment Length: 592
• Identity: 265/592 - (44%)
• Similarity: 372/592 - (62%)
• Gaps: 59/592 - (9%)

Human     1 MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGKAKIQL 65
            |.||||:|||.:.:||.||.||.||:|.||:||..|.:|..|:||.|||||.||||||||.|:||
  Fly     1 MTTSSEDVLLQMGEVRYKKGDGTLYVMNERVAWMAEHRDTVTVSHRYADIKTQKISPEGKPKVQL 65

Human    66 QLVLHAGDTTNFHFSN---ESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQEDPVLFQL 127
            |:|||.|:|:.|||.|   ::..:.:||.||:|||||||.||||.:|:||:|||:|.|:|.|.||
  Fly    66 QVVLHDGNTSTFHFVNRQGQAAMLADRDKVKELLQQLLPNFKRKVDKDLEDKNRILVENPNLLQL 130

Human   128 YKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQDVGISAAFLADVRPQTDGCNGLRYNLTSDI 192
            |||||:::|::::||||.....:|......|   |::|:|.|||||::|||||||||:||||||:
  Fly   131 YKDLVITKVLTSDEFWATHAKDHALKKMGRS---QEIGVSGAFLADIKPQTDGCNGLKYNLTSDV 192

Human   193 IESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTM 257
            |..||:||||||.|:.||||..|:|.||||:||||||||||||..|:||:|.||.|||::.||..
  Fly   193 IHCIFKTYPAVKRKHFENVPAKMSEAEFWTKFFQSHYFHRDRLTAGTKDIFTECGKIDDQALKAA 257

Human   258 VSLGVKNPLLDLTALEDKPLDEGYGISSVPSASNSKSIKENSNAA---IIKRFNHHSAMVLAAGL 319
            |..|..:|||||...||.||:||:|     |.:..:::..:.|..   :|||||.||.|||....
  Fly   258 VQQGAGDPLLDLKKFEDVPLEEGFG-----SVAGDRNVVNSGNIVHQNMIKRFNQHSIMVLKTCA 317

Human   320 RKQEAQNEQTSEPSNMDG------------------------NSGDADCFQPAVKRAKLQESIEY 360
            ....|.:..|:..:|.:|                        :|...|..:|..|:.:|.|.|.|
  Fly   318 NVTSAPSTMTNGTNNANGPVSQSAYTNGMNGKGQATATATKSSSDQVDKDEPQSKKQRLMEKIHY 382

Human   361 EDLG----------KNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEM---- 411
            .|||          .....|:....|.|.:||.:|  |:|:..|....|.: |.:.::.::
  Fly   383 VDLGDPILEGDDSANGEKAKSKHFELSKVERYLNG--PVQNSMYDNHNDPM-SLEEVQYKLVRNS 444

Human   412 EAYTPKLTQ--VLSSSAASSTITALSPGGALMQGGTQQAINQMVPNDIQSELKHLYVAVGELLRH 474
            |::..:..|  .:.|.||.:.:..|||||::|:|..:|:..|:||||.|.||:|||:::.|||:|
  Fly   445 ESWLNRNVQRTFICSKAAVNALGELSPGGSMMRGFQEQSAGQLVPNDFQRELRHLYLSLSELLKH 509

Human   475 FWSCFPVNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQY--LSTNLVSHIEEMLQTAYNKLH 537
            ||||||..:..||.|:.:|...|:||::.||.||:.:...:.  |.::|..|:.::|:||.:|..
  Fly   510 FWSCFPPTSEELETKLQRMHETLQRFKMAKLVPFENRAMHELSPLRSSLTQHLNQLLRTANSKFA 574

Human   538 TWQSRRL 544
            ||:.|:|
  Fly   575 TWKERKL 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GTF2H1	NP_001135779.1	PH_TFIIH	9..102	CDD:270049	56/95 (59%)
		BSD	101..148	CDD:128990	27/46 (59%)
		BSD	182..232	CDD:128990	36/49 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	321..340		4/42 (10%)
Tfb1	NP_001246321.1	PH_TFIIH	10..104	CDD:270049	54/93 (58%)
		BSD	104..157	CDD:128990	28/52 (54%)
		BSD	181..234	CDD:281847	39/52 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158972
Domainoid	1	1.000	198	1.000	Domainoid score	I3084
eggNOG	1	0.900	-	-		E1_KOG2074
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3885
Inparanoid	1	1.050	494	1.000	Inparanoid score	I1411
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S3315
OMA	1	1.010	-	-		QHG55753
OrthoDB	1	1.010	-	-		D355210at33208
OrthoFinder	1	1.000	-	-		FOG0004248
OrthoInspector	1	1.000	-	-		oto89351
orthoMCL	1	0.900	-	-		OOG6_103656
Panther	1	1.100	-	-	LDO	PTHR12856
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1500
SonicParanoid	1	1.000	-	-		X4051
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750