DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itgav and scb

DIOPT Version :9

Sequence 1:	XP_038962373.1	Gene:	Itgav / 296456	RGDID:	1310613	Length:	1043	Species:	Rattus norvegicus
Sequence 2:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster

Alignment Length:	1151	Identity:	291/1151 - (25%)
Similarity:	470/1151 - (40%)	Gaps:	242/1151 - (21%)

- Green bases have known domain annotations that are detailed below.

  Rat    47 SYFGFAVDFFVPSTSSRMFLLVGAPKANTT---QPGIIEGGQVLKCDCSSSRRCQPIEFDSTGNR 108
            ||||:.:  .:..||    ::||||:|.:|   |..|.|.|.:.:|..::. .|.|...||.||.
  Fly    51 SYFGYTL--VIRQTS----IIVGAPRAQSTLESQRTINETGAIYRCSLTNG-VCSPYVLDSRGNV 108

  Rat   109 D-----YAKDDPLEFKSHQWFGASV---RSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGT- 164
            |     |..|.  |.|..||.|.|:   ....||:|.|||.::  ....::....|.|:..:.|
  Fly   109 DAPYSEYTFDS--ERKDFQWLGGSMDGGTKDTDKLLVCAPRFY--APSSRDNHLHGVCYWVNNTV 169

  Rat   165 -----KTVEYAPCR--SKNIDADGQG------FCQGGFSIDFTKAD---RVLLGGPGSFYWQGQL 213
                 .....:|.|  |:.:..:..|      :..|...:....||   :.|:|.||...|:|.:
  Fly   170 ASTPQHVTRISPLRLKSEQVKEEDNGNKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSV 234

  Rat   214 I------------------SDQVAEIISKYDPNVYSIK-YNNQLATRTAQAIFDDSYLGYSVAVG 259
            |                  |..:.......|.|.|:.: |..::.|.......:|||.||:|:.|
  Fly   235 ILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSG 299

  Rat   260 DFNGDGIED--FVSGVPRAARTLGMVYIYD--GKNMSSLHNFTGEQMAAYFGFSVAATDINGDDY 320
            .|:......  :|:..|:|.:..|..||:|  ||::...|.|.|||...|||:||.|.|:|||..
  Fly   300 FFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGK 364

  Rat   321 ADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNG-FEVFARFGSAIAPLGDLDQDG 384
            .||.:.||......|    .:.|.:.|.:.:...:|:...|.. .|..||||:|::.|||::.||
  Fly   365 TDVIVSAPQHALEDS----HDNGAIYVFINKGFFNFERQILRSPVETMARFGTALSRLGDINHDG 425

  Rat   385 FNDIAIAAPYGGEDKKGLVYIFNGRSTGLNSVPSQILQGQWAAQSMPPS------FGYSMKGATD 443
            :||:|:.||:.|   .|.|:|:.|...||...|||.|.    |.|..||      ||:.:...:|
  Fly   426 YNDVAVGAPFAG---NGTVFIYLGSENGLRDQPSQRLD----APSQQPSKYGSHMFGHGLSRGSD 483

  Rat   444 VDRNGYPDLVVGAFGVDRAVLYRARPVVTVNAGLEVYPSILNQDNKICPLPGTALKVSCFNVRFC 508
            :|.||:.|..:||...:...||||.|||.|:|      ::.::..:|.|........:|:.
  Fly   484 IDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHA------TVKSESREIKPEQEKVKITACYR---- 538

  Rat   509 LKADGKGTLPRKLNFQVELLLDKLKQKGAIRRALFLHNRSPGHSKDMTVFRGGQTQCEELVAYLR 573
            |.......|.::....:.:.:||     .::|..|...::...|..:....|  .||.:....:|
  Fly   539 LSTTSTDKLVQEQELAIRIAMDK-----QLKRVKFTQTQTNEISFKVNANFG--EQCRDFETQVR 596

  Rat   574 DESEFRDKLTPITIFMEYRLDQRTAADATGLQPILNQF---------TPANVSRQAHILLDCG-E 628
             .|| :|..|||.:.|.|.|.::.        |...:|         |...||.| :|:...| .
  Fly   597 -YSE-KDIFTPIDLEMHYELTKKV--------PDSEEFCETCAIVDPTEPKVSTQ-NIIFSTGCA 650

  Rat   629 DNVCKPKLEVSVDSDQKKIYI-GDDNPLTLTVKAQNQGEGAYEAELIVSIPPQADFIGVVRNNEA 692
            .:||...|::. ..|....|| |..:.|.|..:..|.||.||..:..|:...:..|..|..|.:.
  Fly   651 TDVCTADLQLR-SKDVSPTYILGSADTLRLNYEITNIGETAYLPQFNVTSTSRLAFAQVPGNCKV 714

  Rat   693 LARLSCAFKTENQTRQVVCDL--GNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLKIQSS----N 751
            :..:            :||||  |.|:..|......:.|.|.|.|  ..|:....::.|:    |
  Fly   715 VDAV------------MVCDLNRGRPLAKGDTDSVTISFDVSQLS--GQSLIIHAEVFSTGYEQN 765

  Rat   752 SFDNVSPVVSYKVDLAVLAAVEIRGVSSPDHIFLPIPNWEYKETPETEEDVGPVVQHIYELRNNG 816
            ..||....|   :.|.....::..|..:...|.|.    .|..:.|        :.:.||:::||
  Fly   766 PTDNRQTNV---IGLKEFTEIDASGGQTNSQIDLE----HYSNSAE--------IVNNYEIKSNG 815

  Rat   817 PSSFSKAILNLQWP--YKYNNNTLLYILHYDIDGPMNCTADTEI---------NPLRIKTPEKND 870
            ||...:..::...|  ||...:|.:..:.......|..:.|:::         |.:.:..|.:..
  Fly   816 PSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVT 880

  Rat   871 TAAEQGGRNHLITKRDLSLSEGDVHTLGCGTAQCLQI-------TCQVGRLDRGKSA-------- 920
            |....|....:||:...|.   |:||.| ...|.:::       |..:.|..|...|
  Fly   881 TTLSGGLERTVITQNRQSY---DIHTSG-HVHQTMEVLDTSMVATASMSRKRRDLKALTANREQY 941

  Rat   921 --ILYVKSL-LWTETFMNK---------------------------------ENQNHSYSLKSSA 949
              |..||:. |.::.|..|                                 .|.|..||:..:.
  Fly   942 ARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNE 1006

  Rat   950 SFNIIEFPYK------NLPIEDLFNSTLVTTNITWGIQP------APMPVPVWVIILAVLAGLLL 1002
            ...|:..|::      :|.::...:.|..:.:|...|:|      ....:|:|:||::|:.||||
  Fly  1007 VNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEPNIISKHQETGLPIWIIIVSVIGGLLL 1071

  Rat  1003 LAVLVFVMYRMGFFKRVRPPQEEQER-EQLQPHE------NGEGNS 1041
            |:.:.:::|:.|||.|.:  ::|.:| .|..|.|      |..||:
  Fly  1072 LSAISYLLYKFGFFNRTK--KDELDRLVQQNPVEPEAENLNSGGNN 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itgav	XP_038962373.1	Int_alpha	46..103	CDD:214549	19/58 (33%)
		WD40 repeat	126..183	CDD:293791	13/67 (19%)
		WD40 repeat	188..248	CDD:293791	15/81 (19%)
		VCBS	221..271	CDD:404411	13/52 (25%)
		Int_alpha	248..>288	CDD:214549	15/43 (35%)
		WD40 repeat	254..298	CDD:293791	14/47 (30%)
		Int_alpha	302..355	CDD:214549	17/52 (33%)
		WD40 repeat	307..362	CDD:293791	16/54 (30%)
		Int_alpha	367..421	CDD:214549	25/53 (47%)
		WD40 repeat	371..422	CDD:293791	22/50 (44%)
		Int_alpha	434..476	CDD:214549	17/41 (41%)
		Integrin_alpha2	467..909	CDD:400650	102/476 (21%)
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	19/58 (33%)
		FG-GAP	350..388	CDD:280083	15/41 (37%)
		Int_alpha	409..459	CDD:214549	25/52 (48%)
		Int_alpha	473..>515	CDD:214549	17/41 (41%)
		Integrin_alpha2	507..829	CDD:285619	84/379 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335693
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840