DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpn5 and PTP-ER

DIOPT Version :9

Sequence 1:	XP_038965611.1	Gene:	Ptpn5 / 29644	RGDID:	3448	Length:	613	Species:	Rattus norvegicus
Sequence 2:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster

Alignment Length:	1022	Identity:	213/1022 - (20%)
Similarity:	313/1022 - (30%)	Gaps:	489/1022 - (47%)

- Green bases have known domain annotations that are detailed below.

  Rat     2 CTSSSSSLSSSSSSLTKESGDRMAQWSEKESQAADDSKGGTLDMCCSKRLLGWQHGPPVGDQIPG 66
            |:|::.|...|.:|||...||       .|.::|....||      ||..:|....|....:
  Fly   421 CSSTTQSSLDSDASLTPSLGD-------FELKSACSVDGG------SKFGIGASLAPRSAHK--- 469

  Rat    67 QDKLLSKKRSTEDSKGLPQPVEM-------GGLDEGEGLPSKQRELPPPPP-----SPPSEPAQK 119
            .::||..  |:.:.|.||:.:.:       ||..|.   |.||:.:..|.|     :..|..:..
  Fly   470 HNQLLHS--SSTNLKTLPECLTLVEFSSSGGGPKES---PFKQKSMDLPMPTLQAKTTVSTSSMN 529

  Rat   120 LPPQGAGSHSLTVRSSLCLFAASQLLLACGVLWLSGHGHSWLQTTTDLIFSSLTVLN-------- 176
            |..:...:||||:          .|..:||.|..||..||  ..:...|.:|.:..|
  Fly   530 LLQRRGSNHSLTL----------NLHSSCGNLMNSGLSHS--NYSLGSILNSKSSCNLDAGTASQ 582

  Rat   177 ----HLGPAAWLGSGTWGTPSLLL-----VSLTVSLGIITTLVWHLLKTPPEPPVPLPPEDRRQS 232
                .|..:..|||.......|..     .|:|:..|..||....|              :..|.
  Fly   583 IRADQLPQSHLLGSSQGSRQGLFRRRGSNHSITLKTGHTTTSCGDL--------------NSMQQ 633

  Rat   233 VSRQPSFTYSEWMEEKVEDDFLDLDAVPETPVFDCVMDIKPEA------DPTSLTVKSMGLQERR 291
            :.:|.:...:|....                     ::::..:      ..:::.....||.|||
  Fly   634 LQQQQAMLSAEKYNR---------------------LNMRTNSTGSGSGSGSNVPTPKRGLLERR 677

  Rat   292 GSNVSLTLDM------------------------CTPGC------------------------NE 308
            |||.||||:|                        |:  |                        ::
  Fly   678 GSNQSLTLNMGSILGGAAGTEIQMTDIVQPKVTVCS--CAAANQAPHQRKFFSTENLNSSKANSQ 740

  Rat   309 EGFGYLV---------SPREESAHE---------------------------------------Y 325
            :.||.:.         :|:::|..|                                       .
  Fly   741 KFFGQVCFGSASDLQPNPQQDSVREDQAIGATCTCAGTVRNIMTRPLSPQTTSEEFKIYLASIQM 805

  Rat   326 LLSASRVLRAEEL--------HEKALDPFLLQ--------AEFFEIPMNFVDP------------ 362
            |.|||..|...:|        |....:..:::        |...|.|.:.|.|
  Fly   806 LQSASNPLNQFDLIRLNYVFDHSYQTNRNIIEQPPVLGSNARDVETPTDMVPPSSEDSELLASYQ 870

  Rat   363 --------------------------KEY-DIP----------GLVRKNRYKTILPNPHSRVRLT 390
                                      ||: |:|          |...||||||||||.:|||.|.
  Fly   871 TVVSRMAQPIPELKENEQKRIFRDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLE 935

  Rat   391 SPDPEDPLSS------------------YINANYIRGYNGEEKVYIATQGPIVSTVADFWRMVWQ 437
            |...|  |:|                  |||||||:|.:...|.|:|||||:.:|:.:||.|::|
  Fly   936 SESSE--LTSLLGEIKRTSSVTASEDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQ 998

  Rat   438 --------------------ERTPI-------IVMITNIEEMN-EKCTEYWPEE----------- 463
                                :|..|       |||:||..|.| :||..|:|.|
  Fly   999 NTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKC 1063

  Rat   464 ------------------------QVV-------------HDGVE---ITVQ------------- 475
                                    .||             |.|||   :|::
  Fly  1064 EVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSF 1128

  Rat   476 ------KVIHTEDYRLRLI----------SLRRGTEERGLKHYWFTSWPDQKTPDRAPPLL---- 520
                  .::....|.:|.:          |.....::....|||:..|||..:|.....||
  Fly  1129 FLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCL 1193

  Rat   521 ------------------------HLVREVEEAAQQEGPHC-SPI-IVHCSAGIGRTGCFIA--- 556
                                    ||..:..|..||:..:. .|: ::||||||||||||.|
  Fly  1194 HVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILN 1258

  Rat   557 ------------------------------------TSICCQQLRR----------EGV------ 569
                                                :|..|..:|.          |.|
  Fly  1259 AVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSF 1323

  Rat   570 ----------VDILKTTCQLRQDRGGMIQTCEQYQFVHHAMSLYEKQ 606
                      ||:|...|.||..||||:|..|||:.:|.|:.||.|:
  Fly  1324 DRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAICLYLKR 1370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpn5	XP_038965611.1	PTPc-N5	346..603	CDD:350461	121/534 (23%)
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	110/449 (24%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	110/448 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3506
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.910