Protein Alignment Sv2c and CG31103

DIOPT Version :9

• Sequence 1: NP_113781.1
• Gene: Sv2c / 29643
• RGDID: 619718
• Length: 727
• Species: Rattus norvegicus
• Sequence 2: NP_001097914.1
• Gene: CG31103 / 43030
• FlyBaseID: FBgn0051103
• Length: 506
• Species: Drosophila melanogaster
• Alignment Length: 593
• Identity: 122/593 - (20%)
• Similarity: 226/593 - (38%)
• Gaps: 136/593 - (22%)

  Rat   138 YELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMM 202
            |::::::.|:|:.||.|..|.|:..:........:..::.:::.:.....:..|.:.:....|:.
  Fly    17 YDMVLEKIGYGKTQWVLLLVSGLLTITSVAAQQAMSIIVIASQCEFETTQAEKGVMMAASVTGIF 81

  Rat   203 VGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLLCRLLSGFGIGGAIPTVFSYFA 267
            :..:.||.::|.:||::.||.....:....|:..||.....|.:..||.|..:|.....:::|.:
  Fly    82 LSTYIWGYISDDIGRRRVLLYGNFASNALQFVLMFVTSVWLFNIINLLVGISVGAVSAALYAYLS 146

  Rat   268 EVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVS 332
            |......|...:::..||..:..||..|.||.::.. .|:.:||. :.|..||:.::|..||...
  Fly   147 EFNIPRHRAVAINYSTMFVSVTAIYVPATAWLVLSS-NWAITMGD-FVFRPWRLLLLVSLLPGFI 209

  Rat   333 SVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIES 397
            ..:.|.:.||||:|||...|::||                 .|.|..::|....|.|.:::..:.
  Fly   210 GGLILLYYPESPKFLLSQEKNNEA-----------------IEAVAWISKFNRGKSIQQVLSCDE 257

  Rat   398 DTGTWYRRCFVRIRTELYGIWLTFMRC------FNYPVRENTIKLTIVWFTLSFGYYGLSVWFPD 456
            .|..........:..|..|..:....|      |:.|...|.|...:..|.:.|...|:.:|||:
  Fly   258 FTLKSEDPVGENLLGESQGCGILSKICRATIPLFHKPHGFNFILCNLALFGMFFSSNGMQLWFPE 322

  Rat   457 VIKHLQSDEYALLTRNVQKDKYANFSINFTMENQVHTGMEYDNGRFLGVKFKSVTFKDSVFKSCT 521
            ::.....                       .||...|..|     .|.|..:.....:::  .||
  Fly   323 IVNRSSG-----------------------AENNSSTVCE-----ILSVPVEQPNVTETL--DCT 357

  Rat   522 FDDVTSVNTYFKNCTFIDTLFENTDFEPYKFIDSEFQNCSFLHNKTGCQITFDDDYSAYWIYFVN 586
             |.::|.       |:||.|                                          .|.
  Fly   358 -DPISSK-------TYIDNL------------------------------------------VVG 372

  Rat   587 FLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLY---NGLTI 648
            |    |.|.|..:..|:::.:||..:|..::.::.:|...|.|..|.:.::.:.|||   .||:|
  Fly   373 F----AFLIGFSIQGLILNPLGRKNVLLAALAVATLSGVLLHFMESPTGVLVLFCLYILLPGLSI 433

  Rat   649 SAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKAIPILL---------- 703
            |.   :....|:|.||..|:....|    |.:...||      :::.|..:.::|
  Fly   434 SI---MIGAIVDLVPTHLRSKAVSF----CMSLGRLG------IIAATNLMGVMLQPYCNTTFAM 485

  Rat   704 -ASTVLVC 710
             ..|::||
  Fly   486 FTCTLIVC 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sv2c	NP_113781.1	synapt_SV2	1..727	CDD:130366	122/593 (21%)
		Interaction with SYT1. /evidence=ECO:0000269|PubMed:15866046	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..120
		MFS	155..719	CDD:119392	116/576 (20%)
		Pentapeptide_3	507..561	CDD:290309	8/53 (15%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269|PubMed:16543415, ECO:0000269|PubMed:27294781	529..566		4/36 (11%)
CG31103	NP_001097914.1	2A0115	29..475	CDD:273327	115/561 (20%)
		MFS	34..>189	CDD:119392	30/155 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208328at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920