DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gria4 and KaiR1D

DIOPT Version :9

Sequence 1:	NP_001106655.1	Gene:	Gria4 / 29629	RGDID:	61863	Length:	902	Species:	Rattus norvegicus
Sequence 2:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	874	Identity:	346/874 - (39%)
Similarity:	511/874 - (58%)	Gaps:	82/874 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat    22 AFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAP-FNLVPHVDNIETANSFAVTNAFCS 85
            :.|..::|||||....|.:..|||.|:  ...:.:.|..| ..||..::.|...:||......|.
  Fly    25 SLPDIIKIGGLFHPADDHQELAFRQAV--DRINADRSILPRSKLVAQIERISPFDSFHAGKRVCG 87

  Rat    86 QYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLR------------PSL 138
            ..:.||.||||.....:...:.|.|..:.|..:        |:::..:||            .:|
  Fly    88 LLNIGVAAIFGPQSSHTASHVQSICDNMEIPHL--------ENRWDYRLRRESCLVNLYPHPNTL 144

  Rat   139 RGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDR 203
            ..|.:.::.|:.|..|..:|:.:.|...||.:::..|...:.::...:.:..|  ||.||:::..
  Fly   145 SKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLSDSGD--YRPLLKQIKN 207

  Rat   204 RQEKKFVIDCEIERLQNILEQIVSVGKHVKGYH-YIIANLGFKDISLERFIHGGANVTGFQLVDF 267
            ..|...|:||..||:..:|:|...:|. :..|| |::.:|....::|:.|.:||.|:|||:|:
  Fly   208 SAEAHIVLDCSTERIHEVLKQAQQIGM-MSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLI-- 269

  Rat   268 NTPMVTKLMDRWKKLDQREYPGSE--TPPKYTSALTYDGVLVMAETFRSL-RRQKIDISRRGNAG 329
            |..:|:.::.:| .:|::....|.  |..:..:||.||.|.:.|:....| ..|:|||......|
  Fly   270 NEKIVSDVVRQW-SIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDG 333

  Rat   330 DCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMD 394
            .      :.|..|..:...:|.|.::|||..::|||.|.|.::.:|:.||...|.||:|.||
  Fly   334 Q------STWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWN--- 389

  Rat   395 KLVLIQDMPTLGNDT-----------AAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCV 448
                 ..:|...|.|           |.::|:|:|||||:.:||.|.|::.....|||::|||.|
  Fly   390 -----STLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAV 449

  Rat   449 DLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDF 513
            ||..||:|.:|..|||.:||||.||:.:..|..||||:.||:..:|::|||.||||..||:.:||
  Fly   450 DLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDF 514

  Rat   514 SKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW----- 573
            :.|||:||:||:.:||.|..|.:||||.||:.::|:.:..||:||||:||::::|:||||
  Fly   515 TTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTD 579

  Rat   574 -HTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISS 637
             |.|:.|           ::|.:.|.:||::|:.||||||..|::||.|:|.|:|||||||:|||
  Fly   580 AHGEKVE-----------SQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISS 633

  Rat   638 YTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPS 702
            ||||||||||||||.|||||||||||||.|.||.|..|||..|||.|||:.|::||::|.||.||
  Fly   634 YTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPS 698

  Rat   703 VFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRNA 767
            |||.:..|||.||.|.||.:|||:|||..||:.:|. |:..:|||.||:|.||:|||..|..|.|
  Fly   699 VFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATPPNSPYRTA 762

  Rat   768 VNLAVLKLNEQGLLDKLKNKWWYDK---GECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAM 829
            :|..:|||.|:|.|..||.|||.:|   |:|......|....:.|.|:||.|||.:|:||:|:|.
  Fly   763 INSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVAC 827

  Rat   830 LVALIEFCYKSRAEAKRMKLTFSEAIRNK 858
            ::|:.||.:|||..|...:|:   ||.|:
  Fly   828 VIAVCEFVWKSRKVAVEERLS---AILNE 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gria4	NP_001106655.1	PBP1_iGluR_AMPA_GluR4	28..398	CDD:107383	106/386 (27%)
		ANF_receptor	39..380	CDD:279440	93/357 (26%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	210/389 (54%)
		Lig_chan	546..825	CDD:278489	152/287 (53%)
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	107/395 (27%)
		ANF_receptor	42..378	CDD:279440	93/357 (26%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	207/381 (54%)
		Lig_chan	547..823	CDD:278489	152/287 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820