DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gria4 and Ir8a

DIOPT Version :9

Sequence 1:	NP_001106655.1	Gene:	Gria4 / 29629	RGDID:	61863	Length:	902	Species:	Rattus norvegicus
Sequence 2:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	879	Identity:	206/879 - (23%)
Similarity:	351/879 - (39%)	Gaps:	231/879 - (26%)

- Green bases have known domain annotations that are detailed below.

  Rat   191 DVSYRQLLEELDRRQEKKFVIDCEIE-------------RLQNILEQIVSVGKHV---------- 232
            |.....:|:|||..:     :|.:::             .:|...|.:.:||...
  Fly    35 DTDIAMVLKELDALR-----LDVKVDDTTLTLTRSEDGLDMQRFCEILSTVGASAVIDLTYSHWE 94

  Rat   233 KGYHYIIANLGFKDISLERFIHGGANVTGFQLVDF-------NTPMV-TKLMDRWKKLDQR--EY 287
            :||: ::.:||...:.|||.:....::.|    ||       |..|| ....|..:.:.|.  .|
  Fly    95 EGYN-LVRSLGIGYVRLERIMRPFLDMFG----DFMRQKRANNVAMVFMNARDAVEAMQQMLVGY 154

  Rat   288 P-------GSETPP---------KYTSALTYDGVLVMAETFRSL--RRQKIDISR---------- 324
            |       .|:|.|         ....|.||..:...|.....:  :.||.|:.:
  Fly   155 PFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFVFL 219

  Rat   325 ---------RGNAGDC---LANPAA-----PW-----GQGIDMERTLKQVRIQGLTGNVQ----- 362
                     |..|..|   ..||.|     |.     |.|..|:|.:....::.|....|
  Fly   220 DTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGY 284

  Rat   363 ------------------------------------FDHYGRRVNYTMDVFELKSTGPR-----K 386
                                                |..|...:.:..|.|:....|..     .
  Fly   285 PLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNIS 349

  Rat   387 VGY-------------WNDMDKLVLIQDMPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFE 438
            .||             |:.:.::.|:       |:|.:...|...:.|....|:...::.....|
  Fly   350 AGYYSSEHEAKTDLAAWSSVGEMRLL-------NETISPARRFFRIGTAESIPWSYLRREEGTGE 407

  Rat   439 ------GNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIA 497
                  |...:||||:|....:::.:..:::|.....|..|..: :...|:|:||:||.|:.:.|
  Fly   408 LIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELN-ELGEWDGVVGDLVRGETDFA 471

  Rat   498 IAPLTITLVREEVIDFSKPFM-SLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVV 561
            ||.|.:...|||||||..|:. ..||||.|:||.: :..:|.|:..|..|:|:.||.|.:|.:::
  Fly   472 IAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVR-RTSLFKFMTVLRLEVWLSIVAALVGTAIM 535

  Rat   562 LFLVSRFSPYEWHTEEPEDGKEGPSDQP--PNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVG 624
            ::.:.::|||        ..:......|  ..||.:..|.||:|.:|..||...:|:::|||::.
  Fly   536 IWFMDKYSPY--------SSRNNRQAYPYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLV 592

  Rat   625 GVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIA-- 687
            ..:|.|.:::::::|||||||||||||.:|::|.|.||:|:.|.|..:....|.::|...|.|
  Fly   593 AAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAED 657

  Rat   688 -VYE----------------KMWTY------------MRSAEPSVFTRTTAEGVARV-RKSKGKF 722
             :|.                ::|.|            :.|::|   .....||.|.| ......:
  Fly   658 TLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEGFANVDAHENADY 719

  Rat   723 AFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRNAVNLAVLKLNEQGLLDKLKNK 787
            ||:.:|...:| |..:.|:..:||.....:.|.||..:||.|.:.::.|:|:|.:....::||.|
  Fly   720 AFIHDSAEIKY-EITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAK 783

  Rat   788 WWYDKG--ECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLT 850
            :|....  .|..    |:|: ..::|.::.|||...:.||.|||:...:|..|..:.: ..:::|
  Fly   784 YWNQSNLPNCPL----SEDQ-EGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQ-NALEIT 842

  Rat   851 FSEAIRNKARLSITGSVGENGRVLTPDCPKAVHT 884
               .:|     .:..|.|..|...|.. |.|..|
  Fly   843 ---QVR-----PVNDSSGSGGNSSTAP-PTATST 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gria4	NP_001106655.1	PBP1_iGluR_AMPA_GluR4	28..398	CDD:107383	58/348 (17%)
		ANF_receptor	39..380	CDD:279440	54/312 (17%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	122/423 (29%)
		Lig_chan	546..825	CDD:278489	87/314 (28%)
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	121/416 (29%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	87/314 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910