Protein Alignment Gria4 and Ir8a

DIOPT Version :10

• Sequence 1: NP_058959.2
• Gene: Gria4 / 29629
• RGDID: 61863
• Length: 902
• Species: Rattus norvegicus
• Sequence 2: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Alignment Length: 877
• Identity: 206/877 - (23%)
• Similarity: 350/877 - (39%)
• Gaps: 227/877 - (25%)

  Rat   191 DVSYRQLLEELDRRQEKKFVIDCEIE-------------RLQNILEQIVSVGKHV---------- 232
            |.....:|:|||..:     :|.:::             .:|...|.:.:||...
  Fly    35 DTDIAMVLKELDALR-----LDVKVDDTTLTLTRSEDGLDMQRFCEILSTVGASAVIDLTYSHWE 94

  Rat   233 KGYHYIIANLGFKDISLERFIHGGANVTGFQLVDF-------NTPMV-TKLMDRWKKLDQR--EY 287
            :||: ::.:||...:.|||.:....::.|    ||       |..|| ....|..:.:.|.  .|
  Fly    95 EGYN-LVRSLGIGYVRLERIMRPFLDMFG----DFMRQKRANNVAMVFMNARDAVEAMQQMLVGY 154

  Rat   288 P-------GSETPP---------KYTSALTYDGVLVMAETFRSL--RRQKIDISR---------- 324
            |       .|:|.|         ....|.||..:...|.....:  :.||.|:.:
  Fly   155 PFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFVFL 219

  Rat   325 ---------RGNAGDC---LANPAA-----PW-----GQGIDMERTLKQVRIQGLTGNVQ----- 362
                     |..|..|   ..||.|     |.     |.|..|:|.:....::.|....|
  Fly   220 DTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGY 284

  Rat   363 ------------------------------------FDHYGRRVNYTMDVFELKSTGPR-----K 386
                                                |..|...:.:..|.|:....|..     .
  Fly   285 PLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNIS 349

  Rat   387 VGY-------------WNDMDKLVLIQDMPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFE 438
            .||             |:.:.::.|:       |:|.:...|...:.|....|:...::.....|
  Fly   350 AGYYSSEHEAKTDLAAWSSVGEMRLL-------NETISPARRFFRIGTAESIPWSYLRREEGTGE 407

  Rat   439 ------GNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIA 497
                  |...:||||:|....:::.:..:::|.....|..|..: :...|:|:||:||.|:.:.|
  Fly   408 LIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELN-ELGEWDGVVGDLVRGETDFA 471

  Rat   498 IAPLTITLVREEVIDFSKPFM-SLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVV 561
            ||.|.:...|||||||..|:. ..||||.|:||.: :..:|.|:..|..|:|:.||.|.:|.:::
  Fly   472 IAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVR-RTSLFKFMTVLRLEVWLSIVAALVGTAIM 535

  Rat   562 LFLVSRFSPYEWHTEEPEDGKEGPSDQP--PNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVG 624
            ::.:.::|||        ..:......|  ..||.:..|.||:|.:|..||...:|:::|||::.
  Fly   536 IWFMDKYSPY--------SSRNNRQAYPYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLV 592

  Rat   625 GVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIA-- 687
            ..:|.|.:::::::|||||||||||||.:|::|.|.||:|:.|.|..:....|.::|...|.|
  Fly   593 AAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAED 657

  Rat   688 -VYE----------------KMWTY------------MRSAEPSVFTRTTAEGVARV-RKSKGKF 722
             :|.                ::|.|            :.|::|   .....||.|.| ......:
  Fly   658 TLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEGFANVDAHENADY 719

  Rat   723 AFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNK 787
            ||:.:|...:| |..:.|:..:||.....:.|.||..:||.|...::.|:|:|.:....::||.|
  Fly   720 AFIHDSAEIKY-EITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAK 783

  Rat   788 WWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFS 852
            :|.....  |....|:|: ..::|.::.|||...:.||.|||:...:|..|..:.: ..:::|
  Fly   784 YWNQSNL--PNCPLSEDQ-EGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQ-NALEIT-- 842

  Rat   853 EAIRNKARLSITGSVGENGRVLTPDCPKAVHT 884
             .:|     .:..|.|..|...|.. |.|..|
  Fly   843 -QVR-----PVNDSSGSGGNSSTAP-PTATST 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria4	NP_058959.2	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	59/350 (17%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	122/421 (29%)
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	121/416 (29%)