DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt2b37 and Ugt36A1

DIOPT Version :9

Sequence 1:	NP_001007265.4	Gene:	Ugt2b37 / 29623	RGDID:	3937	Length:	530	Species:	Rattus norvegicus
Sequence 2:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	564	Identity:	144/564 - (25%)
Similarity:	260/564 - (46%)	Gaps:	85/564 - (15%)

- Green bases have known domain annotations that are detailed below.

  Rat    17 CLRSA----------------KCGKVL-VWP-MEFSHWMNIKTILDELVQRGHEVTVLKPSAYYV 63
            ||||.                ..|.:| |:| ..|||:..:..||:||..|||::||:.    ||
  Fly     4 CLRSGVLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVIS----YV 64

  Rat    64 LDPKKSPDLKFETFPTSVSKDELEKYFIKLVDAWTYELQRDTCLSFSPLLQN--------MMDEF 120
            .:|:......:|....|...::                |..|.::..||.::        ::.|:
  Fly    65 KNPQAGAYPNYEELLISAPGED----------------QSSTTINLVPLTEHTPTRSLGVLIREY 113

  Rat   121 SDYY---LSVCKDAVSNKQLMAKLQESK---FDVLLSDPV-AACGELIAEVLHIPF--LYSLRAS 176
            .|.:   ...|:...::..:...::..:   :|:||::.. :.|...:|::|::|.  |.:....
  Fly   114 VDLHEEGQKTCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALM 178

  Rat   177 PGHKIEKSSGRFILP--PSYVPVILSGLGGQMTFIDRVKNMI--CMLYFDFWFHMFNAKNWDPFY 237
            |.:     ..|..||  |:::.....|..||:.:.:|:.|.:  .:|.|.:.:|...|.|  ...
  Fly   179 PYY-----YDRIDLPDTPAFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADN--ELV 236

  Rat   238 TEILGRPTTLAETMGKAEMWLI-RSYWDLEFPHPTLPNVDYIGGLQC--KPAKPLPKDIEDFVQS 299
            .:.||....:.|.......::. ..::.|....|.......|||:..  |..:.||::|.:|:..
  Fly   237 RKYLGVEVDVEEVARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQ 301

  Rat   300 SGEHGVVVFSLGSMV--SSMTEEKANAVAWALAQIPQKVLWKFDG-KIPATLGPNTRVYKWLPQN 361
            |.| ||:..|.||||  ||:.|:|.:|:...|...|.|::||::. :.|.|........||.||.
  Fly   302 SAE-GVIFISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQL 365

  Rat   362 DLLGHPKTKAFVTHGGANGVYEAIYHGIPMIGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDL 426
            .||.|||.|.|.:|||..|..|:::.|.|::..|::|:|..|...:..:|..:.|:.:.::..:|
  Fly   366 ALLCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNL 430

  Rat   427 FNALKEVINNPFYKKNAMWLSTIHHDQPMKPLDKAIFWIEYVMRHK--RAKHLRPLGHNLPWYQY 489
            ..||.|:..|. |.:.::.:|.:.:::...||:.||:.:|:|:.:.  .|:.|:..|..|..:.|
  Fly   431 KKALAELSKNS-YAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVY 494

  Rat   490 HSLDVIGFLLACLAVIAALAVKCFL-------FIYRFFAKKQKK 526
            ||||.:..:|  |.:|..:.|.|:|       ..::...||.|:
  Fly   495 HSLDSVALIL--LPLILLILVLCYLCKRNPSKLAHKKVGKKPKR 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt2b37	NP_001007265.4	UDPGT	24..527	CDD:278624	140/541 (26%)
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	122/495 (25%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	127/491 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910