DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ptprm and Lar

DIOPT Version :9

Sequence 1:XP_038939045.1 Gene:Ptprm / 29616 RGDID:620776 Length:1531 Species:Rattus norvegicus
Sequence 2:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster


Alignment Length:1860 Identity:503/1860 - (27%)
Similarity:735/1860 - (39%) Gaps:551/1860 - (29%)


- Green bases have known domain annotations that are detailed below.


  Rat    16 LMLAFLVRAAEICAFVSGFSVYREY-----------RGCLFEEPYS---TCGYSQADDDDFNW-- 64
            :.:.::|||         .|.|.||           ||     |.|   ||     ...||::  
  Fly   373 ITMYYVVRA---------LSPYTEYEFYVIAVNNIGRG-----PPSAPATC-----TTGDFSFGG 418

  Rat    65 ---------EQVNTLTKPT-----SDPWMPSG-----SFMLVNTSGKPEGQ-RAHLL----LPQL 105
                     .||.||:..|     ..|..|:|     .......|.:||.. .:.::    |..:
  Fly   419 TKMESAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTV 483

  Rat   106 KENDTHCIDFHYFVSSKSNAAPGLLNVYVKVNNGPLGNPI-----WNISGDP------------- 152
            .|...|.|   |.|.         :..|..:..||:..|:     ..:...|             
  Fly   484 SELTPHAI---YTVR---------VQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAV 536

  Rat   153 ----TRTWHRAELAV--STFWPNFYQVIFEVVTSGHQGYLAIDEVKVL----------------- 194
                |:..|.:|..|  ..:|.:.|      ....|...::..|...|                 
  Fly   537 TLQWTKPTHSSENIVHYELYWNDTY------ANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARS 595

  Rat   195 --GHPCTRTPHFLRI-------QNVEVNAGQFATFQCSAI--------GRTVAGDRLWLQ-GIDV 241
              |...|..|..:|.       :|:...|....|...|.:        ||.:.....::: |.:.
  Fly   596 QRGEGATTPPIPVRTKQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGRED 660

  Rat   242 RDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMI--RTEGGVGISNYAELVVKEPPVPIAPP 304
            .:|....:.:||.        |::..||.. :|:..:  .|..|.|..::..::..:..|| ..|
  Fly   661 DEATTMTLNMTSI--------VLDELKRWT-EYKIWVLAGTSVGDGPRSHPIILRTQEDVP-GDP 715

  Rat   305 QLASVGATYL--------W---IQLNANSINGDGPIVAREVEYCTASGSWNDR---QPVDSTSYK 355
            |  .|.||.|        |   ::.:.|.|.....|.|:|:. ....|..|:.   ..||:..:.
  Fly   716 Q--DVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELR-DEGKGFLNEPFKFDVVDTLEFN 777

  Rat   356 IGHLDPDTEYEISV-LLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQ----ITIR 415
            :..|.|||:|.|.| .|||.|:|...:   |:..:|....|:|....|:::|   |:    |.:.
  Fly   778 VTGLQPDTKYSIQVAALTRKGDGDRSA---AIVVKTPGGVPVRPTVSLKIME---REPIVSIELE 836

  Rat   416 WE-PF-------GY---------------------------NVTRCHSYNLTVRYCYQVG-GQEQ 444
            || |.       ||                           |:.|...|...|.....:| |||.
  Fly   837 WERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQET 901

  Rat   445 VR----EE---------------------VSWD-MDNSHPQHTIT------------NLSPYTNV 471
            |:    .|                     |:|| ....|....||            .|....|:
  Fly   902 VKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGSERNM 966

  Rat   472 SV-KLILMNPEGRKE----------------SQELTVQTDEDLPGAVPTESIQGSAFEEKIFLQW 519
            :: |.:..|.|...|                |.:|.|:|:.|: |..|. |:|..|..|:....|
  Fly   967 TLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDM-GRAPM-SLQAEATSEQTAEIW 1029

  Rat   520 REPTQTYGVITLYEITY--KAVSSFD----------PEIDL-----------------SNQSGRV 555
            .||..:.|.:..|:|.|  .||...|          ...||                 .|..||:
  Fly  1030 WEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLGRL 1094

  Rat   556 SKLGN-----------------ETHFLFFG----------------------------------- 568
            |:...                 .||.:...                                   
  Fly  1095 SEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVP 1159

  Rat   569 -----------------LYPGTTYSFTIRASTAK-GFGPPATNQFTTKISAPS-MPAYEFETPLN 614
                             |.|.|||:..:.|..:. .:.||.....||:::||. |...:|...:|
  Fly  1160 KREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYGVVN 1224

  Rat   615 QTDNTVTVLLKPAQSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASILNSQY---- 675
            ..:  :.|:|..|.....|:|.|.:||..|......|         :|..|....:|..:.    
  Fly  1225 GEE--ILVILPQASEEYGPISHYYLVVVPEDKSNLHK---------IPDQFLTDDLLPGRNKPER 1278

  Rat   676 ----YFAAEFPADSLQAAQPFT--IGDNKTYNGYWNTPLLPHKSYRIYYQAASRANGETKIDCVR 734
                |.||:||..|:    |||  :|....|:.:.|..|...|.|||:.:|.             
  Fly  1279 PNAPYIAAKFPQRSI----PFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAV------------- 1326

  Rat   735 VATKAAIIVTQLTTPY-------IRIAPAAGDGQLTGAVTPKPVPEPEKGTDHT---VKIAGVIA 789
            |.|....:.|  ::|:       :|.||   .|:......|....|||...:..   .:|..|:.
  Fly  1327 VDTPQKHLYT--SSPFSEFLSLDMREAP---PGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVL 1386

  Rat   790 GILLFVIIF---LGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMD 851
            .:::...|.   |.|:.|:|:|:...|..:..:.||..|.          |:.|..         
  Fly  1387 PLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMA----------ADLGAG--------- 1432

  Rat   852 THNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTAILGAQQTRLSVPINDETHTMASDTSS 916
                                           |.|..|     ....||    |.:|..|.|    
  Fly  1433 -------------------------------PTPSDP-----VDMRRL----NFQTPGMIS---- 1453

  Rat   917 LAQPHTYKKREAADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAK 981
                                  ||.|.:::...||.::|..:...|.:||||...||...||::.
  Fly  1454 ----------------------HPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSN 1496

  Rat   982 KDENRMKNRYGNIIAYDHSRVRLQMLEGDNSSDYINGNYIDGYHRPNHYIATQGPMQETVYDFWR 1046
            .:.|:.||||.|:.|||||||:|..:||...|||||.||.|||.:.|.|:|||||:|||..||||
  Fly  1497 LEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWR 1561

  Rat  1047 MVWYENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIDTELLAEYVIRTFAVEKGGAG 1110
            |.|...||:|:|:|.|.|..|:||.:|||. .||.|..|.||:.:|:.||.|.||||        
  Fly  1562 MCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTF-------- 1618

  Rat  1111 GEANCSPSREVPQRGIHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPNAGPLVVHCS 1175
                     ::.::|.::.|||:|..||.|||||||.|....|.|:|:.::.:||.:||::||||
  Fly  1619 ---------QLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCS 1674

  Rat  1176 AGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTS 1240
            ||.|||||:||||.||:..:.|.::|||..|..||::|..|||||:||:|||||||||.:||.|.
  Fly  1675 AGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTE 1739

  Rat  1241 IPASQVRSLYYDMNKL---DPQTNSSQIKEEFRTLNMVTPTLRVEDCS---IALLPRNHEKNRCM 1299
            :||   |:|:..:.||   :|....|.::.||:.|:.|.     .|.|   .|.||.|..|||.:
  Fly  1740 VPA---RNLHTHLQKLLITEPGETISGMEVEFKKLSNVK-----MDSSKFVTANLPCNKHKNRLV 1796

  Rat  1300 DILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVV 1363
            .|||.:....:|..|.| |.|:|:||:.:|.|:..||:|..|.|:.:..:||||::.:::.|.||
  Fly  1797 HILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVV 1861

  Rat  1364 MLNDVDP--TQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNASRPQDG-HRMVQQF 1425
            ||..:..  .:.|.||||.....|:   |...|....|.::.....|.:..:..:|| .|.|:||
  Fly  1862 MLTKLKEMGREKCFQYWPHERSVRY---QYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQF 1923

  Rat  1426 QFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1490
            ||:.|| .:..|.|...|:..|.||.|.:|:: |.:|...|||..|.||||.|..:|||.|.:::
  Fly  1924 QFIDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPITVHCSAGVGRSGVFITLSIVLERMQY 1986

  Rat  1491 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNA 1530
            :..:|||..|:.||:.:|.||...|||.|||..|||||.:
  Fly  1987 EGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGS 2026

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtprmXP_038939045.1 FN3 298..377 CDD:214495 29/93 (31%)
FN3 399..493 CDD:238020 34/188 (18%)
fn3 515..590 CDD:394996 24/173 (14%)
R-PTPc-M-1 946..1235 CDD:350481 144/289 (50%)
R-PTPc-M-2 1321..1526 CDD:350483 78/207 (38%)
MAM 42..198 CDD:214533 39/227 (17%)
ig 208..290 CDD:395002 17/92 (18%)
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470 10/44 (23%)
FN3 423..514 CDD:238020 21/102 (21%)
FN3 520..610 CDD:238020 13/95 (14%)
FN3 616..707 CDD:238020 17/99 (17%)
FN3 712..810 CDD:238020 30/104 (29%)
FN3 832..907 CDD:238020 15/74 (20%)
FN3 914..1005 CDD:238020 15/90 (17%)
FN3 1012..1101 CDD:238020 21/89 (24%)
fn3 1106..1198 CDD:278470 8/91 (9%)
PTPc 1476..1731 CDD:214550 138/271 (51%)
PTPc 1503..1731 CDD:238006 128/244 (52%)
PTPc 1763..2022 CDD:214550 99/268 (37%)
PTPc 1791..2022 CDD:238006 89/235 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4228
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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