DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptprm and Ptp36E

DIOPT Version :9

Sequence 1:	XP_038939045.1	Gene:	Ptprm / 29616	RGDID:	620776	Length:	1531	Species:	Rattus norvegicus
Sequence 2:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	683	Identity:	208/683 - (30%)
Similarity:	345/683 - (50%)	Gaps:	73/683 - (10%)

- Green bases have known domain annotations that are detailed below.

  Rat   893 GAQQTRLSVPINDETHTMASDTSSLAQPHTYK--------------KREAAD--------VPYQT 935
            |..::|.|...:|.........:.::.|:|.|              |.||.|        :|...
  Fly    18 GKHRSRSSARYDDVEKQQRKSRAIVSIPNTIKLSMLNSGLLSFERIKLEARDENNSLSKTIPNGP 82

  Rat   936 GQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHS 1000
            ..:...:::.||.:....:       :|.|:::..:.:|.....|.|..|..||:....|.||::
  Fly    83 IDIRHFLKLCDLRRKFPVL-------YKLEFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYN 140

  Rat  1001 RVRLQMLEGDNSSDYINGNYIDGYHRPNHYIATQGPMQETVYDFWRMVWYENTASIIMVTNLVEV 1065
            ||.|:.:.|...|||:|.:|:|...:||.||.||||::|||..:|||||.||.::|:|:|...:.
  Fly   141 RVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDF 205

  Rat  1066 GRVKCCKYWPDDTEI---YKDIKVTLIDTELLAEYVIRTFAVEKGGAGGEANCSPSREVPQRGIH 1127
            .:|.|.:|||.:.|:   |.||.:.::..|.||.:.||||.:.|        .:..:||...
  Fly   206 AKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLYK--------MNEKQEVTDE--- 259

  Rat  1128 EIREIRQFHFTGWPDHGVPYHATGLLGFVRQVK-------SKSPPNAGPLVVHCSAGAGRTGCFI 1185
              |.|.|||:|.|..|..|: :..||.|.|:|:       .......||::||||.|.||:|.::
  Fly   260 --RLILQFHYTEWYSHSCPF-SNALLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDGGGRSGVYM 321

  Rat  1186 VIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSIPASQVRSLY 1250
            .||..|::||.|...:::..:::||..|..:|:..|||.||:|.:.|..:||.|..|.|::....
  Fly   322 SIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRL 386

  Rat  1251 YDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITID 1315
            ....:.:..|..::.:.|:..:...||...:.||:......|.||||.:..:|||...|:|.:..
  Fly   387 KAKARRNSGTKMNEYQAEYDQICKQTPRFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQ 451

  Rat  1316 GES-SNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVML-NDVDPTQLCPQYW 1378
            |.: ::|||:..:|.|.:|..:|||:.|:.:|:.:||.||.|..|::||:| .....:|..|.:|
  Fly   452 GNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQQYPSFW 516

  Rat  1379 P-ENGVHRHGPI-QVEFVSA-----------DLEEDIISRIFRIYNASRPQDGHRMVQQFQFLGW 1430
            | ::.:.::||: .|.:|.:           .:.:.|:|....:.....|.   |.||.||...|
  Fly   517 PNKSKMEKYGPVFSVHYVMSKSYTNIKQWEFKINKKIVSLTEMMAGVKAPT---RTVQLFQLTCW 578

  Rat  1431 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVD 1495
            ||....|.|..|.:.|:..|:.|:.:.:  .|...|...:|..|:|.:||.:...|.:.....||
  Fly   579 PMGHKVPSSTNSLVYLMNMVEIWRNKVD--YGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVD 641

  Rat  1496 VFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1528
            ||.||||:|.::|.:|:.:.:||:||::.|.|:
  Fly   642 VFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptprm	XP_038939045.1	FN3	298..377	CDD:214495
		FN3	399..493	CDD:238020
		fn3	515..590	CDD:394996
		R-PTPc-M-1	946..1235	CDD:350481	104/298 (35%)
		R-PTPc-M-2	1321..1526	CDD:350483	68/218 (31%)
		MAM	42..198	CDD:214533
		ig	208..290	CDD:395002
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	96/256 (38%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053	79/247 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000829
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.770