DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arhgap11a and cv-c

DIOPT Version :9

Sequence 1:	NP_001161996.1	Gene:	Arhgap11a / 296060	RGDID:	1309107	Length:	994	Species:	Rattus norvegicus
Sequence 2:	NP_001097786.1	Gene:	cv-c / 41749	FlyBaseID:	FBgn0285955	Length:	2351	Species:	Drosophila melanogaster

Alignment Length:	199	Identity:	59/199 - (29%)
Similarity:	90/199 - (45%)	Gaps:	39/199 - (19%)

- Green bases have known domain annotations that are detailed below.

  Rat    45 KIFGVPF--------NSLPHSVVPEYGHIPSFLVDACTSLKEHIHTEGLFRKSGSVIRLKALKSK 101
            |:||||.        .:||.:|...:..:....:|..          |:|||||...|:..|:.:
  Fly  1895 KVFGVPLLMILQRSGQTLPLAVRAAFRWLQLNALDQV----------GIFRKSGGKSRIMKLREQ 1949

  Rat   102 LDHGEACLSSALPC----------DVAGLLKQFFRELPEPVLPADLHE---ALFKAQQLGAEERN 153
            ::    ...|...|          |||.:|||:||||||.:|...:.|   |:|  |.|.||.|.
  Fly  1950 IE----VTDSTAECMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSETFVAIF--QHLPAEVRL 2008

  Rat   154 KATLLLSCLMADPTVDVLRYFFNFLKSVSLRASENKMDSSNLAVIFAPNLLQT--SEGHEKMSAN 216
            .|......|:.|...::|.....||..|:..:.:|:|.|:||.|..|.::..:  |.|...:||:
  Fly  2009 DAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFHSSISTGSASVSAS 2073

  Rat   217 TEKK 220
            ..:|
  Fly  2074 PRRK 2077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arhgap11a	NP_001161996.1	RhoGAP-ARHGAP11A	46..246	CDD:239859	58/198 (29%)
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937
		RhoGAP_DLC1	1893..2116	CDD:239840	59/199 (30%)
		SRPBCC	2148..2343	CDD:301327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910