DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P2ry2 and AstC-R1

DIOPT Version :9

Sequence 1:	NP_058951.2	Gene:	P2ry2 / 29597	RGDID:	62088	Length:	374	Species:	Rattus norvegicus
Sequence 2:	NP_649040.2	Gene:	AstC-R1 / 40020	FlyBaseID:	FBgn0036790	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	386	Identity:	97/386 - (25%)
Similarity:	166/386 - (43%)	Gaps:	69/386 - (17%)

- Green bases have known domain annotations that are detailed below.

  Rat    27 FNEDFKYVLLPVSYGVVCVLGLCLNVVALYIFLCRLKTWNASTTYMFHLAVSDSLYAASLPLLVY 91
            |.:.|..||    ||.||::||..|.:.:|:.|...|....:..|:.:|||:|..:...:|.|:
  Fly    75 FADLFTVVL----YGFVCIIGLFGNTLVIYVVLRFSKMQTVTNIYILNLAVADECFLIGIPFLL- 134

  Rat    92 YYAQGDHWPFSTVLCKLVRFLFYTNL--YCSILFLTCISVHRCLGVLRPLHSLSWGHARYARRVA 154
            |..:...|.|...:||  .::..|::  :.|.:||..:|..|.:.|..|:.|..:.....|:.|:
  Fly   135 YTMRICSWRFGEFMCK--AYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTLHIAKVVS 197

  Rat   155 AVVWVLVLACQAPVLYFVTTSVR--GTRITCH----DTSARELFSHFVAYSSVMLGLLFAVPFSI 213
            |:.|........||:.:.:|..:  |...:|:    |...:...:.|:.| :..||  ||.|...
  Fly   198 AIAWSTSAVLMLPVILYASTVEQEDGINYSCNIMWPDAYKKHSGTTFILY-TFFLG--FATPLCF 259

  Rat   214 ILVCYVLMARRLL----KPAYGTTGLPRAKRKSVRTIALVLAVFALCFLPFHVTRT--LYYSFRS 272
            ||..|.|:.|:|.    ||...:....||.||..|.:..|::|:.||:||..:::.  ::.:...
  Fly   260 ILSFYYLVIRKLRSVGPKPGTKSKEKRRAHRKVTRLVLTVISVYILCWLPHWISQVALIHSNPAQ 324

  Rat   273 LDLSCHTLNAINMAYKITRPLASANSCLDPVLY-FLAGQRLVRFAR----------DAKPATEP- 325
            .|||...:    :.:.:...|..:||.::|:|| ||:......|.:          :|:...||
  Fly   325 RDLSRLEI----LIFLLLGALVYSNSAVNPILYAFLSENFRKSFFKAFTCMNKQDINAQLQLEPS 385

  Rat   326 -----------------TPSPQARRKLGLHRPNRTDTVRKDLSISSDDSRRTESTPAGSET 369
                             |.:||....|.|:..|            ::.|..|.||....:|
  Fly   386 VFTKQGSKKRGGSKRLLTSNPQIPPLLPLNAGN------------NNSSTTTSSTTTAEKT 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P2ry2	NP_058951.2	7tmA_P2Y2	34..316	CDD:320495	80/296 (27%)
		TM helix 1	36..60	CDD:320495	8/23 (35%)
		TM helix 2	69..90	CDD:320495	6/20 (30%)
		TM helix 3	107..129	CDD:320495	5/23 (22%)
		TM helix 4	152..168	CDD:320495	3/15 (20%)
		TM helix 5	196..219	CDD:320495	8/22 (36%)
		TM helix 6	243..265	CDD:320495	7/21 (33%)
		TM helix 7	284..309	CDD:320495	8/25 (32%)
AstC-R1	NP_649040.2	7tm_4	88..368	CDD:304433	76/289 (26%)
AstC-R1	NP_649040.2	7tm_1	94..353	CDD:278431	68/268 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000