DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hes1 and cwo

DIOPT Version :9

Sequence 1:	NP_077336.3	Gene:	Hes1 / 29577	RGDID:	62081	Length:	281	Species:	Rattus norvegicus
Sequence 2:	NP_524775.1	Gene:	cwo / 44669	FlyBaseID:	FBgn0259938	Length:	698	Species:	Drosophila melanogaster

Alignment Length:	330	Identity:	76/330 - (23%)
Similarity:	111/330 - (33%)	Gaps:	120/330 - (36%)

- Green bases have known domain annotations that are detailed below.

  Rat    16 ATPASVNTTPDKPKTASEHRKSSKP------IMEKRRRARINESLSQLKTLILDALKKDSSRHSK 74
            :|.|:..:..|.........|:|:.      |:|||||.|:|..|:.|..||....::..  ..:
  Fly    38 STSATAYSEDDAEYATGRRNKTSRQDPLSHRIIEKRRRDRMNSCLADLSRLIPPQYQRKG--RGR 100

  Rat    75 LEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFL------STCEGVNT 133
            :||.:|:||.::||::||        |........||:|:.:||.|..:||      ..|.
  Fly   101 IEKTEIIEMAIRHLKHLQ--------SECQQKESDYRSGYMDCMKEAAKFLYDVHMQDFCH---- 153

  Rat   134 EVRTRLLGHL----------------ANCMTQINAMTYPGQAHPALQAPPPP-------PPSGPG 175
                ||||.|                .:|....|.....|..|   ||..||       ..:...
  Fly   154 ----RLLGRLQEHIDEMFKTDCYKSTRSCHMPDNVSASSGSPH---QAYHPPLCHLRDMLATSAS 211

  Rat   176 GPQH--------------------------APFAPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAA 214
            ..:|                          |..|.....|.:..|::|         .|.||..:
  Fly   212 DVEHSQDHNDVKDLSFRNHLNQLQRSQQAAAAAAVAAAAVAVANGSSP---------ASNAGVDS 267

  Rat   215 KV-------FGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTS---VGPNAVSPSSGSS 269
            ||       .||  ..||.|.                 :|..::.||::   .|.|:.|..|.||
  Fly   268 KVPLTNGGGTGG--APPAADN-----------------VPSNSTGSGSAAACAGGNSNSSGSNSS 313

  Rat   270 LTADS 274
            ..|.|
  Fly   314 NAASS 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hes1	NP_077336.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		6/33 (18%)
		bHLH-O_HES1_4	33..95	CDD:381465	23/67 (34%)
		Hairy_orange	110..148	CDD:400076	15/59 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..206		11/80 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..281		8/23 (35%)
		WRPW motif	276..279
cwo	NP_524775.1	HLH	66..118	CDD:306515	19/53 (36%)
cwo	NP_524775.1	ORANGE	126..168	CDD:128787	14/49 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334638
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740