Protein Alignment Hes1 and E(spl)m3-HLH

DIOPT Version :9

• Sequence 1: NP_077336.3
• Gene: Hes1 / 29577
• RGDID: 62081
• Length: 281
• Species: Rattus norvegicus
• Sequence 2: NP_524509.2
• Gene: E(spl)m3-HLH / 43156
• FlyBaseID: FBgn0002609
• Length: 224
• Species: Drosophila melanogaster
• Alignment Length: 261
• Identity: 68/261 - (26%)
• Similarity: 110/261 - (42%)
• Gaps: 60/261 - (22%)

  Rat    33 EHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNL-QRAQM 96
            ::||..||::|::||||||:.|..||.|:::.|:::....::||||||||:||.|:|.| ||..:
  Fly    10 QYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQRGGL 74

  Rat    97 ----------TAALSTDPSVLGKYRAGFSECMNEVTRFL---STCEGVNTEVRTRLLGHLANCMT 148
                      :...||..:.:..:|:|:....:::|:.|   ...:.:..::...|...|....|
  Fly    75 SLQGVVAGVGSPPTSTSTAHVESFRSGYVHAADQITQVLLQTQQTDEIGRKIMKFLSTRLIELQT 139

  Rat   149 QINAMTYPGQAHPALQAPPPPPPSGPGGPQHAPFAPPPPLVPIPGGAAPPPGSAPCKLGSQAGEA 213
            |:.......|.|...|.   |..||     ...|       |:.||..|...:|
  Fly   140 QLLQQQQQQQQHQQQQI---PQSSG-----RLAF-------PLLGGYGPAAAAA----------- 178

  Rat   214 AKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTADSMWRP 278
                               .|...:|..|...:...||..|.::...| |.||..|..::.:|||
  Fly   179 -------------------AISYSSFLTSKDELIDVTSVDGNALSETA-SVSSQESGASEPVWRP 223

  Rat   279 W 279
            |
  Fly   224 W 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hes1	NP_077336.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		4/10 (40%)
		bHLH-O_HES1_4	33..95	CDD:381465	31/62 (50%)
		Hairy_orange	110..148	CDD:400076	6/40 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..206		12/47 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	255..281		9/25 (36%)
		WRPW motif	276..279		2/2 (100%)
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	29/58 (50%)
		ORANGE	96..136	CDD:128787	6/39 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334580
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840