DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hes1 and E(spl)mbeta-HLH

DIOPT Version :9

Sequence 1:	NP_077336.3	Gene:	Hes1 / 29577	RGDID:	62081	Length:	281	Species:	Rattus norvegicus
Sequence 2:	NP_524505.2	Gene:	E(spl)mbeta-HLH / 43152	FlyBaseID:	FBgn0002733	Length:	195	Species:	Drosophila melanogaster

Alignment Length:	259	Identity:	72/259 - (27%)
Similarity:	110/259 - (42%)	Gaps:	87/259 - (33%)

- Green bases have known domain annotations that are detailed below.

  Rat    33 EHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMT 97
            ::||..||::|::||||||:.|.:||.::::.|.::....::||||||||:||:|::.| |||..
  Fly    12 QYRKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKL-RAQKQ 75

  Rat    98 AALST---------DP--SVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQIN 151
            ..||:         ||  |:...:|||:....|||::.|:...||:.::.|:|:.||.:.:..:.
  Fly    76 LRLSSVTGGVSPSADPKLSIAESFRAGYVHAANEVSKTLAAVPGVSVDLGTQLMSHLGHRLNYLQ 140

  Rat   152 AMTYPGQAHPALQAPPPPPPSGP-GGPQHAPFAPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAK 215
            .:.                ||.| |.|..||       |.......|||.....
  Fly   141 VVV----------------PSLPIGVPLQAP-------VEDQAMVTPPPSECDS----------- 171

  Rat   216 VFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTADSMWRPW 279
                                    ..||...|               :||..|| |:..|||||
  Fly   172 ------------------------LESGACSP---------------APSEASS-TSGPMWRPW 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hes1	NP_077336.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		4/10 (40%)
		bHLH-O_HES1_4	33..95	CDD:381465	28/61 (46%)
		Hairy_orange	110..148	CDD:400076	13/37 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..206		11/48 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..281		10/25 (40%)
		WRPW motif	276..279		2/2 (100%)
E(spl)mbeta-HLH	NP_524505.2	HLH	13..75	CDD:238036	30/62 (48%)
E(spl)mbeta-HLH	NP_524505.2	ORANGE	97..141	CDD:128787	13/43 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334579
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840