DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hes1 and h

DIOPT Version :9

Sequence 1:	NP_077336.3	Gene:	Hes1 / 29577	RGDID:	62081	Length:	281	Species:	Rattus norvegicus
Sequence 2:	NP_001014577.1	Gene:	h / 38995	FlyBaseID:	FBgn0001168	Length:	337	Species:	Drosophila melanogaster

Alignment Length:	320	Identity:	111/320 - (34%)
Similarity:	152/320 - (47%)	Gaps:	91/320 - (28%)

- Green bases have known domain annotations that are detailed below.

  Rat    15 AATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKAD 79
            |..||.:..||.|     ..|:|:|||||||||||||..|::||||||||.|||.:|||||||||
  Fly    17 AVVPAQLKETPLK-----SDRRSNKPIMEKRRRARINNCLNELKTLILDATKKDPARHSKLEKAD 76

  Rat    80 ILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLA 144
            |||.|||||:.|||.|.....:.||.::.|::|||::|:|||:||    .|:....|.|||.||:
  Fly    77 ILEKTVKHLQELQRQQAAMQQAADPKIVNKFKAGFADCVNEVSRF----PGIEPAQRRRLLQHLS 137

  Rat   145 NCMTQINAMTYPGQAHPALQAPPPPPPSGPGGPQHAPFAPPPPLVPIPGGAAPPPGSAPCKLGSQ 209
            ||:..:....:..|.....|:            .||...|.||..|              :..||
  Fly   138 NCINGVKTELHQQQRQQQQQS------------IHAQMLPSPPSSP--------------EQDSQ 176

  Rat   210 AGEAAK-VFG------------GFQVVPA--PDGQFAFLIPN----------------------- 236
            .|.||. :||            |.||:|.  |:|..|.::|.
  Fly   177 QGAAAPYLFGIQQTASGYFLPNGMQVIPTKLPNGSIALVLPQSLPQQQQQQLLQHQQQQQQLAVA 241

  Rat   237 -----GAFAHSGPVI---PVYTSNSGTSVGPNAV----SPSSGSSLT------ADSMWRP 278
                 .|.|...|::   |..|:::|::...::.    :|.|.||.:      |:|.:.|
  Fly   242 AAAAAAAAAQQQPMLVSMPQRTASTGSASSHSSAGYESAPGSSSSCSYAPPSPANSSYEP 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hes1	NP_077336.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		12/28 (43%)
		bHLH-O_HES1_4	33..95	CDD:381465	47/61 (77%)
		Hairy_orange	110..148	CDD:400076	18/37 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..206		8/47 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..281		7/34 (21%)
		WRPW motif	276..279		1/3 (33%)
h	NP_001014577.1	HLH	29..88	CDD:238036	45/63 (71%)
h	NP_001014577.1	ORANGE	106..141	CDD:128787	19/38 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7428
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4240
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1427802at2759
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105205
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3450
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.870