DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GTF2A1 and stnB

DIOPT Version :9

Sequence 1:	NP_056943.1	Gene:	GTF2A1 / 2957	HGNCID:	4646	Length:	376	Species:	Homo sapiens
Sequence 2:	NP_001036318.2	Gene:	stnB / 4379834	FlyBaseID:	FBgn0016975	Length:	1262	Species:	Drosophila melanogaster

Alignment Length:	267	Identity:	63/267 - (23%)
Similarity:	98/267 - (36%)	Gaps:	62/267 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    73 QHQPQQQQHHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIVPDSKLIQHMNASNMSAA 137
            |.|||.|.|.|.|   ...|:..||.|: ||.::...|.|...     ..|:|:..:.|:...:.
  Fly   103 QSQPQLQSHAHPH---PPPPRPLVPPQS-TQDLISTVSSQLDE-----TSSELLGRIPATRSPSP 158

Human   138 ATAATLALP-----AGVTPVQQILTNSGQL-------LQVVRAANGAQYIFQP----------QQ 180
            .:...|..|     :|:..:..:..:||..       ..::....|...:..|          |.
  Fly   159 VSMRDLHSPSPTPDSGLADLLDVSVDSGSSAHTQGIEADLISGVAGGVRLDNPFAVPTAVPNIQA 223

Human   181 SVVLQQQVI--PQMQPGGVQAPVIQQVLAPLPGGISPQTGVIIQPQQILFTGNKTQVIP------ 237
            :|.|....|  |...|....||...   || ||..:||     :|...|...|.....|
  Fly   224 AVPLPATPIKQPPRPPPPRPAPPRP---AP-PGQAAPQ-----RPPPPLAAVNPPPAAPEADDLL 279

Human   238 ----TTV---AAPTPAQAQ--ITATGQQQ--PQAQPAQTQAPLVLQVDGTGDTSSEEDEDEEEDY 291
                ||.   |.|.|.:::  |.:..:|.  |.:|||  ..|.:|. |...:|..|.:..|:|:.
  Fly   280 DMFGTTACKPAKPPPPKSKEDILSLFEQPHVPLSQPA--SKPDLLH-DDLDETIGEGEPPEQEEP 341

Human   292 DDDEEED 298
            |.::..:
  Fly   342 DTEQSNE 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GTF2A1	NP_056943.1	TFIIA	13..376	CDD:397322	63/267 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..107		14/33 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..266		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..329		6/25 (24%)
stnB	NP_001036318.2	Trypan_PARP	377..496	CDD:114603
stnB	NP_001036318.2	AP_MHD_Cterm	897..1219	CDD:299401
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1533
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030