Protein Alignment GTF2A1 and TfIIA-L

DIOPT Version :10

• Sequence 1: NP_056943.1
• Gene: GTF2A1 / 2957
• HGNCID: 4646
• Length: 376
• Species: Homo sapiens
• Sequence 2: NP_476995.1
• Gene: TfIIA-L / 43284
• FlyBaseID: FBgn0011289
• Length: 366
• Species: Drosophila melanogaster
• Alignment Length: 407
• Identity: 144/407 - (35%)
• Similarity: 210/407 - (51%)
• Gaps: 86/407 - (21%)

Human     9 TVPKLYRSVIEDVINDVRDIFLDDGVDEQVLMELKTLWENKLMQSRAV-------DGFHSEEQQL 66
            :|.|:|.:||||||.:|||.|||:|||||||.|:|.:|.|||:.|:||       ||.|
  Fly     7 SVLKVYHAVIEDVITNVRDAFLDEGVDEQVLQEMKQVWRNKLLASKAVELSPDSGDGSH------ 65

Human    67 LLQVQQQHQPQQQQHHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIVPDSKLIQHMNA 131
                                     |...|....::.:.....:::|.|...:.....:..:.:.
  Fly    66 -------------------------PPPIVANNPKSHKAANAKAKKAAAATAVTSHQHIGGNSSM 105

Human   132 SNM----SAAATAATLALPAGVTPV-QQILTNSGQLLQVVRAANGAQYIFQPQQSVVLQQQ---- 187
            |::    |:|..||...:..|:.|: |::.:.:...|....||:    :.|.||......|
  Fly   106 SSLVGLKSSAGMAAGSGIRNGLVPIKQEVNSQNPPPLHPTSAAS----MMQKQQQAASSGQGSIP 166

Human   188 VIPQMQPGGVQAPVIQQVLAPLP-GGISPQTGVI-IQ-PQQILFTGNKTQV-----------IPT 238
            ::..:.|..:. ||  .:..|.| |..|.::.|: || |...|.....||:           :||
  Fly   167 IVATLDPNRIM-PV--NITLPSPAGSASSESRVLTIQVPASALQENQLTQILTAHLISSIMSLPT 228

Human   239 TVAAPTPAQ---AQITATGQQQPQAQPAQTQAPLVLQVDGTGDTSSEEDEDEEED--YDDDEEED 298
            |:|:....|   |.:::...|:..|        ...|:||..| ||:|||.||.|  .|:|:::|
  Fly   229 TLASSVLQQHVNAALSSANHQKTLA--------AAKQLDGALD-SSDEDESEESDDNIDNDDDDD 284

Human   299 KEKDGAEDGQ----VEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMN 359
            .:||..||.:    .|||||||||||:||:..|:|||:||:|||||||.||:|||||:|||||||
  Fly   285 LDKDDDEDAEHEDAAEEEPLNSEDDVTDEDSAEMFDTDNVIVCQYDKITRSRNKWKFYLKDGIMN 349

Human   360 LNGRDYIFSKAIGDAEW 376
            :.|:||:|.|:.|||||
  Fly   350 MRGKDYVFQKSNGDAEW 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GTF2A1	NP_056943.1	TFIIA	13..376	CDD:460829	140/401 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	69..107		2/37 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	247..266		4/21 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..329		32/60 (53%)
TfIIA-L	NP_476995.1	TFIIA	11..366	CDD:460829	140/401 (35%)