Protein Alignment Hes2 and E(spl)m8-HLH

DIOPT Version :10

• Sequence 1: NP_062109.1
• Gene: Hes2 / 29567
• RGDID: 62082
• Length: 157
• Species: Rattus norvegicus
• Sequence 2: NP_524513.1
• Gene: E(spl)m8-HLH / 43161
• FlyBaseID: FBgn0000591
• Length: 179
• Species: Drosophila melanogaster
• Alignment Length: 177
• Identity: 60/177 - (33%)
• Similarity: 90/177 - (50%)
• Gaps: 41/177 - (23%)

  Rat    14 RKSLKPLLEKRRRARINESLSQLKGLVLPLLGAETSRYSKLEKADILEMTVRFLREQ--PASVCS 76
            :|..||:||::||||:|:.|..||.||..|.|.:  ...:::||::||..|.|:|:|  |..|..
  Fly    11 QKVKKPMLERQRRARMNKCLDNLKTLVAELRGDD--GILRMDKAEMLESAVIFMRQQKTPKKVAQ 73

  Rat    77 TEAPGSLDSYLEGYRACLARLARVL---PACSV-LEPAVS---ARLLEHLRQ------------- 121
            .|....|||:..||...:..::||:   |..|| |..:|.   .|:.::|:|
  Fly    74 EEQSLPLDSFKNGYMNAVNEVSRVMASTPGMSVDLGKSVMTHLGRVYKNLQQFHEAQSAADFIQN 138

  Rat   122 ----RTVSGGPPSLTPASA------SAPAPSP-PVPPPSSLGLWRPW 157
                .::...|  |:|||:      .:||||| |:..|    |||||
  Fly   139 SMDCSSMDKAP--LSPASSGYHSDCDSPAPSPQPMQQP----LWRPW 179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hes2	NP_062109.1	bHLH_SF	10..73	CDD:469605	26/60 (43%)
		ORANGE	84..128	CDD:128787	14/67 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	124..157		15/39 (38%)
		WRPW motif	154..157		2/2 (100%)
E(spl)m8-HLH	NP_524513.1	bHLH-O_ESM5_like	12..70	CDD:381486	26/59 (44%)
		ORANGE	81..125	CDD:128787	13/43 (30%)