DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hes2 and dpn

DIOPT Version :9

Sequence 1:	NP_062109.1	Gene:	Hes2 / 29567	RGDID:	62082	Length:	157	Species:	Rattus norvegicus
Sequence 2:	NP_476923.1	Gene:	dpn / 35800	FlyBaseID:	FBgn0010109	Length:	435	Species:	Drosophila melanogaster

Alignment Length:	164	Identity:	60/164 - (36%)
Similarity:	85/164 - (51%)	Gaps:	22/164 - (13%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MRLPRGVGDAAELRKSLKPLLEKRRRARINESLSQLKGLVLPLLGAETSRYSKLEKADILEMTVR 65
            |..|.|: ..|||||:.||::|||||||||..|::||.|:|..:..:.:|::||||||||||||:
  Fly    29 MSNPNGL-SKAELRKTNKPIMEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVK 92

  Rat    66 FL---REQPASVCSTEAPGSLDSYLEGYRACLARLARVLPACSVLEPAVSARLLEHLRQRTVS-- 125
            .|   :.|..::.....|..:..:..|:..|...:.|.:.....::..|..||..||.|...|
  Fly    93 HLQSVQRQQLNMAIQSDPSVVQKFKTGFVECAEEVNRYVSQMDGIDTGVRQRLSAHLNQCANSLE 157

  Rat   126 -------------GGPPSLTPASASAPAPSPPVP 146
                         ||   |.||:|...||:|..|
  Fly   158 QIGSMSNFSNGYRGG---LFPATAVTAAPTPLFP 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hes2	NP_062109.1	HLH	12..69	CDD:238036	34/59 (58%)
		ORANGE	84..128	CDD:128787	11/58 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..157		11/38 (29%)
		WRPW motif	154..157
dpn	NP_476923.1	HLH	39..101	CDD:238036	34/61 (56%)
dpn	NP_476923.1	ORANGE	114..158	CDD:128787	10/43 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1427802at2759
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.880