DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myh7 and Prm

DIOPT Version :9

Sequence 1:	NP_058936.1	Gene:	Myh7 / 29557	RGDID:	62030	Length:	1935	Species:	Rattus norvegicus
Sequence 2:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster

Alignment Length:	836	Identity:	293/836 - (35%)
Similarity:	499/836 - (59%)	Gaps:	6/836 - (0%)

- Green bases have known domain annotations that are detailed below.

  Rat  1091 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGG 1155
            :..||..|.|.|     |..|:.:|..|:::||.||..|.::|:.::|||.::.::|||||||.|
  Fly    25 DVNIEYIQDLSS-----LSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEG 84

  Rat  1156 ATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1220
            ....|.|.|:||:||..|:|:.||:..|:.|.|...|:|||.:.:.:..||::.|.:.|.:.||:
  Fly    85 GAEHQFEANRKRDAELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKD 149

  Rat  1221 KSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTRQRAKLQTENG 1285
            |::|:.|:.::.|.:|...|.|...||....||..::|...|.||..|:|.|::..|::|..||.
  Fly   150 KAKFQTEVYELLSQIESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQENI 214

  Rat  1286 ELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEE 1350
            ||::.:.:.:..:..::..|.....||||.:|:||:|.:.::.|..:|.....:.|.:|.|.|||
  Fly   215 ELTKDVQDLKVQLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEE 279

  Rat  1351 TEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLE 1415
            :||:.:|:|.|.|||::...|:.|:.::...|.||:||.::|...|:.:.||.:|::..|.::||
  Fly   280 SEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLE 344

  Rat  1416 KTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILVEWKQKYEESQSELESSQKEARSLSTE 1480
            |.|.||.:|:|.|::|:|:||.:...|.|.....:|..||.|.:.:|:....|:||::.::...:
  Fly   345 KMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHAD 409

  Rat  1481 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSTGKSIHELEKIRKQLEAEKLELQSALE 1545
            |.:..:..::..::.....||||.|.:::.:....:....:.:||||...::||.|:.||.:|.:
  Fly   410 LVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERDELTAAYK 474

  Rat  1546 EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTS-LDAETRSRN 1609
            ||||..:.||.:..|...:|||.:.:.||:|||||||:|..::.....::.|... ::||||.:.
  Fly   475 EAEAGRKAEEQRGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAETRLKT 539

  Rat  1610 EALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
            |..|:|||::..:.|:|:.|..||:...:.||.:|.....|.:.|...:|..|......:..|:.
  Fly   540 EVTRIKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQATLDQYAVA 604

  Rat  1675 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQT 1739
            :||...|..||||:|:.::...|:::..|.:..|.:.|:..|.:.|.||::.|.|::.:||.:.:
  Fly   605 QRRLAGLNGELEEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVAS 669

  Rat  1740 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKNNMEQTIKDLQHRLDEAEQIA 1804
            :.||..:|.|.::|:.:|...:...:.|::.:||:....||.:|.::|..:|:|..||:|.|..|
  Fly   670 DYEEVSKELRISDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRLEEVELNA 734

  Rat  1805 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVD 1869
            :.|.|:.:.|||||:|:||.|||.|::|:||::|.:||.||.:||:..|.|||:|||:.|||.:|
  Fly   735 VAGSKRIISKLEARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILLQDALD 799

  Rat  1870 KLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1925
            |...|:..|:||..|.|..:....::.|:.|.||:.||:|||.|||.:|.:|||.|
  Fly   800 KSTAKINIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHR 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myh7	NP_058936.1	Myosin_N	35..72	CDD:280832
		Myosin_head	87..766	CDD:278492
		MYSc_class_II	99..766	CDD:276951
		Actin-binding	655..677
		Actin-binding	757..771
		Myosin_tail_1	846..1923	CDD:279860	290/832 (35%)
		MM_CoA_mutase	<1132..1293	CDD:294532	60/160 (38%)
		BAR	1232..1424	CDD:299863	65/191 (34%)
		TMPIT	1740..>1830	CDD:285135	33/89 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1915..1935		6/11 (55%)
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	287/823 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810