DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myh7 and didum

DIOPT Version :9

Sequence 1:NP_058936.1 Gene:Myh7 / 29557 RGDID:62030 Length:1935 Species:Rattus norvegicus
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:1950 Identity:506/1950 - (25%)
Similarity:860/1950 - (44%) Gaps:476/1950 - (24%)


- Green bases have known domain annotations that are detailed below.


  Rat    19 SEKERLEAQTRPFDLKKDVFVPDDKEEFVKAKIVS--REG-GKVTAETENGKTVTVK-----EDQ 75
            |.:|.|.||      ...::||.....:..|.:..  |:| |.:...|::||...||     .|.
  Fly     2 SSEEMLYAQ------GAKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDL 60

  Rat    76 VMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKERYAS-WMIYTYSGLFCVTVNPYKWLPVYNAQVV 139
            ...:||.......|:..|::||||.||:||:.|:.. .:||||.|:..|.:|||..:|:|...::
  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125

  Rat   140 AAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDR 204
            .||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::||   ||:|..
  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYF---AAVGGS 187

  Rat   205 SKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHF-GATGK--LASADIETY 266
            ..:.|      :|.:::.::|.:||||||||.|||||||||||.::.| ...|.  |..|.:.||
  Fly   188 ESETQ------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTY 246

  Rat   267 LLEKSRVIFQLKAERDYHIFYQILS--NKKPELLDMLLITNNPYDYAFFSQ-GETTVASIDDSEE 328
            |||||||::|.:.||:||||||:.:  :|.||     |:.::...:.|.:. |...:..:.|:|:
  Fly   247 LLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDAEQ 306

  Rat   329 HMATDSAFDVLGFTPEEKNSIYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADK---------- 383
            ...|..|..||||:.::...|.|:...|:|.||::..:|..|      |:||.|.          
  Fly   307 FNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNE------GSEEEDSDSCDIFHNDI 365

  Rat   384 ----SAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVAYAIGALAKSVYEKMFNWMVTRIN 444
                :|.|:.:::.||.:.|...:::..||||....:::....|..||||.:|.|:|.::|..:|
  Fly   366 HLQITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLN 430

  Rat   445 ATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWT 509
            .:|.....:..|||||||.|||.|:.|||||.|||:.||||||.||.|:|.||||||.||||.||
  Fly   431 KSLNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWT 495

  Rat   510 FIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSN---NFQKPRNIKG 571
            .||| .|.|.||||||..:|::.:|:|||..||.:|.::..||    :||.|   :|:|||    
  Fly   496 MIDF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPR---- 551

  Rat   572 KQEAHFSLIHYAGTVDYNILGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPVDKGK- 635
            .....|.:.|::.||:|::.|:|:||:|.:::.:..:..:|::.|...:..........||..| 
  Fly   552 FGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKS 616

  Rat   636 -----------GKAKKGSSF-----------QTVSALHRENLNKLMTNLRSTHPHFVRCIIPNET 678
                       |:.::|:..           :||.:..:|:|..|::.|.:|.||:||||.||:.
  Fly   617 STLGGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDD 681

  Rat   679 KSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRIL--------NPAAIPEGQF 735
            |.....:...::.|||..||||.:||...|||:|.||.||..||::|        |         
  Fly   682 KVAFKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--------- 737

  Rat   736 IDSRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDE--------------------- 779
             |.:.....::.....|.::|:||:|::||:||.:..||::|..                     
  Fly   738 -DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQ 801

  Rat   780 --RLSRIITRIQAQSRGVLSRMEFKKLLERRDSLLIIQWNIRAFMGVKNWPWMKLYFKIKPLLKS 842
              |:.::|..||..:||.|:|...:|:.|.|..|::.::       .:.|...:.|.:::..:..
  Fly   802 FLRIQKVINGIQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISG 859

  Rat   843 AETEKEMANMKEEFGRVKD--------------------------------ALEKSEARRK---- 871
            .:|.......:.:|..::|                                |:.:..||||    
  Fly   860 IQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRM 924

  Rat   872 ---------------ELEEKMVSL-----------------------LQEKNDLQLQVQAEQDNL 898
                           .||.|::|:                       |:.|.:|:..::||..|:
  Fly   925 KAEAKTISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFKNV 989

  Rat   899 ADAEERCDQLIK--NKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTL 961
            ..|.:..|:||:  || ||||:..|..:.||:......|..::|:....|..||:|.||::    
  Fly   990 KAACQDKDKLIEALNK-QLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEI---- 1049

  Rat   962 AKVEKEKHATENKVKNLTEEMAGLDEIIVKLTKEKKALQEAHQQALDDLQAEE-------DKVNT 1019
              ::..|:|..|: :|..:.|  |.||      :.:.|.||:|:|:.|.:..|       ::::.
  Fly  1050 --IDMAKNAEVNQ-RNQEDRM--LAEI------DNRELNEAYQRAIKDKEVIENENFMLKEELSR 1103

  Rat  1020 LTKAKVKLEQQVDDLEGSLDQDKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKD 1084
            ||.....|..:......|.::|     |:..|..|          :.:|:......|.:.....|
  Fly  1104 LTAGSFSLHARKASNASSQNED-----DVGYASAK----------NTLDINRPPDLLSKNYSYND 1153

  Rat  1085 FELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISER 1149
                            .:.|..||:.:      ||||.:..:..:.:..||.|  ..:..|.|.|
  Fly  1154 ----------------STSLVVKLRSI------LEEEKQKHKVLQEQYIKLSS--RHKPTEDSFR 1194

  Rat  1150 LEEAGGATSVQIEMNKKREAEFQKMRR------DLEEATLQHEATAAALRKKHADSV---AELGE 1205
            :.|      :::| |:|..:|:.::|.      ::.|...||.|....:|::..:.:   |.|.:
  Fly  1195 VSE------LEVE-NEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLKAVLLQ 1252

  Rat  1206 QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQM----NEHRSKAEET 1266
            |..:::.:      |....::..:||...||.....|.    :.|.||.::    .||.||..| 
  Fly  1253 QSQSMRSL------EPESLQMRGNDVNELMEAFHSQKL----INRQLESELKAITEEHNSKLVE- 1306

  Rat  1267 QRSVNDLTRQRAKLQTENGELSR----QLDE-KEALISQLTRGKLTYTQQLEDLKRQ---LEEEV 1323
                  :|::..:|..|..||.:    .:|| :::.:..|.:......::|:....|   ::||:
  Fly  1307 ------MTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEEL 1365

  Rat  1324 KAKNALAHALQSARHDCDLLREQYEEE------TEAKAELQRVLSKANSEVAQWRTKYETDAIQR 1382
            |..||   .|::.|.|...|..:.|||      ....|::...::|..|:..|...|:.:..:.:
  Fly  1366 KLANA---KLKAYRQDGGQLEHKIEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDK 1427

  Rat  1383 TEELEEAKKKLAQR----------------------LQDAEEAVEAVNAK----CSSLEKTKHRL 1421
            .  |:.....|..|                      |.:|::.|..:.:|    ...:.:|.|.:
  Fly  1428 I--LQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPI 1490

  Rat  1422 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILVEWKQKYEESQSELESSQK-------EARSLST 1479
            :|.:..|:..:...|     |.|:..:.|        :|.:..:|.::.|:       |.|.:..
  Fly  1491 ENRVIWLVNSITLLN-----LMKQYGDVD--------EYVKFNTEKQNQQQLKNFNLFEYRRVIL 1542

  Rat  1480 ELFKLKNAYEESLEHLETFK--------RENKNLQ--EEISDLTEQLGSTGKS------------ 1522
            :|  :.|.|:..:..::...        ..|..:|  .:...:..:..|.|.|            
  Fly  1543 DL--IVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWK 1605

  Rat  1523 --IHELEKIRKQLE--------AEKLELQSALEEAEASLE----------HEEGKILR------- 1560
              |.:||...||.:        ||::..|........:|.          .|.|.|:|       
  Fly  1606 QLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIE 1670

  Rat  1561 --------------AQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEA 1611
                          |....||:...::.:.:|:|          ::.:..|.|||     |..:.
  Fly  1671 DWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQD----------VQTICDLCTSL-----STAQV 1720

  Rat  1612 LRVKK-----------------KMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD 1659
            |:|.|                 |:...||..::|.|:::....: ||.::..:.:.:.:.|:|:|
  Fly  1721 LKVMKSYKLDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTID-QKFIQPFKVVFRYSDIKLED 1784

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh7NP_058936.1 Myosin_N 35..72 CDD:280832 9/39 (23%)
Myosin_head 87..766 CDD:278492 270/733 (37%)
MYSc_class_II 99..766 CDD:276951 265/721 (37%)
Actin-binding 655..677 11/21 (52%)
Actin-binding 757..771 7/13 (54%)
Myosin_tail_1 846..1923 CDD:279860 195/1036 (19%)
MM_CoA_mutase <1132..1293 CDD:294532 39/177 (22%)
BAR 1232..1424 CDD:299863 47/235 (20%)
TMPIT 1740..>1830 CDD:285135
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1915..1935
didumNP_724569.1 MYSc 65..778 CDD:214580 277/751 (37%)
MYSc_Myo5 84..767 CDD:276831 265/721 (37%)
IQ 900..922 CDD:197470 5/21 (24%)
GBP_C <971..1086 CDD:303769 40/130 (31%)
coiled coil 1049..1068 CDD:293879 5/27 (19%)
coiled coil 1077..1086 CDD:293879 4/8 (50%)
JAKMIP_CC3 <1190..1299 CDD:292653 26/125 (21%)
Myo5_CBD 1424..1792 CDD:271254 63/393 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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