DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myh6 and ck

DIOPT Version :9

Sequence 1:NP_058935.2 Gene:Myh6 / 29556 RGDID:62029 Length:1939 Species:Rattus norvegicus
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2113 Identity:547/2113 - (25%)
Similarity:879/2113 - (41%) Gaps:462/2113 - (21%)


- Green bases have known domain annotations that are detailed below.


  Rat    26 AQTRPFDIRTECFVPDDKEEYVKAKIVSREGGKVTAETENGKTV-TVKEDQVMQQNPPKFDKIED 89
            |..|.||:.            :.|::||.||.::....::|..| ...|.::...:......:||
  Fly    15 ASGREFDVA------------IGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVED 67

  Rat    90 MAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHI 154
            |..|..|||..:|.||..||...:||||:|...|.||||:.||:|..:.:..|:.:|..|.||||
  Fly    68 MISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHI 132

  Rat   155 FSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRSKKDNPNANKGTLED 219
            |:|.||||.:|...|::|.|:|:||||||||.:||.::||.|:|:  |..|          .:|.
  Fly   133 FAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS--GKHS----------WIEQ 185

  Rat   220 QIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNY 284
            ||::|||.|||||||||:||||||||||:|.|||.|.|.:..|.||.|||||||::.|..:||||
  Fly   186 QILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNY 250

  Rat   285 HIFYQI---LSNKKPELLDMLLVTNNPYDYAFVSQG-EVSVASIDDSEELLATDSAFDVLGFTAE 345
            |:||.|   ||..:...||:.:..    ||.:::.| .::....||:.|.....||..||.|:.:
  Fly   251 HVFYCILAGLSADEKSRLDLGMAA----DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQ 311

  Rat   346 EKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTE-----DADKSAYLMGLNSADLLKGLCHPRV 405
            |...:.||..|::|.||:|:|....:..   |.||     :.::.|.|:||....|:..|....:
  Fly   312 EIWEIIKLLAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTL 373

  Rat   406 KVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRIN-ATLETKQPRQYFIGVLDIAGFEIF 469
            ....|.|....|..|......|..|.:|.:||..:|.:|| |..:.:...:..||||||.|||.|
  Fly   374 FAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENF 438

  Rat   470 DFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIE-KPMGIMS 533
            |.|||||.|||:.||.|||||..|:|.||||||..|.|.|:.|:| :|.|..:|||. |.:.||:
  Fly   439 DQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMA 502

  Rat   534 ILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHFSLVHYAGTVDYNILGWLEKN 598
            :::||..|||.||.|..|||:..| |...|:.||   |......|.|.|:||.|.|:..|:|:||
  Fly   503 LIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLDKN 563

  Rat   599 KDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSGKGKGGKKKGSSFQTVSALHRENLNKLMTN 663
            :|..:..::.|..:|:.|.:..:|:.       |...|...:|:   ..|:|...|::|:.||..
  Fly   564 RDTFSPDLLHLVSQSTNKFLRQIFAQ-------DIEMGAETRKR---TPTLSTQFRKSLDALMKT 618

  Rat   664 LRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILN 728
            |.:..|.|:|||.|||.|.|.:.|..|...|||.:|::|.|||.|.|:|.|..:.:|.:|||.|.
  Fly   619 LSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI 683

  Rat   729 PAAIPEGQFIDSRKGAEKL----LGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITR 789
            | .:|.....|.:....::    ||..|     |:.||||||.|......||:.||..|:|.|..
  Fly   684 P-GVPPAHRTDCQAATSRICAVVLGKSD-----YQLGHTKVFLKDAHDLFLEQERDRVLTRKILI 742

  Rat   790 IQAQARGQLMRIEFKKMVERRDALLVIQWNIRAFMGVKNWPWMKL-YFKIKPLLKSAETEKEMAN 853
            :|...||.:.|..|.::   |.|.:.:|...:.:...|.:..|:: |.:::.|::|........:
  Fly   743 LQRSIRGWVYRRRFLRL---RAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRH 804

  Rat   854 MKEEFGRVKDALEKSEAR----RKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNK 914
            ::   |.:...  ::.||    |:|...||.::::.::.::..:...:              ..|
  Fly   805 LR---GHIVGL--QAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRR--------------YRK 850

  Rat   915 IQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 979
            ::||.  |:..|.|:            .||||::  ||..            ...|||.|...::
  Fly   851 LRLEH--KQFAEVLQ------------LRKLEEQ--ELLH------------RGNKHAREIAEQH 887

  Rat   980 LTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLIKSKVKLEQQVDD---LEGSLE 1041
            ..:.:..|         |::.:||    .|::.:..|..:|.:..:..|.|:.|||   :|...:
  Fly   888 YRDRLHEL---------ERREIQE----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFD 939

  Rat  1042 ---------------QEKKVRMDLERAKRKLEGDLKLTQESI---MDLENDKLQLEEKLKKKEFD 1088
                           :|..|..||..|:       .:.|:.|   :.:..|:..|.| .|.::|.
  Fly   940 FLPDSSSDAPTPHGGRETSVFNDLPHAQ-------NVNQDDIIAPIHISEDEEDLSE-FKFQKFA 996

  Rat  1089 ISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLTRELEEISERLE 1153
            .:.....:..:.|     :|.||.....:....::|.|: .....:.:...|:........:|::
  Fly   997 ATYFQGNVNHQYA-----KKALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMD 1055

  Rat  1154 EAGGATSVQIEMNKK--REAEFQK---MRRD------LEEATLQHEATAAALRKKHADSVAELGE 1207
            .....:.|...:.:.  |..|||:   |..|      .:..:::|:..:..|::|:     :|||
  Fly  1056 TTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-----KLGE 1115

  Rat  1208 QIDNLQRVKQKLEKEKSEFKLELDD-VTSNMEQ--------IIKAKANLE---KVSRTL------ 1254
            .:   :|..|..|.....::..|.. .|||:|:        |::|:...|   ::.:.|      
  Fly  1116 DV---RRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLK 1177

  Rat  1255 --------------------EDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEAL 1299
                                |...|..|..:.|.......:..:|.|....||   .:.:....|
  Fly  1178 SSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNG---TRNQPPSWL 1239

  Rat  1300 ISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCD------LLREQY--------- 1349
            ..|.|:.|......:..:      :|..|..||.:..:||..|:      .|::|:         
  Fly  1240 ELQATKSKKPIMLPITFM------DGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALF 1298

  Rat  1350 ----------EEEMEAKAELQRVLSK--ANSEVAQWRTKYETDAIQRTEE-----------LEEA 1391
                      :..|:|.::.::...:  |....|.||..:..:......|           .::.
  Fly  1299 DKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQV 1363

  Rat  1392 KK--KLAQRLQDAEEAVEAVNAK--------CSSLEKTKHRLQNEIEDLM---VDVERSNAAAAA 1443
            .:  |..:...|.||.:..:.|:        ..|:|:....|.|.|.|..   ||......||..
  Fly  1364 VRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALV 1428

  Rat  1444 LDKKQRNF---DK------------------------------------------ILAEWKQKY- 1462
            |...::::   ||                                          |...|...| 
  Fly  1429 LQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYV 1493

  Rat  1463 --EESQSELESSQKEARSLS--------TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1517
              ::.|..||.|..|..::|        |:.|.|.....|..    ||:..|   .|:|.||.  
  Fly  1494 VDDQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEF----TFQSPN---AEDIRDLV-- 1549

  Rat  1518 LGEGGKNVHELEKIRKQLE-VEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEK 1581
                   |:.|:.::|:.: |..|:...|..:..:.|...:|.::..:                 
  Fly  1550 -------VYFLDGLKKRSKYVIALQDYRAPSDGTSFLSFFKGDLIILE----------------- 1590

  Rat  1582 DEEMEQAKRNH---LRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQK 1643
            ||...::..|:   :...|..|...|....:......:.|..:..|....|:.:...|..|.|..
  Fly  1591 DESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMASN 1655

  Rat  1644 HLKNAQAHLKDTQLQLDDAVRANDDLKENIAIVERRNTLLQAELEELRAVVEQTERSRKLAEQEL 1708
                            ..||...|          |.:||::..|:..|...::|      ..:.|
  Fly  1656 ----------------GGAVEPRD----------RPHTLMEYALDHFRLPPKRT------MSKTL 1688

  Rat  1709 IETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKK 1773
            ..:|:|.:.|...:...|....     |.:||::.|.|.:.|              ...|..||.
  Fly  1689 TLSSKRSEELWRYSRDPIKAPL-----LRKLQSKEEFAEEAC--------------FAFAAILKY 1734

  Rat  1774 EQDTSAHLERMKKNMEQTIKD--LQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNA 1836
            ..|..:...||...:...|.|  |:|.:...|...      ||.|     :..:|.....::|..
  Fly  1735 MGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYC------QLMK-----QLTDNRNRMSEERGW 1788

  Rat  1837 ESV---KGM-RKSERRIKEL-----TYQTEEDKKNLVRLQDLVDKLQLKVKAYKRQAEEAEEQAN 1892
            |.:   .|: ..|:..:|||     |.:....:.::.|||..:...|.|...::.:. ||.:...
  Fly  1789 ELMWLATGLFACSQGLLKELLLFLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVEV-EAIQHKT 1852

  Rat  1893 TNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1925
            |.:  |.||... |:.:|..::..|    .|||
  Fly  1853 TQI--FHKVYFP-DDTDEAFEVDSS----TRAK 1878

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh6NP_058935.2 Myosin_N 34..72 CDD:397036 7/38 (18%)
MYSc_class_II 99..768 CDD:276951 280/683 (41%)
Actin-binding 657..679 10/21 (48%)
Actin-binding 759..773 7/13 (54%)
Calmodulin-binding. /evidence=ECO:0000250 790..807 5/16 (31%)
Calmodulin-binding. /evidence=ECO:0000250 816..833 2/16 (13%)
Myosin_tail_1 848..1925 CDD:396244 225/1272 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1908..1939 5/18 (28%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 290/708 (41%)
MYSc_Myo7 77..721 CDD:276832 280/683 (41%)
MyTH4 <1138..1245 CDD:214535 18/109 (17%)
B41 1251..1467 CDD:214604 34/221 (15%)
FERM_B-lobe 1355..1439 CDD:271216 16/83 (19%)
FERM_C1_MyoVII 1461..1559 CDD:270019 22/113 (19%)
SH3 1560..1624 CDD:302595 11/80 (14%)
MyTH4 1701..1849 CDD:214535 37/178 (21%)
B41 1856..2068 CDD:214604 9/28 (32%)
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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