DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdha1 and Pdha

DIOPT Version :9

Sequence 1:	NP_001004072.2	Gene:	Pdha1 / 29554	RGDID:	3286	Length:	390	Species:	Rattus norvegicus
Sequence 2:	NP_726945.1	Gene:	Pdha / 31406	FlyBaseID:	FBgn0028325	Length:	443	Species:	Drosophila melanogaster

Alignment Length:	367	Identity:	214/367 - (58%)
Similarity:	269/367 - (73%)	Gaps:	2/367 - (0%)

- Green bases have known domain annotations that are detailed below.

  Rat    14 GAAQKPASRVLVASRNFANDATFEIKK-CDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELK 77
            |..|..|...:..:.|:|.:||.::.: ..||||:|||.....||::..||||..|||:||:|..
  Fly    61 GLFQNAAQAGVSKTNNYATEATVQVNRPFKLHRLDEGPATEVKLTKDQALKYYTQMQTIRRLETA 125

  Rat    78 ADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLPVRAILAELTGRR 142
            |..|||:|||||||||..|||||.||::|.:...|::|:|||.||:|:..|:....:||||||.:
  Fly   126 AGNLYKEKIIRGFCHLYSGQEACAVGMKAAMRDVDNIISAYRVHGWTYLMGVSPSGVLAELTGVQ 190

  Rat   143 GGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEA 207
            ||||:||||||||||.||||||||||||||||||:.|||||.|...:||.|||||||||||:|||
  Fly   191 GGCARGKGGSMHMYAPNFYGGNGIVGAQVPLGAGVGLACKYKGNGGMCLALYGDGAANQGQVFEA 255

  Rat   208 YNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATKFAAAY 272
            ||||.|||||.||:||||.||||||.|||:.:||||.|||.:||:.|||||:|.||.||:||..|
  Fly   256 YNMAYLWKLPVIFVCENNNYGMGTSSERASCNTDYYTRGDALPGIWVDGMDVLAVRSATEFAINY 320

  Rat   273 CRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE 337
            ..: .||::||..||||.||||||||.||||||||||||.|.|||...|:..:...|.:.:|:|.
  Fly   321 VNT-HGPLVMETNTYRYSGHSMSDPGTSYRTREEIQEVRQKRDPITSFKELCIELGLITTDEVKA 384

  Rat   338 IDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRG 379
            ||::||||:::|..||.:|.|..:..|...:||::...::||
  Fly   385 IDLKVRKEVDEATAFAKSDAELGVSHLWTDVYSNNLEPKLRG 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdha1	NP_001004072.2	PDH_E1_alph_y	58..370	CDD:274473	194/311 (62%)
Pdha	NP_726945.1	TPP_enzymes	78..426	CDD:294952	208/348 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337616
Domainoid	1	1.000	401	1.000	Domainoid score	I712
eggNOG	1	0.900	-	-		E1_COG0462
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1593
OMA	1	1.010	-	-		QHG54057
OrthoDB	1	1.010	-	-		D318981at33208
OrthoFinder	1	1.000	-	-		FOG0001471
OrthoInspector	1	1.000	-	-		otm45497
orthoMCL	1	0.900	-	-		OOG6_100754
Panther	1	1.100	-	-	O	PTHR11516
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X926
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770