DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdx1 and ftz

DIOPT Version :9

Sequence 1:	NP_074043.4	Gene:	Pdx1 / 29535	RGDID:	62387	Length:	283	Species:	Rattus norvegicus
Sequence 2:	NP_477498.1	Gene:	ftz / 40834	FlyBaseID:	FBgn0001077	Length:	410	Species:	Drosophila melanogaster

Alignment Length:	200	Identity:	68/200 - (34%)
Similarity:	93/200 - (46%)	Gaps:	50/200 - (25%)

- Green bases have known domain annotations that are detailed below.

  Rat    61 SPPDISPYEVPPLADDPAGAHLHHHLPAQLGLAHPPPGPFPNGTETGGLEEPSR-VHLP-----F 119
            :||..:|..:|||.                |::.||..|....:.....|...| |..|     |
  Fly   190 TPPPTTPTSLPPLE----------------GISTPPQSPGEKSSSAVSQEINHRIVTAPNGAGDF 238

  Rat   120 PWMKSTKAHAWKSQWAGGAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLN 184
            .|     :|..::      .|::.:::||||..|||.|.|||||||.||:||:|.||:::|..|:
  Fly   239 NW-----SHIEET------LASDCKDSKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALS 292

  Rat   185 LTERHIKIWFQNRRMKWKKEEDKKRSSGTTSGGGGGEEPEQDCAVTSGEELLALPPPPPPGGAVP 249
            |:||.|||||||||||.||:.....|            ||. |    |....|:.||........
  Fly   293 LSERQIKIWFQNRRMKSKKDRTLDSS------------PEH-C----GAGYTAMLPPLEATSTAT 340

  Rat   250 SGVPA 254
            :|.|:
  Fly   341 TGAPS 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdx1	NP_074043.4	Transactivation domain	13..73		4/11 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..81		6/19 (32%)
		Antp-type hexapeptide	118..123		3/9 (33%)
		Homeobox	149..203	CDD:395001	36/53 (68%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..283		12/53 (23%)
ftz	NP_477498.1	FTZ	1..248	CDD:281812	17/84 (20%)
ftz	NP_477498.1	Homeobox	257..310	CDD:278475	36/52 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810